Nutrition and Outcomes of Hematopoietic Cell Transplantation (HCT)

NCT ID: NCT03419078

Last Updated: 2019-10-21

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

484 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-12-31

Study Completion Date

2016-11-30

Brief Summary

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Retrospective case-note review to determine if nutrition via the enteral compared to the parenteral route results in better outcomes after haematopoietic cell transplantation.

Detailed Description

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This is a retrospective case-note review of adults undergoing haematopoietic cell transplantation to treat a haematological malignancy who have been admitted to Hammersmith Hospital from 2000 to 2014. All patients receiving an allogeneic haematopoietic cell transplant from a matched sibling or identically matched unrelated donor will be included. We will record the route and assess the broad adequacy of nutritional intakes to determine if nutrition via the enteral compared to the parenteral route results in better outcomes after haematopoietic cell transplantation. Our outcomes are graft versus host disease incidence and severity, transplant related (early) mortality and overall survival.

Conditions

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Allogeneic Stem Cell Transplant Graft Versus Host Disease Hematologic Malignancy Stem Cell Transplant Complications

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing their first HCT for a hematologic malignancy
* Undergoing HCT using a sibling or unrelated donor
* Undergoing HCT infusion between January 2000 and December 2014

Exclusion Criteria

* HCT using umbilical cord blood donors
* HCT using haploidentical donors
Minimum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Imperial College Healthcare NHS Trust

OTHER

Sponsor Role lead

Responsible Party

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JBeckerson

Haemato-Oncology Specialist Dietitian

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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15HH2638

Identifier Type: -

Identifier Source: org_study_id

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