Study to Assess the Safety and Immunogenicity of a Chikungunya Virus Vaccine Candidate (VLA1553) in Healthy Volunteers

NCT ID: NCT03382964

Last Updated: 2019-08-29

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 120 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-03-05
• Study Completion Date: 2019-07-28

Brief Summary

Randomized, observer-blinded, multicenter, dose-escalation Phase 1 clinical study investigating three dose levels of VLA1553 after a single immunization.

120 study participants will be enrolled into the study to receive three different doses (30 subjects in the low and medium and 60 subjects in the high dose group). Vaccination will be given intramuscularly on Day 0. As safety precaution, the study will begin with enrolment of 20 sentinel subjects in an open-label fashion. Thereafter, subjects will be enrolled in a blinded, randomized manner in the three study arms.

A re-vaccination will be given at Month 6 or Month 12 to confirm that a single vaccination will be sufficient to induce high titer neutralizing antibodies and protect subjects from CHIKV viremia.

Study participants will be followed up until 13 months after initial vaccination.

Conditions

Chikungunya

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: DOUBLE

Study Groups

VLA1553 low dose

VLA1553 with 3.2x10\^3 TCID50/ 100 µL (microliter). Re-vaccination at Month 12 with VLA1553 with 3.2x10\^5 TCID50/ 1 mL (milliliter)

Group Type: ACTIVE_COMPARATOR

VLA1553

Intervention Type: BIOLOGICAL

I.M. vaccination with a live-attenuated Chikungunya virus (CHIKV) vaccine candidate

VLA1553 medium dose

VLA1553 with 3.2x10\^4 TCID50/ 1 mL Re-vaccination at Month 12 with VLA1553 with 3.2x10\^5 TCID50/ 1 mL

Group Type: ACTIVE_COMPARATOR

VLA1553

Intervention Type: BIOLOGICAL

I.M. vaccination with a live-attenuated Chikungunya virus (CHIKV) vaccine candidate

VLA1553 high dose

VLA1553 with 3.2x10\^5 TCID50/ 1 mL Re-vaccination at Month 6 or Month 12 with VLA1553 with 3.2x10\^5 TCID50/ 1 mL

Group Type: ACTIVE_COMPARATOR

VLA1553

Intervention Type: BIOLOGICAL

I.M. vaccination with a live-attenuated Chikungunya virus (CHIKV) vaccine candidate

Interventions

VLA1553

I.M. vaccination with a live-attenuated Chikungunya virus (CHIKV) vaccine candidate

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

• Aged 18 to 45 years on the Day of screening;
• Has a BMI of ≥ 18.5 and < 30 kg/m2 on the Day of screening;
• Understanding of the study and its procedures, agrees to its provisions, and gives written informed consent prior to any study-related procedures;
• Generally healthy as determined by the Investigator's clinical judgement based on medical history, physical examination and screening laboratory tests;
• If female, subject is of non-childbearing potential. The definition of non-childbearing potential includes the following:

1. Surgically sterile (e.g., hysterectomy with or without oophorectomy; fallopian tube ligation; endometrial ablation), at least 30 days prior to signature of the Informed Consent form;

2. At least 5 years post-menopause (i.e., 6 years post last menstrual period), or menopause confirmed by follicle-stimulating hormone (FSH) testing.

Exclusion Criteria

• History of known CHIKV infection;
• Plans to travel to areas with active CHIKV transmission during the course of the study or history of travel to an endemic CHIKV area within 4 weeks prior to study enrollment;
• Participation in a clinical study involving an investigational CHIKV vaccine;
• Receipt of an inactivated vaccine within 4 weeks or live vaccine within 8 weeks prior to vaccination in this study;
• Positive test results for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV);
• (1) Abnormal laboratory liver function values (≥ grade 1), (2) any grade 1 abnormal lab values deemed clinically relevant by the Investigator, and (3) any ≥ grade 2 abnormal lab values irrespective of clinical significance at screening;
• Clinically significant abnormal ECG at screening;
• History of significant cardiovascular, respiratory (including asthma), metabolic, neurological, hepatic, rheumatic, autoimmune, hematological, gastrointestinal or renal disorder;
• History of immune-mediated or clinically significant arthritis/arthralgia;
• History of malignancy other than squamous cell or basal cell skin cancer, unless there has been surgical excision that is considered to have achieved a cure;
• Disease or recent or current treatment that can be expected to influence immune response as specified in the protocol;
• History of severe hypersensitivity reactions or anaphylaxis;
• History of any vaccine related contraindicating event (e.g., anaphylaxis, allergy to components of the candidate vaccine, other known contraindications);
• Acute febrile infections within two weeks prior to vaccination;
• Subject is of childbearing potential or lactating at the time of enrollment;
• Blood donation within 30 days or receipt of blood-derived products (e.g. plasma) within 90 days prior to vaccination in this study or during the course of the study;
• A rash, dermatological condition or tattoos that would, in the opinion of the Investigator, interfere with injection site reaction rating;
• Known or suspected problem with alcohol or drug abuse as determined by the Investigator;
• Any condition that, in the opinion of the Investigator, may compromise the subjects well-being, might interfere with evaluation of study endpoints, or would limit the subject's ability to complete the study;
• Participation in another clinical study involving an investigational medicinal product within 30 days prior to study enrollment or during the course of this study;
• Member of the team conducting the study or in a dependent relationship with one of the study team members. Dependent relationships include close relatives (i.e., children, partner/spouse, siblings, parents) as well as employees of the Investigator or site personnel conducting the study.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Valneva Austria GmbH

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Nina Wressnigg

Role: STUDY_CHAIR

Valneva Austria GmbH

Locations

Optimal Research, LLC

Huntsville, Alabama, United States

Optimal Research, LLC

Peoria, Illinois, United States

Countries

United States

References

Wressnigg N, Hochreiter R, Zoihsl O, Fritzer A, Bezay N, Klingler A, Lingnau K, Schneider M, Lundberg U, Meinke A, Larcher-Senn J, Corbic-Ramljak I, Eder-Lingelbach S, Dubischar K, Bender W. Single-shot live-attenuated chikungunya vaccine in healthy adults: a phase 1, randomised controlled trial. Lancet Infect Dis. 2020 Oct;20(10):1193-1203. doi: 10.1016/S1473-3099(20)30238-3. Epub 2020 Jun 1.

Reference Type: DERIVED

PMID: 32497524 (View on PubMed)

Other Identifiers

VLA1553-101

Identifier Type: -

Identifier Source: org_study_id