Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
66 participants
OBSERVATIONAL
2018-03-02
2019-07-19
Brief Summary
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Detailed Description
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84 patients will be measured. The cohort will be:
* 21 women less than 70
* 21 women more than 70
* 21 men less than 70
* 21 men more than 70 Measurement will be performed at radius and at tibia (ultra-distal and distal). For all the sites one measurement will be performed by HR-pQCT to get reference values of thickness and BMDs. For the distal positions and additional measurement will be performed by an innovative ultrasound device that estimates cortical thickness and porosity.
The participation to the study implies only a participation of one hour from the patient (30min for HR-pQCT measurements, 30 min for US).
The main objectives consist in :
* evaluating the age influence on cortical thickness at 1/3 distal radius measured by US
* evaluating the age influence on cortical thickness at distal tibia measured by US
* comparing porosities values measured by US to vBMD obtained by HR-pQCT
* comparing cortical thickness values measured by HR-pQCT at 1/3 distal radius position to ultra-distal radus position and to the tibia
* comparing vBMD values measured by HRpQCT at 1/3 distal radius position to ultra-distal radius position and to the tibia
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Bone measurement by HR-pQCT and ultrasound
Measurement will be performed at radius and at tibia (ultra-distal and distal). For all the sites one measurement will be performed by HR-pQCT to get reference values of thickness and BMDs. For the distal positions and additional measurement will be performed by an innovative ultrasound device that estimates cortical thickness and porosity.
Eligibility Criteria
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Inclusion Criteria
* coming from the rheumatology consultation at Lariboisière Hospital
Exclusion Criteria
* BMI \< 15
* cortisone treatment
* recent fracture at non-dominant arm
* wound on measuring zone
* treatment interfering with bone architecture or bone density : oral of transdermic oestrogenes, bisphosphonates (Alendronate, Risedronate, Zoledronate) or Denosumab during the past 6 months-
18 Years
ALL
No
Sponsors
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Assistance Publique - Hôpitaux de Paris
OTHER
Responsible Party
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Principal Investigators
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Cohen-Solal Martine, Martine
Role: PRINCIPAL_INVESTIGATOR
APHP
Locations
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Cohen-Solal
Paris, Île-de-France Region, France
Countries
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References
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Barkmann R, Kantorovich E, Singal C, Hans D, Genant HK, Heller M, Gluer CC. A new method for quantitative ultrasound measurements at multiple skeletal sites: first results of precision and fracture discrimination. J Clin Densitom. 2000 Spring;3(1):1-7. doi: 10.1385/jcd:3:1:001.
Bochud N, Vallet Q, Bala Y, Follet H, Minonzio JG, Laugier P. Genetic algorithms-based inversion of multimode guided waves for cortical bone characterization. Phys Med Biol. 2016 Oct 7;61(19):6953-6974. doi: 10.1088/0031-9155/61/19/6953. Epub 2016 Sep 12.
Zebaze RM, Ghasem-Zadeh A, Bohte A, Iuliano-Burns S, Mirams M, Price RI, Mackie EJ, Seeman E. Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet. 2010 May 15;375(9727):1729-36. doi: 10.1016/S0140-6736(10)60320-0.
Other Identifiers
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K 171006J
Identifier Type: -
Identifier Source: org_study_id
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