Dexmedetomidine for Bilateral Superficial Cervical Plexus Block for Reconstructive Tracheal Surgery
NCT ID: NCT03426527
Last Updated: 2020-09-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
80 participants
INTERVENTIONAL
2018-03-01
2018-10-01
Brief Summary
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Bilateral superficial cervical plexus block (BSCPB) is a popular regional anesthesia technique for its feasibility and efficacy. The use of regional anesthesia in combination with general anesthesia may lighten the level of general anesthesia required , provide prolonged postoperative analgesia and reduce the requirements for opioid analgesics
Dexmedetomidine is a highly selective α2 agonist with high affinity for α2 adrenergic receptors and less α1 effects, which is responsible for the hypnotic and analgesic effects. Previous trials demonstrated that perineural dexmedetomidine in combination with bupivacaine enhanced sensory and motor block ,without neurotoxicity ,in both experimental and clinical studies.
Levobupivacaine, is "S"-enantiomer of bupivacaine, has strongly emerged as a safer alternative for regional anesthesia than bupivacaine . Levobupivacaine has been found to be equally efficacious as bupivacaine, but with a superior pharmacokinetic profile.
Clinically, levobupivacaine has been observed to be well tolerated in regional anesthesia techniques both after bolus administration and continuous post-operative infusion.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
DOUBLE
Study Groups
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Levobupivacaine
Patients will receive bilateral superficial cervical plexus block using levobupivacaine General anesthesia
Levobupivacaine
Following induction of anaesthesia, patients will receive ultrasound guided bilateral superficial cervical plexus block with levobupivacaine
General Anaesthesia
Using propofol, fentanyl and atracurium
Levobupivacaine-Dexmedetomidine
Patients will receive bilateral superficial cervical plexus block using levobupivacaine-dexmedetomidine General anesthesia
Levobupivacaine-Dexmedetomidine
Following induction of anaesthesia, patients will receive ultrasound guided bilateral superficial cervical plexus block with levobupivacaine in conjunction with dexmedetomidine
General Anaesthesia
Using propofol, fentanyl and atracurium
Interventions
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Levobupivacaine
Following induction of anaesthesia, patients will receive ultrasound guided bilateral superficial cervical plexus block with levobupivacaine
Levobupivacaine-Dexmedetomidine
Following induction of anaesthesia, patients will receive ultrasound guided bilateral superficial cervical plexus block with levobupivacaine in conjunction with dexmedetomidine
General Anaesthesia
Using propofol, fentanyl and atracurium
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Coagulation disorders
* Pregnancy
* Postpartum period.
* Lactating females
* Local sepsis
18 Years
40 Years
ALL
No
Sponsors
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Mansoura University
OTHER
Responsible Party
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Principal Investigators
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Salwa MS Hayes, MD
Role: STUDY_CHAIR
Assistant Professor, MD anesthesia Department, Faculty of Medicine, Mansoura University, Egypt.
Locations
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Mansoura University, Central Hospital, Oto-Rhino-Laryngology anesthesia Unit
Al Mansurah, DK, Egypt
Countries
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Other Identifiers
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R/17.09.19
Identifier Type: -
Identifier Source: org_study_id
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