Pediatric Ease of Use ELLIPTA Items

NCT ID: NCT03315572

Last Updated: 2019-01-28

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

28 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-10-17

Study Completion Date

2017-12-01

Brief Summary

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A range of devices has been developed to administer inhaled therapy for asthma, including dry powder inhaler (DPI) devices. ELLIPTA is a DPI that is preloaded with a drug therapy to treat asthmatic subjects. The objective of this study is to revise ease of use items developed for adults to be appropriate for completion by pediatric subjects in future clinical trials and to evaluate the newly developed items in subjects with asthma aged 5 to 11 years and their caregivers. This is a cross-sectional, qualitative study that will involve pediatric subjects with asthma who are currently using an asthma maintenance inhaler and their caregivers. Two rounds of repetitive cognitive interviews will be conducted with 16 subjects in each interview set. Each interview will last approximately 45 minutes. Data provided by pediatric subjects and their caregivers during interview will be collected as field notes and audio recordings which will be transcribed.

Detailed Description

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Conditions

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Asthma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Pediatric subject/caregiver dyads-first interview set

The first interview set will consist of eight pediatric subject/caregiver dyads including pediatric subjects with asthma currently using a maintenance inhaler and his or her caregiver. The pediatric subjects and their caregivers will be asked questions regarding ease of use of ELLIPTA inhaler.

Interviewer administered version of ease of use items

Intervention Type OTHER

The adult ease of use items will be modified to incorporate language appropriate for pediatric subjects. The interview will be administered by trained clinic-staff for subjects aged 5 to 7 years and those aged 8 to 11 years having difficulty in reading.

Self-administered version of ease of use items

Intervention Type OTHER

The interview will be self-administered by subjects aged 8 to 11 years.

Caregiver version of ease of use items

Intervention Type OTHER

Caregivers will be asked questions regarding their observations and experiences while their child was using ELLIPTA inhaler.

Pediatric subject/caregiver dyads-second interview set

The second interview set will consist of eight pediatric subject/caregiver dyads including pediatric subjects with asthma currently using a maintenance inhaler and his or her caregiver. The pediatric subjects and their caregivers will be asked questions regarding ease of use of ELLIPTA inhaler.

Interviewer administered version of ease of use items

Intervention Type OTHER

The adult ease of use items will be modified to incorporate language appropriate for pediatric subjects. The interview will be administered by trained clinic-staff for subjects aged 5 to 7 years and those aged 8 to 11 years having difficulty in reading.

Self-administered version of ease of use items

Intervention Type OTHER

The interview will be self-administered by subjects aged 8 to 11 years.

Caregiver version of ease of use items

Intervention Type OTHER

Caregivers will be asked questions regarding their observations and experiences while their child was using ELLIPTA inhaler.

Interventions

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Interviewer administered version of ease of use items

The adult ease of use items will be modified to incorporate language appropriate for pediatric subjects. The interview will be administered by trained clinic-staff for subjects aged 5 to 7 years and those aged 8 to 11 years having difficulty in reading.

Intervention Type OTHER

Self-administered version of ease of use items

The interview will be self-administered by subjects aged 8 to 11 years.

Intervention Type OTHER

Caregiver version of ease of use items

Caregivers will be asked questions regarding their observations and experiences while their child was using ELLIPTA inhaler.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Be 5 to 11 years of age
* Have asthma
* Currently use a maintenance inhaler to treat their asthma
* Be willing and able to provide assent
* Above 18+ years of age
* Be a caregiver (parent or legal guardian) of a pediatric subject with asthma that meets the criteria above
* Be willing and able to provide signed and dated informed consent and parental permission in English
* Be willing and able to participate in a 45-minute interview

Exclusion Criteria

* Nil
Minimum Eligible Age

5 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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RTI Health Solutions(RTI HS)

UNKNOWN

Sponsor Role collaborator

GlaxoSmithKline

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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GSK Clinical Trials

Role: STUDY_DIRECTOR

GlaxoSmithKline

Locations

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GSK Investigational Site

Southfield, Michigan, United States

Site Status

GSK Investigational Site

Raleigh, North Carolina, United States

Site Status

Countries

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United States

References

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Halverson P, Liem J, Heyes L, Preece A, Bareille P, Rees J, Jain R, Stanford RH, Lenney W, Collison K, Sharma R. The evaluation of the correct use and ease-of use of the ELLIPTA DPI in children with asthma. Pediatr Pulmonol. 2021 Jan;56(1):57-64. doi: 10.1002/ppul.25149. Epub 2020 Nov 19.

Reference Type DERIVED
PMID: 33124762 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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HO-17-18594

Identifier Type: OTHER

Identifier Source: secondary_id

208129

Identifier Type: -

Identifier Source: org_study_id

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