The FLOT Regimen Conversion Therapy of Adenocarcinoma of the Stomach / Gastroesophageal

NCT ID: NCT03451942

Last Updated: 2018-03-02

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 112 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-02-05
• Study Completion Date: 2021-03-31

Brief Summary

Evaluate survival benefit of surgical treatment after FLOT regimen conversion therapy of Her-2 Negative and single site metastasis adenocarcinoma of the stomach / gastroesophageal compared with chemotherapy, use relevant biomarkers to evaluate the efficacy of chemotherapy and seek for patients with Her-2 negative and metastatic adenocarcinoma of the stomach / gastroesophageal surviving benefit from surgical treatment after the FLOT regimen conversion therapy.

Conditions

Adenocarcinoma of the Stomach / Gastroesophageal

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

surgery group after FLOT regimen chemotherapy

After received 4 cycles FLOT regimen chemotherapy , D2 gastric resection and imaging metastases resection was performed. Then continue 4 cycles of FLOT regimen chemotherapy (Chemotherapy begins within 4-6 weeks after surgery)

Group Type: EXPERIMENTAL

FLOT regimen chemotherapy

Intervention Type: DRUG

FLOT regimen chemotherapy

D2 gastric and imaging metastases resection

Intervention Type: PROCEDURE

After received 4 cycles FLOT regimen chemotherapy , D2 gastric resection and imaging metastases resection was performed. Then continue 4 cycles of FLOT regimen chemotherapy (Chemotherapy begins within 4-6 weeks after surgery)

FLOT regimen chemotherapy

Continue 4 cycles of the FLOT regimen chemotherapy and evaluate the efficacy every 8 weeks.

Group Type: PLACEBO_COMPARATOR

FLOT regimen chemotherapy

Intervention Type: DRUG

FLOT regimen chemotherapy

Interventions

FLOT regimen chemotherapy

FLOT regimen chemotherapy

Intervention Type: DRUG

D2 gastric and imaging metastases resection

After received 4 cycles FLOT regimen chemotherapy , D2 gastric resection and imaging metastases resection was performed. Then continue 4 cycles of FLOT regimen chemotherapy (Chemotherapy begins within 4-6 weeks after surgery)

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. Patients volunteered to participate in this study and signed informed consent.

2. Endoscopic biopsy or metastatic biopsy was confirmed to be the adenocarcinoma of the stomach / gastroesophageal.

3. Her - 2 negative(Including: Her protein detection -/1+, and Her protein 2+ but FISH negative).

4. Without any antitumor therapy;

5. According to the 7th edition of AJCC, imaging (CT/MRI) confirmed that the adenocarcinoma of the stomach / gastroesophageal with the initial single site metastasis had a detectable lesion (according to the RECIST 1.1 standard); Single site metastasis includes: liver, spleen, pancreas, ovary, retroperitoneal lymph node (16a1/b2), adrenal gland, kidney;

6. Age from 18 to 70 years.

7. Eastern Cooperative Oncology Group(ECOG) performance status 0 or 1.

8. Life expectancy more than 12 weeks.

9. Histological specimens were provided for biological target detection of her-2;

10. Surgical patients agree to undergo surgery and sign an informed consent to perform the risk of surgery；

11. The main organ function meet the following criteria within 7 days before treatment:

• blood routine examination( No blood transfusion within 14 days)

1. HB≥90g/L，

2. ANC≥1.5×109/L，

3. PLT≥80×109/L；

• blood biochemical examination

1. TBIL <1.5 Upper Limit Of Normal（ULN）;

2. ALT and AST<2.5ULN(or ≤ 5×ULN in patients with liver metastases).

3. Cr≤1.5ULN or creatinine clearance>60ml/min.

• Doppler ultrasonography: left ventricular ejection fraction (LVEF) was lower than normal (50%).

12. Female subjects of child-bearing potential should agree to use contraceptive measures (such as intrauterine contraceptives, contraceptives or condoms) within six months of the study period and the end of the study. The serum or urine pregnancy test was negative within 7 days prior to the study and must be non-lactation. Men subjects should agree to use contraceptives in the study period and within six months at the end of the study period.

Exclusion Criteria

1. 5 years or at the same time have other malignant tumors；

2. docetaxel or oxaliplatin and other research with chemotherapy drugs are serious allergy;

3. patients with severe cachexia can not eat and can not tolerate chemotherapy and surgery;

4. During the screening period, there was an unknown cause of fever before the first administration and the body temperature was> 38.5 ° C (as judged by the investigators, cancer-related fever subjects could be enrolled);

5. Patients with any severe and / or uncontrollable disease, including:

1. Patients with hypertension who are not well controlled by antihypertensive medication (systolic BP ≥150 mmHg, diastolic BP ≥100 mmHg);

2. Myocardial ischemia or myocardial infarction with grade I or above, arrhythmia (including QTc≥480 ms) and ≥2 grade congestive heart failure (New York Heart Association (NYHA) classification);

3. Severe infection that is active or uncontrollable (≥CTCAE grade 2 infection);

4. Renal failure requires hemodialysis or peritoneal dialysis;

5. Have a history of immunodeficiency, including HIV-positive or other acquired, congenital immunodeficiency disease, or history of organ transplants;

6. Poor glycemic control in diabetic patients (fasting blood glucose (FBG)> 10 mmol / L);

7. Patients with seizures who require treatment;

6. Currently there are gastrointestinal diseases such as intestinal obstruction (including incomplete intestinal obstruction) or the researchers determine the patients may cause gastrointestinal bleeding, perforation or obstruction;

7. Within 4 weeks prior to enrollment, there were non-healing wounds, ulcers or fractures;

8. CNS metastasis;

9. Persons with psychiatric abuse who can not be abdicated or have mental disorders;

10. patients who have participated in other anti-cancer drug clinical trials within 4 weeks;

11. According to the judgment of the researcher, there is a concomitant disease which seriously endangers the safety of the patient or affects the patient in completing the study.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Henan Cancer Hospital

OTHER_GOV

Sponsor Role: lead

Responsible Party

LiuYing

Deputy Chief Physician

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ying Liu

Role: PRINCIPAL_INVESTIGATOR

Henan Cancer Hospital

Locations

Henan Cancer Hospital/The affiliated Cancer Hospital of ZhengZhou university

Zhengzhou, Henan, China

Countries

China

Other Identifiers

HNSZLG-GE-003

Identifier Type: -

Identifier Source: org_study_id