Dose Ranging Study of RPL554 in Chronic Obstructive Pulmonary Disease (COPD) Patients

NCT ID: NCT03443414

Last Updated: 2019-06-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 405 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-06-01
• Study Completion Date: 2018-02-07

Brief Summary

The study investigates the effect of 4 weeks of twice daily treatment of four different doses of RPL554 (a phosphodiesterase [PDE]3/4 inhibitor) or placebo in patients with moderate to severe chronic obstructive pulmonary disease (COPD). Patients will be equally allocated to one of the five treatment options.

Detailed Description

RPL554 is a dual inhibitor of PDE3 and PDE4 which are known to have a role in modulating the inflammatory airway response in respiratory diseases, including COPD. PDE3 inhibitors act as bronchodilators whilst PDE4 inhibitors have anti-inflammatory properties and there is also evidence to suggest that combined inhibition of PDE3 and PDE4 can have additive or synergistic anti-inflammatory and bronchodilator effects. PDE4 inhibitors (administered orally) have, however been associated with unfavorable gastrointestinal side effects such as nausea, emesis, diarrhea, abdominal pain, loss of appetite and weight loss. Dual PDE3/PDE4 inhibitors (administered by inhalation) have exhibited both bronchodilator and anti-inflammatory actions, with a more favorable side effect profile. It is plausible that increased efficacy with reduced side effects may be achievable with administration of a dual PDE3/4 inhibitor by the inhaled route compared to orally administered PDE3 or PDE4 inhibitors.

The purpose of this study is to investigate the dose response of RPL554 in patients with COPD over 4 weeks. This length of time should allow for study of the bronchodilator response, measured predominantly by the peak forced expiratory volume in one second (FEV1), and the anti-inflammatory response, as measured predominantly by trough FEV1.

Conditions

COPD

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

0.75 mg RPL554

Group Type: EXPERIMENTAL

RPL554 suspension

Intervention Type: DRUG

A dual PDE3/PDE 4 inhibitor

1.5 mg RPL554

Group Type: EXPERIMENTAL

RPL554 suspension

Intervention Type: DRUG

A dual PDE3/PDE 4 inhibitor

3 mg RPL554

Group Type: EXPERIMENTAL

RPL554 suspension

Intervention Type: DRUG

A dual PDE3/PDE 4 inhibitor

6 mg RPL554

Group Type: EXPERIMENTAL

RPL554 suspension

Intervention Type: DRUG

A dual PDE3/PDE 4 inhibitor

Placebo

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

Placebo solution

Interventions

RPL554 suspension

A dual PDE3/PDE 4 inhibitor

Intervention Type: DRUG

Placebo

Placebo solution

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Provide informed consent
• Male or female aged 40 to 75 years
• Meeting specified contraception requirements
• 12-lead electrocardiogram with heart rate 50-90 beats per minute, QT interval corrected using Fridericia's formula (QTcF) ≤450 msec (males) or ≤470 msec (females), QRS interval ≤120 msec, PR interval ≤200 msec and no clinically significant abnormalities
• Capable of complying with all study restrictions and procedures, including ability to use the study nebulizer correctly.
• Body mass index (BMI) 18 to 35 kg/m2 and minimum weight 45 kg.
• COPD diagnosis with symptoms compatible with COPD for at least 1 year
• Clinically stable COPD in the previous 4 weeks
• Ability to perform acceptable and reproducible spirometry.
• Post-bronchodilator spirometry at screening must demonstrate FEV1/forced vital capacity (FVC) ratio of ≤0.70 and FEV1 must be ≥40 % to ≤80% of predicted normal
• Chest X-ray (posterior-anterior) at screening, or chest X-ray, magnetic resonance imaging (MRI) or computed tomography (CT) scan in the last 12 months, showing no abnormalities which are both clinically significant and unrelated to COPD.
• Meet the concomitant medication restrictions and be expected to do so for the rest of the study.
• Current and former smokers with a smoking history of ≥10 pack years.
• Capable of withdrawing long acting bronchodilators until the end of the treatment period, and short acting bronchodilators for 8 hours prior to administration of study medication.

