Pilot Prospective CGM Quality Improvement (QI) Project in Pregnancy

NCT ID: NCT02556554

Last Updated: 2020-07-21

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

67 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-08-31

Study Completion Date

2017-08-31

Brief Summary

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A single-center, prospective, 'open-label,' investigator-initiated pilot study evaluating the role of continuous glucose monitor (CGM) use either alone or with remote monitoring capabilities during pregnancy associated with T1DM.

Detailed Description

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A single-center, prospective, 'open-label,' investigator-initiated pilot study evaluating the role of continuous glucose monitor (CGM) use either alone or with remote monitoring capabilities that enable subjects to share CGM data with family and friends (whom the investigators will call "followers" in this protocol) among women with T1DM associated with pregnancy.

Conditions

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Diabetes Mellitus, Type I

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Routine Care

Standard of Care in the Pregnancy and Women's Health clinic.

Group Type NO_INTERVENTION

No interventions assigned to this group

Dexcom G4 Platinum CGM system

An intervention arm using the Dexcom G4 or G5 Platinum® CGM system during pregnancy.

Group Type ACTIVE_COMPARATOR

Dexcom G4 or G5 Platinum CGM system

Intervention Type DEVICE

Intervention arm using the Dexcom G4 or G5 Platinum® CGM system during pregnancy

Dexcom G4 Platinum CGM system with Share™

A treatment arm using the Dexcom G4 or G5 Platinum® CGM system with Share™ remote monitoring capabilities during pregnancy.

Group Type ACTIVE_COMPARATOR

Dexcom G4 or G5 Platinum CGM system with Share

Intervention Type DEVICE

Treatment arm using the Dexcom G4 or G5 Platinum® CGM system with Share™

Interventions

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Dexcom G4 or G5 Platinum CGM system

Intervention arm using the Dexcom G4 or G5 Platinum® CGM system during pregnancy

Intervention Type DEVICE

Dexcom G4 or G5 Platinum CGM system with Share

Treatment arm using the Dexcom G4 or G5 Platinum® CGM system with Share™

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Signed informed consent before any study-related activities
* Female aged 18 years and older
* T1D duration \>1 year
* Pregnancy with confirmation of gestational age 13 weeks or less
* Willingness to routinely practice at least 3-7 blood glucose measurements per day
* Using MDI or CSII therapy
* Willingness to provide an A1C level
* Ability and willingness to adhere to the protocol including scheduled study visits for the duration of the pregnancy
* Able to speak, read, and write English

Exclusion Criteria

* Extensive skin changes/diseases that inhibit wearing a sensor on normal skin
* Known allergy to adhesives
* Any other condition, as determined by the investigator, which could make the subject unsuitable for the trial, impairs the subject's suitability for the trial, or impairs the validity of the informed consent
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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DexCom, Inc.

INDUSTRY

Sponsor Role collaborator

University of Colorado, Denver

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sarit Polsky, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

University of Colorado, Denver

Locations

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University of Colorado

Aurora, Colorado, United States

Site Status

Countries

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United States

References

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Shah VN, Snell-Bergeon JK, Demmitt JK, Joshee P, Garcetti R, Pyle L, Polsky S. Relationship Between Time-in-Range, HbA1c, and the Glucose Management Indicator in Pregnancies Complicated by Type 1 Diabetes. Diabetes Technol Ther. 2021 Dec;23(12):783-790. doi: 10.1089/dia.2021.0093. Epub 2021 Nov 3.

Reference Type DERIVED
PMID: 34524020 (View on PubMed)

Buschur EO, Campbell K, Pyle L, Garcetti R, Joshee P, Demmitt JK, Snell-Bergeon JK, Polsky S. Exploratory Analysis of Glycemic Control and Variability Over Gestation Among Pregnant Women with Type 1 Diabetes. Diabetes Technol Ther. 2021 Nov;23(11):768-772. doi: 10.1089/dia.2021.0138.

Reference Type DERIVED
PMID: 34115946 (View on PubMed)

Polsky S, Garcetti R, Pyle L, Joshee P, Demmitt JK, Snell-Bergeon JK. Continuous Glucose Monitor Use With Remote Monitoring Reduces Fear of Hypoglycemia in Pregnant Women With Type 1 Diabetes: A Pilot Study. J Diabetes Sci Technol. 2020 Jan;14(1):191-192. doi: 10.1177/1932296819890864. Epub 2019 Nov 28. No abstract available.

Reference Type DERIVED
PMID: 31779476 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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15-1006

Identifier Type: -

Identifier Source: org_study_id

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