Impact of Rutin and Vitamin C Combination on Oxidative Stress, Insulin Sensitivity and Lipid Profile in Type 2 Diabetic Patients
NCT ID: NCT03437902
Last Updated: 2018-05-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2/PHASE3
53 participants
INTERVENTIONAL
2018-02-24
2018-05-15
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Rutin C group
patients will receive Rutin 60 mg in combination with vitamin C 160 mg three times daily in addition to usual antidiabetic treatment for 8 weeks..
Rutin in combination with Vitamin C
Rutin and Vitamin C will be supplied as tablets containing 60 mg Rutin and 160 mg Vitamin C. The use of Rutin and Vitamin C will be under the trade name of RUTA C 60 ® manufactured by KAHIRA PHARM.\& CHEM. IND. Company
Vitamin C group
patients will receive vitamin C 500 mg once daily in addition to usual antidiabetic treatment for 8 weeks.
Vitamin C
Vitamin C will be supplied as capsules containing500 mg of Vitamin C. The use of Vitamin C will be under the trade name of C-Retard ® manufactured by HIKMA Quality Company.
Control group
patients will receive their usual antidiabetic treatment only for 8 weeks.
No interventions assigned to this group
Interventions
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Rutin in combination with Vitamin C
Rutin and Vitamin C will be supplied as tablets containing 60 mg Rutin and 160 mg Vitamin C. The use of Rutin and Vitamin C will be under the trade name of RUTA C 60 ® manufactured by KAHIRA PHARM.\& CHEM. IND. Company
Vitamin C
Vitamin C will be supplied as capsules containing500 mg of Vitamin C. The use of Vitamin C will be under the trade name of C-Retard ® manufactured by HIKMA Quality Company.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Patients taking oral diabetic medications (Sulfonylurea) not taking Insulin.
* Able to understand and willing to sign a written informed consent document
Exclusion Criteria
• use of vitamin supplements containing vitamin C or other antioxidants.
* patients with renal or hepatic failure.
* patients taking insulin as antidiabetic treatment
35 Years
ALL
No
Sponsors
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Ain Shams University
OTHER
Responsible Party
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sara ramzy ragheb
Assistant Lecturer
Principal Investigators
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sara R Ragheb, master
Role: PRINCIPAL_INVESTIGATOR
Ain Shams University
Locations
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Ain Shams University
Cairo, , Egypt
Countries
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References
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Ragheb SR, El Wakeel LM, Nasr MS, Sabri NA. Impact of Rutin and Vitamin C combination on oxidative stress and glycemic control in patients with type 2 diabetes. Clin Nutr ESPEN. 2020 Feb;35:128-135. doi: 10.1016/j.clnesp.2019.10.015. Epub 2019 Nov 14.
Other Identifiers
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PHCL39
Identifier Type: -
Identifier Source: org_study_id
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