A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis 01

NCT ID: NCT03285308

Last Updated: 2021-07-29

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

336 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-09-29

Study Completion Date

2020-07-08

Brief Summary

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This study will evaluate the safety and efficacy of relamorelin compared to placebo in participants with diabetic gastroparesis. Participants will report daily severity scores of their diabetic gastroparesis symptoms.

Detailed Description

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Conditions

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Gastroparesis Diabetes Mellitus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Placebo

Following a 2-week placebo run-in, participants received placebo-matching relamorelin injected subcutaneously twice daily for up to 12 weeks.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo injected subcutaneously twice daily.

Relamorelin 10 μg

Following a 2-week placebo run-in, participants received relamorelin 10 μg injected subcutaneously twice daily for up to 12 weeks.

Group Type EXPERIMENTAL

Relamorelin

Intervention Type DRUG

Relamorelin 10 micrograms (μg) injected subcutaneously twice daily.

Interventions

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Placebo

Placebo injected subcutaneously twice daily.

Intervention Type DRUG

Relamorelin

Relamorelin 10 micrograms (μg) injected subcutaneously twice daily.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of Type 1 or Type 2 diabetes mellitus
* Meet the per protocol criteria of diabetic gastroparesis
* Compliance with diary
* Compliance with the per protocol study treatment dosing instructions

Exclusion Criteria

* Currently receiving nutrition intravenously, by nasogastric tube, or other feeding tube
* Actively experiencing anorexia nervosa, binge-eating, bulimia, or other eating disorder at the time of Screening (Visit 1)
* Diagnosis of Celiac Disease, also a history of non-celiac gluten sensitivity
* History of gastrointestinal disorders that may be similar to gastroparesis
* Functional dyspepsia diagnosed before the diagnosis of diabetes mellitus
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Allergan

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wieslaw (Wes) Bochenek, MD, PhD

Role: STUDY_DIRECTOR

Allergan

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

Digestive Health Specialist of the South East

Dothan, Alabama, United States

Site Status

Avant Research Associates

Huntsville, Alabama, United States

Site Status

Synexus Clinical Research US, Inc.

Fountain Hills, Arizona, United States

Site Status

Central Arizona Medical Associates

Mesa, Arizona, United States

Site Status

Phoenix Clinical LLC

Phoenix, Arizona, United States

Site Status

Del Sol Research Management, LLC

Tucson, Arizona, United States

Site Status

Preferred Research Partners, Inc.

Little Rock, Arkansas, United States

Site Status

Arkansas Gastorenterology

North Little Rock, Arkansas, United States

Site Status

Hope Clinical Research

Canoga Park, California, United States

Site Status

Kindred Medical Institute for Clinical Trials, LLC

Corona, California, United States

Site Status

Aurora Care Clinic, LLC

Costa Mesa, California, United States

Site Status

Citrus Valley Gastroenterology Clinic

Covina, California, United States

Site Status

VVCRD Research

Garden Grove, California, United States

Site Status

University of California San Diego

La Jolla, California, United States

Site Status

Om Research LLC

Lancaster, California, United States

Site Status

Clinical Applications Laboratories, Inc.

San Diego, California, United States

Site Status

Medical Associates Research Group, Inc

San Diego, California, United States

Site Status

Synexus Clinical Research, US, Santa Rosa

Santa Rosa, California, United States

Site Status

Upland Clinical Research

Upland, California, United States

Site Status

Synexus Clinical Research US, Inc.

Vista, California, United States

Site Status

University of Colorado, Denver

Aurora, Colorado, United States

Site Status

Peak Gastroenterology Associates

Colorado Springs, Colorado, United States

Site Status

Denver Esophageal and Stomach Center

Englewood, Colorado, United States

Site Status

Connecticut Clinical Research Foundation

Bristol, Connecticut, United States

Site Status

Medical Research Center of Connecticut, LLC

Hamden, Connecticut, United States

Site Status

TrialSpark, Inc.

Washington D.C., District of Columbia, United States

Site Status

Innovative Research of West FL, Inc.

