Duration of Doxycycline Treatment in MEM Patients

NCT ID: NCT03337932

Last Updated: 2025-03-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-01

Study Completion Date

2027-12-31

Brief Summary

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The purpose of this study is to compare the efficacy of 7-day versus 14-day doxycycline treatment in patients with multiple erythema migrans.

Detailed Description

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Conditions

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Erythema Chronicum Migrans

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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MEM-7 days doxycycline

Group Type ACTIVE_COMPARATOR

Doxycycline 100 milligram Oral Tablet bid, 7 days

Intervention Type DRUG

Patients will receive doxycycline for 7 days.

MEM-14 days doxycycline

Group Type ACTIVE_COMPARATOR

Doxycycline 100 milligram Oral Tablet bid, 14 days

Intervention Type DRUG

Patients will receive doxycycline for 14 days.

Controls

Group Type PLACEBO_COMPARATOR

Controls without a history of lyme disease.

Intervention Type DRUG

No intervention.

Interventions

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Doxycycline 100 milligram Oral Tablet bid, 7 days

Patients will receive doxycycline for 7 days.

Intervention Type DRUG

Doxycycline 100 milligram Oral Tablet bid, 14 days

Patients will receive doxycycline for 14 days.

Intervention Type DRUG

Controls without a history of lyme disease.

No intervention.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

• multiple erythema migrans

Exclusion Criteria

* pregnancy or lactation
* immunocompromised
* serious adverse event to doxycycline
* taking antibiotic with antiborrelial activity within 10 days
* extracutaneous manifestations of lyme borreliosis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Medical Centre Ljubljana

OTHER

Sponsor Role lead

Responsible Party

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Daša Stupica

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Daša Stupica, MD PhD

Role: PRINCIPAL_INVESTIGATOR

University Medical Centre Ljubljana

Locations

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University Medical center Ljubljana

Ljubljana, , Slovenia

Site Status RECRUITING

Countries

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Slovenia

Central Contacts

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Daša Stupica, MD, PhD

Role: CONTACT

+386 31 689 324

Maša Velušček, MD

Role: CONTACT

+386 1 522 21 10

Facility Contacts

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Daša Stupica, MD, PhD

Role: primary

+386 31 689 324

Maša Velušček, MD

Role: backup

+386 1 522 21 10

Other Identifiers

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MEM-Doxy

Identifier Type: -

Identifier Source: org_study_id

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