Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients

NCT ID: NCT03444259

Last Updated: 2024-05-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

1001 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-02-01

Study Completion Date

2029-12-31

Brief Summary

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The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.

Detailed Description

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The investigators aim to A) compare atrial cardiomyopathy findings from the tissue samples to clinical phenotype and adverse events B) study the association of genetic defects predisposing to atrial fibrillation with atrial cardiomyopathy findings in the tissue samples C) assess the role of inflammation in atrial fibrillation by comparing circulating cytokine profiles, purinergic signaling and atrial cardiomyopathy findings in tissue samples.

Conditions

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Atrial Fibrillation Coronary Artery Disease Aortic Valve Stenosis Aortic Valve Disease Mitral Valve Disease Cardiac Arrythmias Cardiac Tumor Cardiac Surgery

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Atrial fibrillation

Patients with atrial fibrillation

Cardiac surgery

Intervention Type PROCEDURE

Open heart surgery

Coronary bypass

Patients undergoing coronary bypass

Cardiac surgery

Intervention Type PROCEDURE

Open heart surgery

Aortic valve replacement

Patients undergoing aortic valve replacement

Cardiac surgery

Intervention Type PROCEDURE

Open heart surgery

Mitral valve repair

Patients undergoing mitral valve repair

Cardiac surgery

Intervention Type PROCEDURE

Open heart surgery

Other

Patients undergoing cardiac surgery for indication other than above

Cardiac surgery

Intervention Type PROCEDURE

Open heart surgery

Interventions

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Cardiac surgery

Open heart surgery

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Any open-heart cardiac surgery
* Written informed consent
* All-comers design

Exclusion Criteria

* No informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Brigham and Women's Hospital

OTHER

Sponsor Role collaborator

University of Turku

OTHER

Sponsor Role lead

Responsible Party

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Tuomas Kiviniemi

Cardiologist, MD, PhD, FESC

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Tuomas O Kiviniemi, MD, PhD

Role: STUDY_DIRECTOR

Turku University Hospital

Jarmo Gunn, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Turku University Hospital

Locations

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Turku University Hospital

Turku, , Finland

Site Status

Countries

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Finland

References

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Maaniitty E, Sinisilta S, Jalkanen J, Vasankari T, Biancari F, Gunn J, Jalkanen S, Airaksinen KEJ, Hollmen M, Kiviniemi T. Distinct circulating cytokine levels in patients with angiography-proven coronary artery disease compared to disease-free controls. Int J Cardiol Cardiovasc Risk Prev. 2024 Jul 4;22:200307. doi: 10.1016/j.ijcrp.2024.200307. eCollection 2024 Sep.

Reference Type DERIVED
PMID: 39091640 (View on PubMed)

Maaniitty E, Jalkanen J, Sinisilta S, Gunn J, Vasankari T, Biancari F, Jalkanen S, Airaksinen KEJ, Hollmen M, Kiviniemi T. Differential circulating cytokine profiles in acute coronary syndrome versus stable coronary artery disease. Sci Rep. 2024 Jul 27;14(1):17269. doi: 10.1038/s41598-024-68333-7.

Reference Type DERIVED
PMID: 39068298 (View on PubMed)

Viikinkoski E, Jalkanen J, Gunn J, Vasankari T, Lehto J, Valtonen M, Biancari F, Jalkanen S, Airaksinen KEJ, Hollmen M, Kiviniemi TO. Red blood cell transfusion induces abnormal HIF-1alpha response to cytokine storm after adult cardiac surgery. Sci Rep. 2021 Nov 15;11(1):22230. doi: 10.1038/s41598-021-01695-4.

Reference Type DERIVED
PMID: 34782683 (View on PubMed)

Other Identifiers

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T273/2015

Identifier Type: -

Identifier Source: org_study_id

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