Differences in Immunologic Response to Cryoablation Versus Radiofrequency Ablation in the Treatment of Renal Cell Carcinoma

NCT ID: NCT03409224

Last Updated: 2021-04-19

Basic Information

• Recruitment Status: TERMINATED
• Total Enrollment: 53 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2003-01-31
• Study Completion Date: 2019-04-30

Brief Summary

The purpose of this study is to compare changes in the body's self-defense (immune response) after two different treatments for small kidney tumors: 1) Cryoablation (freezing) therapy in which the tumor and a margin of normal kidney tissue are frozen and thawed twice with a needle probe and 2) radiofrequency ablation (RFA) in which radiofrequency energy delivered through a needle probe is used to heat tissue and thereby destroy a tumor.

Conditions

Immune Response to 3 Approaches

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Adults 18-99

Adults who are undergoing cryoablation

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• You are eligible to participate in this study if you are an adult (older than 18 years)
• Diagnosed with renal cell cancer 1-3 centimeters in size on the CT scan.

Exclusion Criteria

• You are not eligible to participate in this study if you are immune compromised (chemotherapy,corticosteroid use, HIV [as documented in your medical record], etc.)
• Have an autoimmune disorders (Rheumatoid arthritis, Crohn's disease, etc)
• Have a tumor larger than 4 cm
• Are pregnant.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 99 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of California, Irvine

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Other Identifiers

2009-6735

Identifier Type: -

Identifier Source: org_study_id