CBART: The Reduction of Psychological and Physiological Stress in Women Undergoing IVF

NCT ID: NCT03459053

Last Updated: 2021-09-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

88 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-04-16

Study Completion Date

2021-08-01

Brief Summary

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The study is a randomized controlled trial of a cognitive behavioral interventions and an art-based stress reduction treatment protocol (CB-ART) with 100 women, identified with elevated perceived stress, before undergoing IVF treatment; in order to examine its effect on perceived stress, plasma CFD, telomere length and pregnancy rates.

CB-ART is a 6-session treatment protocol that has been utilized with women coping with stress, depression and pain and is effective in reducing these indicators, developed and evaluated by our research team. The treatment protocol emphasizes processing together with the client's recalled image, symptom or memory (ISM) pertaining to a current distressing mental or physical state. CB-ART is a multi-method model that integrates cognitive behavioral interventions and art-based stress reduction interventions. The innovation in this method is the transformation of imagined and drawn images and memories rather than solely verbally discussing their contents. The focus is on changing compositional elements that comprise each image and memory, thus providing a therapeutic venue to reframe and transform stress producing, recalled images and memories and reduce symptoms of perceived stress. Art making is beneficial for eliciting an emotional response and provides a concrete platform to conduct the cognitive processing that initiate change on the paper and then in the mind. Furthermore, the soothing qualities of interacting with art making foster and enhance behavioral relaxation techniques.

Our study population, women with infertility problems, who are designated to undergo IVF treatment and have been identified to have elevated perceived stress scores on the Perceived Stress Scale (above 15) will be randomized and allocated to receive the CB-ART intervention tailored to reduce stress or treatment as usual.

Detailed Description

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Conditions

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Psychological Stress DNA Degradation, Apoptotic Telomere Shortening Fertility Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Investigators Outcome Assessors
Research coordinator will conduct the randomization and all information will be deidentified. Investigator will not know who is in which group.

Study Groups

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CBART

6 weeks participation in CBART protocol before beginning IVF treatment

Group Type EXPERIMENTAL

CBART

Intervention Type BEHAVIORAL

Cognitive Behavioral protocol that uses art-making for stress reduction and cognitive interventions

Wait control

Participants will receive treatment as usual and will be able to receive the intervention after the study is complete.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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CBART

Cognitive Behavioral protocol that uses art-making for stress reduction and cognitive interventions

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Hebrew speaking nulliparous women
* between the ages of 18-35
* without an axis I psychiatric diagnosis

Exclusion Criteria

* Women over 35
* Do not speak Hebrew
* Have an Axis I psychiatric diagnosis that would prevent them from participating in the intervention
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Soroka University Medical Center

OTHER

Sponsor Role collaborator

Ben-Gurion University of the Negev

OTHER

Sponsor Role collaborator

Fondation de Myriam de Senarclens

UNKNOWN

Sponsor Role collaborator

University of Haifa

OTHER

Sponsor Role lead

Responsible Party

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Johanna Czamanski-Cohen

Lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Iris Harvardi, PhD

Role: PRINCIPAL_INVESTIGATOR

Soroka University Medical Center

Julie Cwikel, PhD

Role: PRINCIPAL_INVESTIGATOR

Ben-Gurion University of the Negev

Orly Sarid

Role: PRINCIPAL_INVESTIGATOR

Ben-Gurion University of the Negev

Locations

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Soroka University Medical Center

Beersheba, , Israel

Site Status

Countries

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Israel

References

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Czamanski-Cohen J, Sarid O, Cwikel J, Levitas E, Lunenfeld E, Douvdevani A, Har-Vardi I. Decrease in cell free DNA levels following participation in stress reduction techniques among women undergoing infertility treatment. Arch Womens Ment Health. 2014 Jun;17(3):251-3. doi: 10.1007/s00737-013-0407-2. Epub 2014 Jan 14.

Reference Type BACKGROUND
PMID: 24420416 (View on PubMed)

Czamanski-Cohen J, Sarid O, Cwikel J, Lunenfeld E, Douvdevani A, Levitas E, Har-Vardi I. Increased plasma cell-free DNA is associated with low pregnancy rates among women undergoing IVF-embryo transfer. Reprod Biomed Online. 2013 Jan;26(1):36-41. doi: 10.1016/j.rbmo.2012.09.018. Epub 2012 Oct 4.

Reference Type BACKGROUND
PMID: 23182744 (View on PubMed)

Czamanski-Cohen J, Sarid O, Cwikel J, Douvdevani A, Levitas E, Lunenfeld E, Har-Vardi I. Cell-free DNA and telomere length among women undergoing in vitro fertilization treatment. J Assist Reprod Genet. 2015 Nov;32(11):1697-703. doi: 10.1007/s10815-015-0581-4. Epub 2015 Oct 5.

Reference Type BACKGROUND
PMID: 26438644 (View on PubMed)

Sarid O, Cwikel J, Czamanski-Cohen J, Huss E. Treating women with perinatal mood and anxiety disorders (PMADs) with a hybrid cognitive behavioural and art therapy treatment (CB-ART). Arch Womens Ment Health. 2017 Feb;20(1):229-231. doi: 10.1007/s00737-016-0668-7. Epub 2016 Sep 19.

Reference Type BACKGROUND
PMID: 27645306 (View on PubMed)

Other Identifiers

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CBARTIVF

Identifier Type: -

Identifier Source: org_study_id

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