Losartan and Emotion Processing

NCT ID: NCT03396523

Last Updated: 2018-06-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-01-04

Study Completion Date

2018-12-31

Brief Summary

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The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear

Detailed Description

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In a double-blind, between-subject, placebo controlled design the effects of a single dose of losartan (50mg) on fear extinction in healthy male participants will be examined. Participants will initially undergo a Pavlovian fear conditioning procedure, followed by the administration of 50mg losartan or placebo. 90 minutes after treatment subjects will undergo the fear extinction procedure. Neural activity and psychophysiological indices of arousal will be assessed by the simultaneous acquisition of functional magnetic resonance imaging (fMRI) and skin conductance data.

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Losartan group

Group Type EXPERIMENTAL

Losartan

Intervention Type DRUG

administration of losartan (50 mg) (oral)

Placebo group

Group Type PLACEBO_COMPARATOR

Placebo Oral Tablet

Intervention Type DRUG

administration of placebo (oral)

Interventions

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Losartan

administration of losartan (50 mg) (oral)

Intervention Type DRUG

Placebo Oral Tablet

administration of placebo (oral)

Intervention Type DRUG

Other Intervention Names

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Cozaar Oral Tablet

Eligibility Criteria

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Inclusion Criteria

* Healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria

* history of head injury
* medical or psychiatric illness
* hypertension
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Electronic Science and Technology of China

OTHER

Sponsor Role lead

Responsible Party

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Benjamin Becker

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Benjamin Becker, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Electronic Science and Technology of China

Locations

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University of Electronic Science and Technology of China

Chengdu, Sichuan, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Weihua Zhao, Master

Role: CONTACT

86-28-61830811

Facility Contacts

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Weihua Zhao, Master

Role: primary

References

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Zhou F, Geng Y, Xin F, Li J, Feng P, Liu C, Zhao W, Feng T, Guastella AJ, Ebstein RP, Kendrick KM, Becker B. Human Extinction Learning Is Accelerated by an Angiotensin Antagonist via Ventromedial Prefrontal Cortex and Its Connections With Basolateral Amygdala. Biol Psychiatry. 2019 Dec 15;86(12):910-920. doi: 10.1016/j.biopsych.2019.07.007. Epub 2019 Jul 25.

Reference Type DERIVED
PMID: 31471037 (View on PubMed)

Other Identifiers

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UESTC-neuSCAN-25

Identifier Type: -

Identifier Source: org_study_id

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