Effect of Diet and Physical Activity on Adipokines

NCT ID: NCT03435978

Last Updated: 2018-02-19

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 66 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-01-01
• Study Completion Date: 2018-01-03

Brief Summary

The prevalence of metabolic syndrome (MetS) in young population continues to rise. Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to determine whether these adipokines are significant markers in defining MetS in pediatric population and to assess the effect of hypocaloric diet and physical activity on serum concentrations of adiponectine, leptin, and high sensitivity CRP (hs-CRP).

Detailed Description

The idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. Currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. Communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) Adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.The prevalence of metabolic syndrome (MetS) in young population continues to rise. Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to determine whether these adipokines are significant markers in defining MetS in pediatric population and to assess the effect of hypocaloric diet and physical activity on serum concentrations of adiponectine, leptin, and high sensitivity CRP (hs-CRP).

The investigators tested the hypothesis that long-term lifestyle changes and moderate weight loss would reduce the plasma concentrations of adipokines involved in inflammation, angiogenesis, and chemotaxis and would increase adiponectin concentrations.

Material and methods:

A prospective study was conducted over a period of 1 year, between January 2016 and December 2016, on 66 cases of obesity in children diagnosed at the Louis Ţurcanu Emergency Hospital for Children Timisoara. The patients diagnosed with MetS were put on diet and physical exercise for 3 months.

Conditions

Obesity, Metabolically Benign

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

MetS+

Obese group with metabolic syndrome/Data processing from Patient Medical Files

MetS+

Intervention Type: BEHAVIORAL

MetS-

Obese group without metabolic syndrome/Data processing from Patient Medical Files

MetS-

Intervention Type: OTHER

Data processing from Patient Medical Files

Interventions

MetS+

Intervention Type: BEHAVIORAL

MetS-

Data processing from Patient Medical Files

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• obese children (BMI> 95th percentile)

Exclusion Criteria

• obesity caused by endocrine disease, syndromic obesity, systemic disease or acute illness.

• Minimum Eligible Age: 5 Years
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Medicine and Pharmacy "Victor Babes" Timisoara

OTHER

Sponsor Role: collaborator

Louis Turcanu Emergency Hospital for Children

OTHER

Sponsor Role: lead

Responsible Party

Ramona Stroescu

MD,PhD,Clinical Researcher

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Mihai Gafencu, Md,PhD

Role: PRINCIPAL_INVESTIGATOR

Louis Turcanu Emergency Hospital for Children

References

Beyazit F, Unsal MA. Obesity and insulin resistance are significant predictors of serum leptin levels. J Turk Ger Gynecol Assoc. 2017 Sep 1;18(3):158-159. doi: 10.4274/jtgga.2017.0027. No abstract available.

Reference Type: BACKGROUND

PMID: 28890432 (View on PubMed)

Bagherniya M, Khayyatzadeh SS, Heidari Bakavoli AR, Ferns GA, Ebrahimi M, Safarian M, Nematy M, Ghayour-Mobarhan M. Serum high-sensitive C-reactive protein is associated with dietary intakes in diabetic patients with and without hypertension: a cross-sectional study. Ann Clin Biochem. 2018 Jul;55(4):422-429. doi: 10.1177/0004563217733286. Epub 2017 Nov 23.

Reference Type: BACKGROUND

PMID: 28882065 (View on PubMed)

Other Identifiers

13200

Identifier Type: -

Identifier Source: org_study_id