Role of Multislice CT in Diagnosis of Inflammatory Bowel Disease

NCT ID: NCT03436966

Last Updated: 2018-02-20

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-10-31
• Study Completion Date: 2019-10-31

Brief Summary

Aim of the work: To evaluate the role of CT in diagnosis of IBD

Detailed Description

Inflammatory bowel disease (IBD): is a chronic idiopathic disease affecting the gastrointestinal (GI) tract that is comprised of two separate, but related intestinal disorders; Crohn s disease (CD) and ulcerative colitis (UC), IBD is thought to result from an exaggerated and inappropriate immune response to gut luminal microbes in genetically, susceptible individuals who are exposed to environmental risk factors. IBD is most common in North America and western and northern Europe, where incidence rates for UC and CD range from 2.2-24.3 per 100000 person years, It is estimated that more than 1.4 million Americans and as many as 2.5-3 million, Europeans have IBD. While UC and CD share some features, the diseases are distinct. Perhaps the most important differences are that while the chronic inflammation seen in UC is limited to the large intestine and affects only the intestinal mucosa, the inflammation in CD can occur at any location(s) along the GI tract and is often transmural, predisposing patients with CD to the development of penetrating (fistulizing) and fibro stenotic (stricturing) phenotypes that are not typically seen in UC. In some cases, UC and CD are not distinguishable and a diagnosis of IBD unclassified (IBD-U) is made although clinical features of IBD-U tend to mirror those of UC Clinical manifestations of UC include diarrhea, with or without blood, abdominal pain, tenesmus, and fecal urgency, while the manifestations of CD are more variable depending on the extent and location of the GI inflammation. CD with predominantly colonic involvement often presents in similar fashion to UC whereas in small bowel CD, diarrhea and rectal bleeding are seen less frequently and symptoms, fever, fatigue and weight loss are common.

Conditions

Inflammatory Bowel Diseases

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

MULTI SLICE CT

Positive enteric contrast, can, however, obscure IV contrast enhancement of the bowel wall. In addition, positive oral contrast agents opacify but do not always well distend the bowel. IV contrast is administered and images are acquired in the portal venous phase, which is optimized for visceral organ evaluation.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Patient in the age group between 15&40 and another age group between 50&80 with inflammatory bowel disease.

Exclusion Criteria

• Patients with any general contraindication to Radiation of CT especially pregnant women.
• Patients with any general contraindication to contrast, impaired renal function & hypersensitivity.
• Patients of the age group below 15 years old.

• Minimum Eligible Age: 15 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Heba Abo Elmakarem Ahmed

Principle investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

shreef abd, prof

Role: STUDY_DIRECTOR

Assiut University

Central Contacts

HMakarem am, residant

Role: CONTACT

hoobamakarem@gmail.com

01122112561

Mzidan z, Asst.prof

Role: CONTACT

mzidan74@yahoo.com

01001121365

References

Loftus EV Jr. Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology. 2004 May;126(6):1504-17. doi: 10.1053/j.gastro.2004.01.063.

Reference Type: RESULT

PMID: 15168363 (View on PubMed)

Other Identifiers

MSCT in IBD

Identifier Type: -

Identifier Source: org_study_id