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Dietary Antioxidants and Chronic Diseases-The Swedish National March Cohort

NCT ID: NCT03350568

Last Updated: 2017-11-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

43880 participants

Study Classification

OBSERVATIONAL

Study Start Date

1997-10-01

Study Completion Date

2010-12-31

Brief Summary

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Dietary antioxidants might protect from the development of chronic diseases by reducing levels of oxidative stress. The investigators therefore investigated the effect of dietary Non Enzymatic Antioxidant Capacity, which measures interactions between antioxidants in the whole diet, on the risk of 1) myocardial infarction and 2) osteoarthritis.

Detailed Description

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Aim: Among an initial sample of 43,880 men and women who participated in the Swedish National March Cohort in 1997 the investigators aimed to investigate the effect of dietary Non Enzymatic Antioxidant Capacity (NEAC), assessed by a validated food frequency questionnaire at baseline, on the risk of 1) myocardial infarction and 2) osteoarthritis.

Identification of cases: Incident cases of myocardial infarction (ICD-10 code I21) and osteoarthritis (ICD-10 M15-19) were identified through exact linkages to the Swedish registries of population, migration, death, cancer, and inpatient care, using the national registration numbers as identifiers.

Main methods: The investigators fitted Cox proportional hazards regression models with age as underlying time scale to estimate hazard ratios (HR) with 95% confidence intervals (95% CI) for each outcome of interest at different levels of dietary NEAC. The investigators fitted multiple imputation models based on chained equations to address missingness of confounder variables.

Conditions

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Myocardial Infarction Diet Osteoarthritis

Keywords

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Antioxidants Oxidative Stress Atherosclerosis Epidemiology

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Total dietary NEAC assessed at baseline

Intervention Type OTHER

Eligibility Criteria

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Exclusion Criteria

* Incorrect national registration number
* Subjects who were \<18 years
* Emigration before beginning of follow-up
* Death before beginning of follow-up
* Cancer diagnosis
* Any cardiovascular disease
* Extreme energy intake


* Incorrect national registration number
* Subjects who were \<40 years
* Emigration before beginning of follow-up
* Death before beginning of follow-up
* Osteoarthritis diagnosis
* Bone cancer- or metastases
* Joint injury or any arthropathy disease other than osteoarthritis
* Extreme energy intake
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Karolinska Institutet

OTHER

Sponsor Role lead

Responsible Party

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Ylva Trolle Lagerros

MD, Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ylva Trolle Lagerros, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Medicine, Clinical Epidemiology, Karolinska Institutet; Department of Medicine, Clinic of Endocrinology, Karolinska University Hospital

Locations

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Karolinska Institutet

Stockholm, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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97-205

Identifier Type: -

Identifier Source: org_study_id