Cryolesion in Treatment of Phantom Limb Pain

NCT ID: NCT03415360

Last Updated: 2018-09-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-09

Study Completion Date

2020-01-31

Brief Summary

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Assessment of pain intensity on the NRS. Assessment of the quality of life by SF-36 and AIS. Diagnostic/prognostic nerve block with 5 ml of 2% lidocaine under real-time ultrasound control with confirmation of the correct position of the needle using a peripheral nerve stimulator.

Reassessment of pain intensity on the NRS 30 minutes after local anesthetic block.

Cryoablation under real-time ultrasound control if the NRS value is reduced by ≥ 2 points.

If pain intensity on the NRS reduced by less than 2 points, reassessment 60 minutes after local anesthetic block.

Cryoablation under real-time ultrasound control if the NRS value is reduced by ≥ 2 points.

If pain intensity on the NRS reduces by less than 2 points 60 minutes after local anesthetic block cryoablation will not be performed.

Cryoablation effect will be evaluated 24 hours, 7 days, 30 days, 3 months, 6 months post procedure.

* 24 hours after the procedure - assessment of pain intensity and quality of life
* 7 days after the procedure - assessment of pain intensity
* 30 days after the procedure - assessment of pain intensity and quality of life
* 3 months after the procedure - assessment of pain intensity
* 6 months after the procedure - assessment of pain intensity and quality of

Detailed Description

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Conditions

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Phantom Limb Pain Stump Neuralgia Pain, Phantom

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Single Group Assignment
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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cryoablation

peripheral nerve cryoablation

Group Type OTHER

cryoablation

Intervention Type PROCEDURE

cryoablation of nerve responsible for phantom limb pain

Interventions

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cryoablation

cryoablation of nerve responsible for phantom limb pain

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Status post amputation of a lower or upper limb
* Pain related to amputation as determined by referring physician and investigator
* Informed consent of patient to enter the study
* Reduction of pain after the diagnostic/prognostic anesthetic block of the relevant main peripheral nerves under ultrasonography guidance in an analogous fashion to the cryoablation procedure

Exclusion Criteria

* Pregnancy
* Active infection in the area of the planned intervention
* Blood coagulation disorders
* Immunosuppression
* Significant spinal stenosis or spinal anomalies that result in differential nerve root pressures
* Significant disease or disorder that in the opinion of the Principal Investigator would preclude the safe performance of the anesthetic block or cryoablation
* Participation in another investigational trial involving systemic administration of agents of unknown chemical composition.
* No reduction of pain after the diagnostic block of the relevant main peripheral nerves
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Military Institute od Medicine National Research Institute

OTHER

Sponsor Role lead

Responsible Party

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Dariusz Tomaszewski

Adjunct professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dariusz Tomaszewski

Role: STUDY_CHAIR

Military Institute of Medicine

Locations

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Military Institute of Medicine

Warsaw, , Poland

Site Status RECRUITING

Countries

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Poland

Central Contacts

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Dariusz Tomaszewski, MD PhD

Role: CONTACT

00 48501 190 386

Jaroslaw J Les, MD PhD

Role: CONTACT

00 48 695 926 026

Facility Contacts

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Jaroslaw Les, MD, PhD

Role: primary

+48 216816895

Other Identifiers

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681006-6

Identifier Type: -

Identifier Source: org_study_id

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