Study of the Reaction of the Brain to Various Stimulations

NCT ID: NCT03334526

Last Updated: 2023-02-16

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 174 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-11-09
• Study Completion Date: 2022-06-24

Brief Summary

Physical activity is considered a therapeutic strategy in its own right in a vast majority of disabling chronic disorders. It leads to an increase in physical and probably cognitive capacity, thanks to its effects on both metabolism (muscle hypertrophy, improvement in oxidative metabolism) and the nervous system (neuroplasticity). Nonetheless, even though there is a consensus on the positive effects of physical exercise (PE) on cerebral plasticity, the physiological mechanisms by which PE affects neuroplasticity, in particular depending on the mode of muscle contraction, are still hypothetical. Moreover, several recent studies have shown that mental learning (ML) by motor imagery improves motor performance, thus making it of interest in a context of rehabilitation, in particular in situations where PE is transient of definitively impossible. Yet, the mechanisms and brain structures involved in motor learning by ML have not been established so far. Finally, on the basis of clinical observations concerning the key role of sensory input in motor function, the hypothesis that increased demand on this input by electrical stimulation (ES) as a means to improve motor function has been proposed. However, the mechanisms by which this type of stimulation could induce neuroplasticity is still to be elucidated.

Conditions

Corticospinal Plasticity; Neuromuscular Plasticity

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

healthy volunteers

Group Type: EXPERIMENTAL

physical training

Intervention Type: OTHER

workout on treadmill requiring the muscles of the lower limbs mostly in concentric (ascent) or eccentric (downhill)

mental training

Intervention Type: OTHER

The task to imagine for the training group will be an abduction of the thumb

electrical stimulation

Intervention Type: OTHER

electrical stimulation of the muscles

Interventions

physical training

workout on treadmill requiring the muscles of the lower limbs mostly in concentric (ascent) or eccentric (downhill)

Intervention Type: OTHER

mental training

The task to imagine for the training group will be an abduction of the thumb

Intervention Type: OTHER

electrical stimulation

electrical stimulation of the muscles

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• persons who have provided written consent
• healthy subjects
• national health insurance cover
• age 18 to 60 years

Exclusion Criteria

• personal or family history of epilepsy
• pacemakers or other apparatus likely to interfere with the magnetic field
• history of psychiatric disease
• Persons under guardianship or wards of court
• Pregnant or breast-feeding women
• problem perceived during the neurological examination which could bias the results of the study

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Centre Hospitalier Universitaire Dijon

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

CHU Dijon Bourgogne

Dijon, , France

Countries

France

References

Dupont W, Papaxanthis C, Lebon F, Madden-Lombardi C. Mental Simulations and Action Language Are Impaired in Individuals with Aphantasia. J Cogn Neurosci. 2024 Feb 1;36(2):261-271. doi: 10.1162/jocn_a_02084.

Reference Type: DERIVED

PMID: 37944123 (View on PubMed)

Other Identifiers

GREMEAUX 2017

Identifier Type: -

Identifier Source: org_study_id