Metronom Continuous Glucose Monitoring System

NCT ID: NCT03341026

Last Updated: 2019-08-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-06-30

Study Completion Date

2020-08-31

Brief Summary

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The aim of the present study is to investigate the clinical performance of the Metronom CGM system in patients with type 1 diabetes over a period of 14 days. In this study, the CGM sensor will be tested in an inpatient setting (meal/insulin test with frequent plasma glucose monitoring) at different days of wear-time. Sensor data will be compared to gold standard reference (Super GL2 analyser or YSI) and stability of sensor performance will be assessed over time. Additionally, safety and tolerability of the sensor will be investigated by regular assessment of the insertion site.

Detailed Description

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Conditions

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Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabete Mellitus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Induction day 1, 4, 7, 14

Patient will come to the hospital on day 1, 4, 7 and 14. A hypo- or hyperglycaemic experiment will start according to allocation by randomizer.

Group Type OTHER

Metronom CGM device

Intervention Type OTHER

Patient receives three Metronom CGM devices on day 1. On day 1, 4, 7 and 14, a hypo- or hyperglycaemic experiment will start according to allocation by randomizer.

Induction day 1, 7, 10, 14

Patient will come to the hospital on day 1, 7, 10 and 14. A hypo- or hyperglycaemic experiment will start according to allocation by randomizer.

Group Type OTHER

Metronom CGM device

Intervention Type OTHER

Patient receives three Metronom CGM devices on day 1. On day 1, 7, 10 and 14, a hypo- or hyperglycaemic experiment will start according to allocation by randomizer.

Interventions

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Metronom CGM device

Patient receives three Metronom CGM devices on day 1. On day 1, 4, 7 and 14, a hypo- or hyperglycaemic experiment will start according to allocation by randomizer.

Intervention Type OTHER

Metronom CGM device

Patient receives three Metronom CGM devices on day 1. On day 1, 7, 10 and 14, a hypo- or hyperglycaemic experiment will start according to allocation by randomizer.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Informed consent obtained after being advised of the nature of the study
* Male or female aged ≥18 years
* Type 1 diabetes for at least 6 months according to the WHO definition treated with multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII) for at least 3 months (for T1D only)
* Body Mass Index (BMI) \<35 kg/m²
* Flash or continuous glucose monitoring (FGM, CGM) user
* Willing and able to wear the Metronom CGM System for the duration of the study and undergo all study procedures
* HbA1c ≤86 mmol/mol

Exclusion Criteria

* Any disease or condition which the investigator or treating physician feels would interfere with the trial or the safety of the subject
* Female of childbearing potential who is pregnant, breast-feeding or intend to become pregnant or is not using adequate contraceptive methods
* Any mental condition rendering the subject incapable of giving his consent
* Subject is using any medication that significantly impacts glucose metabolism (oral steroids) except if stable for at least the last three months and expected to remain stable for the study duration
* Has severe medical or psychological condition(s) or chronic conditions/infections that in the opinion of the Investigator would compromise the subject's safety or successful participation in the study
* Subject is actively enrolled in another clinical trial
* Known adrenal gland problem, pancreatic tumour, or insulinoma
* Known bleeding disorder
* Known hypersensitivity to adhesive or skin lesions that hinder sensor insertion
* Inability of the subject to comply with all study procedures
* Inability of the subject to understand the subject information
* Subject donated blood in the last 3 months
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medical University of Graz

OTHER

Sponsor Role collaborator

Metronom Health

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Julia Mader, Ass Prof

Role: PRINCIPAL_INVESTIGATOR

Medical University of Graz

Locations

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Medical University of Graz

Graz, , Austria

Site Status

Steno diabetes center

Copenhagen, , Denmark

Site Status

Countries

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Austria Denmark

Central Contacts

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Ursula Morjaria, MSc

Role: CONTACT

0032(0)10 23 38 80

Joris Coteur, MSc

Role: CONTACT

0032(0)10 23 38 80

Facility Contacts

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Julia Mader, Ass. Prof.

Role: primary

Kirsten Norgaard, Ass. Prof.

Role: primary

Other Identifiers

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ELITE02

Identifier Type: -

Identifier Source: org_study_id

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