Trial Outcomes & Findings for Investigating the Neural Correlates in Memory Retrieval After HD-tDCS (NCT NCT03319134)

NCT ID: NCT03319134

Last Updated: 2020-08-26

Results Overview

Participants had to learn an association between a face and a name. The face-name association memory task was divided into (1) an encoding phase, (2) a consolidation phase, and (3) a retrieval phase. During the encoding phase, participants studied 60 successively presented face-name pairs. Participants were instructed to assess the gender of each face shown to keep participants focused on the task. The encoding phase lasted approximately 5 minutes. This is followed by a consolidation phase where participants were instructed to "sit still, relax, and think about nothing in particular" for 10 minutes. During the retrieval phase, participants were presented with 60 old and 60 new faces and were instructed to assess whether they had seen this face during the encoding phase, or if it was a 'new' face. Participants received active or sham transcranial direct current stimulation targetting the posterior cingulate cortex during retrieval. The outcome is correctly recalled old faces.

Recruitment status

COMPLETED

Study phase

Target enrollment

45 participants

Primary outcome timeframe

Retrieval Memory is assessed after 90 seconds break following the recognition phase.

Results posted on

2020-08-26

Participant Flow

Participant milestones

Participant milestones
Measure	Active Anodal HD-tDCS Active anodal HD-tDCS stimulation applied during memory task	Sham HD-tDCS Sham HD-tDCS stimulation during memory task for comparison	Active Cathodal HD-tDCS Active cathodal HD-tDCS stimulation applied during memory task
Overall Study STARTED	15	15	15
Overall Study COMPLETED	15	15	15
Overall Study NOT COMPLETED	0	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Investigating the Neural Correlates in Memory Retrieval After HD-tDCS

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Active Anodal HD-tDCS n=15 Participants Active anodal HD-tDCS stimulation applied during memory task	Sham HD-tDCS n=15 Participants Sham HD-tDCS stimulation during memory task for comparison	Active Cathodal HD-tDCS n=15 Participants Active cathodal HD-tDCS stimulation applied during memory task	Total n=45 Participants Total of all reporting groups
Age, Categorical <=18 years	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants
Age, Categorical Between 18 and 65 years	15 Participants n=5 Participants	15 Participants n=7 Participants	15 Participants n=5 Participants	45 Participants n=4 Participants
Age, Categorical >=65 years	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants
Age, Continuous	18.8 years STANDARD_DEVIATION 1.78 • n=5 Participants	18.8 years STANDARD_DEVIATION 1.32 • n=7 Participants	18.9 years STANDARD_DEVIATION 1.53 • n=5 Participants	18.84 years STANDARD_DEVIATION 1.52 • n=4 Participants
Sex: Female, Male Female	10 Participants n=5 Participants	12 Participants n=7 Participants	11 Participants n=5 Participants	33 Participants n=4 Participants
Sex: Female, Male Male	5 Participants n=5 Participants	3 Participants n=7 Participants	4 Participants n=5 Participants	12 Participants n=4 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants	0 Participants n=4 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	15 Participants n=5 Participants	15 Participants n=7 Participants	15 Participants n=5 Participants	45 Participants n=4 Participants
Region of Enrollment United States	15 participants n=5 Participants	15 participants n=7 Participants	15 participants n=5 Participants	45 participants n=4 Participants

PRIMARY outcome

Timeframe: Retrieval Memory is assessed after 90 seconds break following the recognition phase.

Outcome measures

Outcome measures
Measure	Active Anodal HD-tDCS n=15 Participants Active anodal HD-tDCS stimulation applied during memory task	Sham HD-tDCS n=15 Participants Sham HD-tDCS stimulation during memory task for comparison	Active Cathodal HD-tDCS n=15 Participants Active cathodal HD-tDCS stimulation applied during memory task
Recognition Memory Assessed by a Retrieval Memory Experiment	48.47 percentage of correctly recalled old fac Standard Error 4.038	34.78 percentage of correctly recalled old fac Standard Error 4.038	33.983 percentage of correctly recalled old fac Standard Error 4.662

Adverse Events

Active Anodal HD-tDCS

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Sham HD-tDCS

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Active Cathodal HD-tDCS

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Clinical Trial Manager

UT Dallas

Phone: 9723337277

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place