Exclusion Criteria

• A history of life-threatening COPD including Intensive Care Unit admission and requiring intubation.
• COPD exacerbation requiring oral steroids in the previous 3 months
• A history of one or more hospitalizations for COPD in the previous 6 months
• Lower respiratory tract infection treated with antibiotics in the previous 3 months
• Evidence of cor pulmonale or clinically significant pulmonary hypertension.
• Patients with a current diagnosis of asthma, active tuberculosis, lung cancer, bronchiectasis, sarcoidosis, lung fibrosis, interstitial lung diseases, sleep apnea, known alpha-1 antitrypsin deficiency or other active pulmonary diseases.
• Previous lung resection or lung reduction surgery.
• Oral therapies for COPD (e.g. oral steroids, theophylline, and roflumilast) in the previous 3 months and throughout the study.
• Pulmonary rehabilitation, unless such treatment has been stable from 4 weeks prior to Visit 1) and remains stable during the trial.
• A history of, or reason to believe a subject has, drug or alcohol abuse in the previous 3 years.
• Received an experimental drug within 30 days or five half-lives of the first dose
• Prior exposure to RPL554.
• Women who are pregnant or breast-feeding.
• Patients with a history of current uncontrolled disease that the Investigator believes are clinically significant.
• myocardial infarction in the previous 6 month; congestive heart failure, a history of unstable or uncontrolled hypertension, or has been diagnosed with hypertension in last 3 months.
• Use of oral beta blockers.
• Major surgery (requiring general anesthesia) in the previous 6 weeks, lack of full recovery from surgery at screening, or planned surgery through the end of the study.
• History of malignancy of any organ system within 5 years, with the exception of localized skin cancers (basal or squamous cell).
• Clinically significant abnormal values for safety laboratory tests
• Significant non-compliance in previous investigational studies or with prescribed medications.
• Requirement for oxygen therapy, even on an occasional basis.
• Known hypersensitivity to RPL554 or its excipients/components.
• Abnormal clinically significant 12 lead Holter findings,
• Any other reason that the Investigator considers makes the subject unsuitable to participate.

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Verona Pharma plc

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Dr Singh

Role: PRINCIPAL_INVESTIGATOR

Medicines Evaluation Unit (MEU)

Locations

Clinic for pneumonology

Pleven, , Bulgaria

SHATPPD-Ruse EOOD

Rousse, , Bulgaria

Fifth MHAT - Sofia EAD

Sofia, , Bulgaria

MHAT 'Lyulin', EAD

Sofia, , Bulgaria

NMTH Tsar Boris III

Sofia, , Bulgaria

UMHAT 'Alexandrovska' EAD

Sofia, , Bulgaria

UMHAT 'Sveta Anna' AD

Sofia, , Bulgaria

Medical Center Nov

Stara Zagora, , Bulgaria

MediTrial s.r.o.

Jindřichův Hradec, , Czechia

Plicni stredisko Teplice

Teplice, , Czechia

Aerzte fuer Lungen- und

Berlin, , Germany

Charite Campus Mitte

Berlin, , Germany

emovis GmbH

Berlin, , Germany

Studienpraxis Berlin

Berlin, , Germany

IKF Pneumologie GmbH & Co. KG

Frankfurt, , Germany

Praxis Dr. Keller

Frankfurt, , Germany

Inamed GmbH

Gauting, , Germany

PRI Pulmonary Research

Großhansdorf, , Germany

Hamburger Institut fuer

Hamburg, , Germany

Gemeinschaftspraxis Dres

Koblenz, , Germany

POIS Leipzig GbR

Leipzig, , Germany

SALVUS UG Centre for Clinial Trials

Leipzig, , Germany

KLB Gesundheitsforschung

Lübeck, , Germany

Pneumologie Odeonsplatz

Munich, , Germany

Pneumologische Praxis Pasing

München, , Germany

Ballenberger Freytag Wenisch

Neu-Isenburg, , Germany

Dr. Christian Schlenska

Peine, , Germany

CERMED

Bialystok, , Poland

Indywidualna Specjalistyczna

Bialystok, , Poland

KLIMED Marek Klimkiewicz

Bychawa, , Poland

Silmedic sp. z o.o.

Katowice, , Poland

Grazyna Pulka Specjalistyczny

Krakow, , Poland

Malopolskie Centrum Alergologii

Krakow, , Poland

Centrum Terapii Wspólczesnej

Lodz, , Poland

Uniwersytecki Szpital Klin

Lodz, , Poland

NZOZ Alergo-MEDSpecjalistyczna

Poznan, , Poland

ETG Network Sp z o o

Skierniewice, , Poland

Centrum Medyczne Pratia

Warsaw, , Poland

Mazowieckie Centrum Medyczne

Warsaw, , Poland

Centrum Badan Klinicznych

Wroclaw, , Poland

Specjalistyczna Opieka

Wroclaw, , Poland

S.C Angisan S.R.L

Bragadiru, , Romania

S.C Clinica Pneumomedica S.R.L

Brasov, , Romania

Fundatia Dr. Victor Babes

Bucharest, , Romania

Spitalul Clinic de Urgenta

Bucharest, , Romania

Spitalul Cl. Pneumoftiziologie

Cluj-Napoca, , Romania

Spitalul CldePneumoftiziologie

Constanța, , Romania

Spitalul CldePneumoftiziologie

Iași, , Romania

Medicines Evaluation Unit

Manchester, , United Kingdom

Countries

Bulgaria; Czechia; Germany; Poland; Romania; United Kingdom

Provided Documents

Document Type: Statistical Analysis Plan

View Document

Document Type: Study Protocol

View Document

Other Identifiers

RPL554-CO-203

Identifier Type: -

Identifier Source: org_study_id