The Role of the Muscle-nervous System Interface in Cancer Cachexia

NCT ID: NCT03477721

Last Updated: 2018-03-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-03-16

Study Completion Date

2018-04-30

Brief Summary

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Sarcopenia is an important component of cachexia associated with cancer, and their high incidence in cancer patients emphasizes the need for a better understanding of its mechanisms, which can result in better therapeutic interventions to reverse this situation and improve the prognosis. Our hypothesis is that the plasma concentration of IL-6 and c-terminal agrin is directly correlated with the loss of muscle mass and development of cachexia.

Detailed Description

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The agrin is a protein that acts on neuromuscular junctions (NMJs) promoting stabilization of same, which results in the maintenance and growth of muscle fibers, but the cleavage of agrin, a process by which is formed the agrin fragment C-terminus (CAF), has been linked to the development of sarcopenia, because its presence is directly linked to the reduction in the number of muscle fibers, increasing the heterogeneity of fiber size, presence of Central cores and increasing the proportion of type I fibers and consequently a greater degradation of lean body mass. Studies in mice show that the greatest cleavage of agrin carries on development of sarcopenia and human studies report that individuals with higher serum levels of sarcopenia CAF compared to individuals without sarcopenia.

Therefore, aiming at the complexity of cancer associated with the cachexia and the great importance of the maintenance of lean body mass to a better prognosis in disease, is of fundamental importance to elucidate the role of CAF and the factors associated with sarcopenia, the possible use of these proteins for diagnosis and the contribution that this clarification could bring in clinical therapy.

Conditions

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Cachexia; Cancer; Sarcopenia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Group with cancer cachexia (CTB)

For diagnosis of cachexia it will be used the following criteria (Evans et al., 2008)

No interventions assigned to this group

Group without cancer cachexia (TB)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* cancer diagnosis

Exclusion Criteria

* continuously use of anti-inflammatory medications;
* present renal and/or liver failure,
* AIDS,
* inflammatory bowel disease or chronic inflammatory processes not related to cachexia.
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Roma La Sapienza

OTHER

Sponsor Role lead

Responsible Party

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Alessandro Laviano

Alessandro Laviano, MD associate professor of Internal Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Alessandro Laviano, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Clinical Medicine, Sapienza University of Rome, Italy

Locations

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Department of Clinical Medicine, Sapienza University of Rome

Rome, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Laviano Alessandro

Role: CONTACT

+390649973902

Facility Contacts

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Alessandro Laviano, MD

Role: primary

+390649973902

References

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Other Identifiers

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NUMANCAN

Identifier Type: -

Identifier Source: org_study_id

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