Carbohydrate Content in the Diet in Type 1 Diabetes

NCT ID: NCT03400618

Last Updated: 2023-04-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

54 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-03-01

Study Completion Date

2022-12-31

Brief Summary

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The aim of this study is to analyse the effect of a diet with a moderate amount of carbohydrates and compare it with a traditional diabetic diet with a higher content of carbohydrates on mean glucose level, high and low glucose levels, and the risk of ketoacidosis in patients with type 1 diabetes. The glucose levels will be measured by blinded continuous glucose monitoring (CGM).

The trial has a cross-over design and 12 weeks in duration, where patients will be randomized to; 1) a diet with moderate carbohydrate content for 4 weeks and 2) a traditional diabetes diet for 4 weeks and with a wash-out period between for 4 weeks. The two diets will both be healthy and planned by a dietitian. There will be 50 subjects included in the study.

Detailed Description

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Conditions

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Diabetes Mellitus, Type 1

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Moderate carbohydrate diet

A healthy diet containing 30 E % carbohydrates

Group Type EXPERIMENTAL

Moderate carbohydrate diet

Intervention Type OTHER

30 E % carbohydrates included in the diet

Higher carbohydrate diet

A healthy diet containing 50 E % carbohydrates

Group Type EXPERIMENTAL

Higher carbohydrate diet

Intervention Type OTHER

50 E % carbohydrates included in the diet

Interventions

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Moderate carbohydrate diet

30 E % carbohydrates included in the diet

Intervention Type OTHER

Higher carbohydrate diet

50 E % carbohydrates included in the diet

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Type 1 diabetes
* Adults 18 years or older
* Written Informed Consent
* HbA1c ≥ 58 mmol/mol (7,5 % DCCT standard)

Exclusion Criteria

* Pregnancy or planned pregnancy for the study duration
* Severe cognitive dysfunction or other disease, which is judged by the physician to be not suitable for inclusion
* Problems with compliance to the intervention diets (excluding a lot of the foods that are common in the diets like wholegrain/beans/lentils/fruit/vegetables) because of personal preferences, other diseases, stomach problems etc.
* Diabetes duration \< 1 year
* Planned change in diabetes treatment (eg. Start with insulin pump, CGM etc.) during the study period
* Other investigator-determined criteria unsuitable for patient participation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Vastra Gotaland Region

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marcus Lind, PhD

Role: PRINCIPAL_INVESTIGATOR

NU Hospital Organization/University of Gothenburg

Locations

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NU Hospital Organization

Uddevalla, , Sweden

Site Status

Countries

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Sweden

References

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Sterner Isaksson S, Olafsdottir AF, Lind M. Design of a randomized cross-over study evaluating effects of carbohydrate intake on glycemic control in persons with type 1 diabetes. Front Nutr. 2023 Mar 13;10:1114317. doi: 10.3389/fnut.2023.1114317. eCollection 2023.

Reference Type DERIVED
PMID: 36992911 (View on PubMed)

Other Identifiers

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Carbohydrate study

Identifier Type: -

Identifier Source: org_study_id

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