House Dust Mite Induced Inflammasome Activation on Corticosteroid Resistance

NCT ID: NCT03307278

Last Updated: 2021-08-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2017-11-30

Study Completion Date

2018-09-06

Brief Summary

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In this project, PBMCs will be isolated from HDM allergic and non allergic patient and then stimulated with HDM crude extract. The expression of inflammasome and the correlation of inflammasome activation and steroid resistance will be investigated.

Detailed Description

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Conditions

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Allergic Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Steroid resistance in HDM allergic patients

Group Type EXPERIMENTAL

House dust mite

Intervention Type BIOLOGICAL

As a stimulant to induce inflammasome activation

Steroid resistance in non HDM allergic subjects

Group Type EXPERIMENTAL

House dust mite

Intervention Type BIOLOGICAL

As a stimulant to induce inflammasome activation

Interventions

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House dust mite

As a stimulant to induce inflammasome activation

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* HDM allergic and non allergic subjects

Exclusion Criteria

* Pregnant subject, cancer
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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China Medical University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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CMUH106-REC3-115

Identifier Type: -

Identifier Source: org_study_id

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