A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression

NCT ID: NCT03460756

Last Updated: 2023-08-18

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

84 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-12-28

Study Completion Date

2019-07-05

Brief Summary

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A clinical study to evaluate safety, tolerability and efficacy of oral administration of ganaxolone in women with postpartum depression

Detailed Description

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Conditions

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Depressive Disorder Depression Depression, Postpartum Behavioral Symptoms Mood Disorders Mental Disorder Pregnancy Complications Postpartum Blues PPD Postpartum Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Ganaxolone

Oral

Group Type EXPERIMENTAL

Ganaxolone

Intervention Type DRUG

Oral

Placebo

Oral

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Oral

Interventions

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Ganaxolone

Oral

Intervention Type DRUG

Placebo

Oral

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Experiencing a major depressive episode, which started between the start of the third trimester and 4 weeks following delivery. The major depressive episode must be diagnosed according to Mini International Neuropsychiatric Interview (MINI) 7.0 interview
* Given birth in the last 6 months
* HAMD17 score of ≥ 20 at screening but \< 26
* Must agree to stop breastfeeding from start of study treatment or must agree to temporarily cease giving breast milk to her infant(s)

Exclusion Criteria

* Current history of any psychotic illness, including major depressive episode with psychotic features
* History of suicide attempt within the past 3 years
* History of bipolar I disorder
* History of seizure discorder
Minimum Eligible Age

18 Years

Maximum Eligible Age

48 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Marinus Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Joseph Hulihan, MD

Role: STUDY_DIRECTOR

Marinus Pharmaceuticals

Locations

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Marinus Research Site

Glendale, California, United States

Site Status

Marinus Research Site

Lemon Grove, California, United States

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Marinus Research Site

Long Beach, California, United States

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Marinus Research Site

Oceanside, California, United States

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Marinus Research Site

Panorama City, California, United States

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Marinus Research Site

San Bernardino, California, United States

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Marinus Research Site

San Marcos, California, United States

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Marinus Research Site

Ventura, California, United States

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Marinus Research Site

Gainesville, Florida, United States

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Marinus Research Site

Hollywood, Florida, United States

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Marinus Research Site

Jacksonville, Florida, United States

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Marinus Research Site

North Miami, Florida, United States

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Marinus Research Site

Atlanta, Georgia, United States

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Marinus Research Site

Atlanta, Georgia, United States

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Marinus Research Site

Decatur, Georgia, United States

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Marinus Research Site

Marietta, Georgia, United States

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Marinus Research Site

Idaho Falls, Idaho, United States

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Marinus Research Site

Hoffman Estates, Illinois, United States

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Marinus Research Site

Leawood, Kansas, United States

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Marinus Research Site

Wichita, Kansas, United States

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Marinus Research Site

Flowood, Mississippi, United States

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Marinus Research Site

Las Vegas, Nevada, United States

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Marinus Research Site

Albuquerque, New Mexico, United States

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Marinus Research Site

Raleigh, North Carolina, United States

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Marinus Research Site

Englewood, Ohio, United States

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Marinus Research Site

Downingtown, Pennsylvania, United States

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Marinus Research Site

Media, Pennsylvania, United States

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Marinus Research Site

Houston, Texas, United States

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Marinus Research Site

Irving, Texas, United States

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Marinus Research Site

League City, Texas, United States

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Marinus Research Site

San Antonio, Texas, United States

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Marinus Research Site

Orem, Utah, United States

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Marinus Research Site

Richmond, Virginia, United States

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Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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1042-PPD-2003

Identifier Type: -

Identifier Source: org_study_id

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