Evaluation of Damaging Factors to Endothelial Glycocalyx During Heart Surgery Pilot Study
NCT ID: NCT03491163
Last Updated: 2018-08-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
150 participants
OBSERVATIONAL
2018-03-29
2020-07-01
Brief Summary
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Detailed Description
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1. To evaluate changes of syndecan-1 concentration during surgery and postoperative period.
2. Determine the effect of aortic clamping and on-pump duration on endothelial glycocalyx damage.
3. Assess the risk of early postoperative complications and syndecan-1 plasma concentrations.
4. To evaluate the correlation of inflammatory status with glycocalyx damage.
5. To evaluate glycocalyx damage to patients with diabetes vs non-diabetes.
Methods:
Patients undergoing cardiopulmonary bypass surgery are being treated at the Heart, Chest and Vascular Surgery Clinic of the Lithuanian University of Health Sciences Hospital in Kaunas Clinics. After receiving patients written consent a syndecan-1 concentration test will be performed upon arrival at the operating room, before cardiopulmonary bypass (CPB), after CPB, upon arrival in the ICU and after 24 hours.
All needed data for evaluating patients outcome will be taken from medical documentation during patients stay in hospital.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Patients
Syndecan-1 concentration evaluation
Syndecan-1 concentration evaluation
Blood sample will be taken and analysed using ELISA method.
Interventions
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Syndecan-1 concentration evaluation
Blood sample will be taken and analysed using ELISA method.
Eligibility Criteria
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Inclusion Criteria
* Normal heart function at the time of operation.
* Patients without infections.
* Patients who signed study informed consent form
Exclusion Criteria
* Renal or hepatic dysfunction.
* Off-pump heart operation.
18 Years
ALL
No
Sponsors
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Tadas Cesnaitis
OTHER
Responsible Party
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Tadas Cesnaitis
PhD student
Principal Investigators
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Edmundas Sirvinskas, Prof
Role: PRINCIPAL_INVESTIGATOR
Professor at Lithuanian University of Health Sciences
Locations
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Lithuanian University of Health Sciences
Kaunas, , Lithuania
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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ENDOTEL SYNDECAN-1
Identifier Type: -
Identifier Source: org_study_id
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