Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
300 participants
OBSERVATIONAL
2018-09-12
2021-03-05
Brief Summary
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The investigators hypothesize that patients being administered higher midazolam doses will refer more pain.
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Detailed Description
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The investigators intend to clarify the relation between anxiety, preoperative midazolam and postoperative pain.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Midazolam injection
The dose of preoperative midazolam is the predictor variable and will be registered as a continuous variable in a single cohort.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* alcoholism
* illiteracy or poor understanding of the Portuguese language
* history of chronic pain under opioids
* recurrent surgery
18 Years
ALL
No
Sponsors
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Universidade do Porto
OTHER
Responsible Party
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Caroline Dahlem
Principal Investigator
Principal Investigators
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Caroline Dahlem, MD
Role: PRINCIPAL_INVESTIGATOR
UPorto /CINTESIS
Locations
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Centro Hospitalar Baixo Vouga, EPE
Aveiro, , Portugal
Centro Hospitalar Universitário do Algarve
Faro, , Portugal
Centro Hospitalar Entre Douro e Vouga, EPE
Santa Maria da Feira, , Portugal
Centro Hospitalar Vila Nova de Gaia / Espinho, EPE
Vila Nova de Gaia, , Portugal
Countries
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References
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Mantegazza P, Parenti M, Tammiso R, Vita P, Zambotti F, Zonta N. Modification of the antinociceptive effect of morphine by centrally administered diazepam and midazolam. Br J Pharmacol. 1982 Apr;75(4):569-72. doi: 10.1111/j.1476-5381.1982.tb09175.x.
Okulicz-Kozaryn I, Kaminska E, Luczak J, Szczawinska K, Kotlinska-Lemieszek A, Baczyk E, Mikolajczak P. The effects of midazolam and morphine on analgesic and sedative activity of ketamine in rats. J Basic Clin Physiol Pharmacol. 2000;11(2):109-25. doi: 10.1515/jbcpp.2000.11.2.109.
Tatsuo MA, Salgado JV, Yokoro CM, Duarte ID, Francischi JN. Midazolam-induced hyperalgesia in rats: modulation via GABA(A) receptors at supraspinal level. Eur J Pharmacol. 1999 Apr 1;370(1):9-15. doi: 10.1016/s0014-2999(99)00096-5.
Frolich MA, Zhang K, Ness TJ. Effect of sedation on pain perception. Anesthesiology. 2013 Mar;118(3):611-21. doi: 10.1097/ALN.0b013e318281592d.
Kain ZN, Sevarino F, Pincus S, Alexander GM, Wang SM, Ayoub C, Kosarussavadi B. Attenuation of the preoperative stress response with midazolam: effects on postoperative outcomes. Anesthesiology. 2000 Jul;93(1):141-7. doi: 10.1097/00000542-200007000-00024.
Coulthard P, Rood JP. An investigation of the effect of midazolam on the pain experience. Br J Oral Maxillofac Surg. 1992 Aug;30(4):248-51. doi: 10.1016/0266-4356(92)90268-n.
Day MA, Rich MA, Thorn BE, Berbaum ML, Mangieri EA. A placebo-controlled trial of midazolam as an adjunct to morphine patient-controlled analgesia after spinal surgery. J Clin Anesth. 2014 Jun;26(4):300-8. doi: 10.1016/j.jclinane.2013.12.011. Epub 2014 Jun 2.
Hasani A, Maloku H, Sallahu F, Gashi V, Ozgen SU. Preemptive analgesia with midazolam and diclofenac for hernia repair pain. Hernia. 2011 Jun;15(3):267-72. doi: 10.1007/s10029-010-0772-y. Epub 2010 Dec 28.
Ong CK, Seymour RA, Tan JM. Sedation with midazolam leads to reduced pain after dental surgery. Anesth Analg. 2004 May;98(5):1289-93, table of contents. doi: 10.1213/01.ane.0000111107.18755.cc.
Other Identifiers
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Midazolam OBS
Identifier Type: -
Identifier Source: org_study_id
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