Long-term Effects of Intensive Insulin Treatment in Type 1 Diabetes
NCT ID: NCT02138006
Last Updated: 2016-10-24
Study Results
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View full resultsBasic Information
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COMPLETED
NA
102 participants
INTERVENTIONAL
1982-09-30
2011-12-31
Brief Summary
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Detailed Description
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In the present interventional study we wanted to study all-cause mortality and cardiovascular outcomes (i.e. myocardial infarction and stroke), and renal failure in the SDIS cohort until december 31 2011.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Intensive insulin treatment
Intensive insulin treatment
Intensive insulin treatment
Mealtime insulin (Actrapid) Basal insulin (Monotard)
Standard insulin treatment
Standard insulin treatment
Standard insulin treatment
Insulin Mixtard
Interventions
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Intensive insulin treatment
Mealtime insulin (Actrapid) Basal insulin (Monotard)
Standard insulin treatment
Insulin Mixtard
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Type 1 diabetes
* Nonproliferative retinopathy
* Normal serum creatinine
* Unsatisfactory blood glucose control
Exclusion Criteria
* Proliferative retinopathy
18 Years
52 Years
ALL
No
Sponsors
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Karolinska Institutet
OTHER
Responsible Party
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Thomas Nystrom
dr
Principal Investigators
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Thomas Nyström, Md, PhD
Role: PRINCIPAL_INVESTIGATOR
Karolinska Institutet Dept of clinical science and education Södersjukhuset Stocholm
Locations
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Södersjukhuset
Stockholm, , Sweden
Countries
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References
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Reichard P, Nilsson BY, Rosenqvist U. The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. N Engl J Med. 1993 Jul 29;329(5):304-9. doi: 10.1056/NEJM199307293290502.
Jensen-Urstad KJ, Reichard PG, Rosfors JS, Lindblad LE, Jensen-Urstad MT. Early atherosclerosis is retarded by improved long-term blood glucose control in patients with IDDM. Diabetes. 1996 Sep;45(9):1253-8. doi: 10.2337/diab.45.9.1253.
Reichard P, Britz A, Cars I, Nilsson BY, Sobocinsky-Olsson B, Rosenqvist U. The Stockholm Diabetes Intervention Study (SDIS): 18 months' results. Acta Med Scand. 1988;224(2):115-22. doi: 10.1111/j.0954-6820.1988.tb16748.x.
Reichard P, Pihl M. Mortality and treatment side-effects during long-term intensified conventional insulin treatment in the Stockholm Diabetes Intervention Study. Diabetes. 1994 Feb;43(2):313-7. doi: 10.2337/diab.43.2.313.
Rathsman B, Jensen-Urstad K, Nystrom T. Intensified insulin treatment is associated with improvement in skin microcirculation and ischaemic foot ulcer in patients with type 1 diabetes mellitus: a long-term follow-up study. Diabetologia. 2014 Aug;57(8):1703-10. doi: 10.1007/s00125-014-3248-2. Epub 2014 May 7.
Other Identifiers
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EPN-2012
Identifier Type: -
Identifier Source: org_study_id
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