Clearwater, Florida, United States

Site Status

West Central Gastroenterology

Clearwater, Florida, United States

Site Status

American Research Institute, Inc

Cutler Bay, Florida, United States

Site Status

Top Medical Research

Cutler Bay, Florida, United States

Site Status

Nature Coast Clinical Research

Inverness, Florida, United States

Site Status

Cfagi Llc

Maitland, Florida, United States

Site Status

APF Research LLC

Miami, Florida, United States

Site Status

AMPM Research Clinic

Miami, Florida, United States

Site Status

Advanced Medical Research Institute

Miami, Florida, United States

Site Status

Florida Research Center, Inc.

Miami, Florida, United States

Site Status

Savin Medical Group LLC

Miami Lakes, Florida, United States

Site Status

Sensible Healthcare

Ocoee, Florida, United States

Site Status

Gulf Region Clinical Research Institute

Pensacola, Florida, United States

Site Status

University of South Florida

Tampa, Florida, United States

Site Status

West Central Gastroenterology

Tampa, Florida, United States

Site Status

Summit Clinical Research, LLC

Carnesville, Georgia, United States

Site Status

Infinite Clinical Trials

Riverdale, Georgia, United States

Site Status

Southwest Gastroenterology

Oak Lawn, Illinois, United States

Site Status

MediSphere Medical Research Center, LLC

Evansville, Indiana, United States

Site Status

Synexus Clinical Research US, Inc.

Evansville, Indiana, United States

Site Status

Indiana University Health University Hospital

Indianapolis, Indiana, United States

Site Status

University of Iowa Hospitals and Clinics

Iowa City, Iowa, United States

Site Status

University of Kansas Medical Center

Kansas City, Kansas, United States

Site Status

Cotton-O'Neil Clinical Research Center - Digestive Health

Topeka, Kansas, United States

Site Status

University of Louisville

Louisville, Kentucky, United States

Site Status

Delta Research Partners

Bastrop, Louisiana, United States

Site Status

Cronola LLC

Houma, Louisiana, United States

Site Status

New Orleans Research Institute - Metropolitan Gastroenterology Associates

Metairie, Louisiana, United States

Site Status

Gastro Center of Maryland

Columbia, Maryland, United States

Site Status

Frederick Gastroenterology Associates, PA an Elligo Health Research Site

Frederick, Maryland, United States

Site Status

Boston VA Healthcare System

West Roxbury, Massachusetts, United States

Site Status

Vida Clinical Studies

Dearborn, Michigan, United States

Site Status

National Clinical, LLC

Hamtramck, Michigan, United States

Site Status

Henry Ford Health System

Novi, Michigan, United States

Site Status

Gastroenterology Associates of Western Michigan

Wyoming, Michigan, United States

Site Status

MNGI Digestive Health

Coon Rapids, Minnesota, United States

Site Status

Synexus Clinical Research US, Inc.

Richfield, Minnesota, United States

Site Status

Montana Medical Research

Missoula, Montana, United States

Site Status

Synexus Clinical Research

Henderson, Nevada, United States

Site Status

Excel Clinical Research

Las Vegas, Nevada, United States

Site Status

Clinical Research of South Nevada

Las Vegas, Nevada, United States

Site Status

Advanced Biomedical Research of America

Las Vegas, Nevada, United States

Site Status

Digestive Disease Specialists

Las Vegas, Nevada, United States

Site Status

Palm Research Center

Las Vegas, Nevada, United States

Site Status

Garden State Endocrinology

Brick, New Jersey, United States

Site Status

Synexus Clinical Research US, Inc.

Bridgeton, New Jersey, United States

Site Status

AGA Clinical Research Associates LLC

Egg Harbor, New Jersey, United States

Site Status

Long Island Gastrointestinal Research Group LLP

Great Neck, New York, United States

Site Status

United Health Services Hospitals, Inc.

Johnson City, New York, United States

Site Status

CHEAR Center, LLC

The Bronx, New York, United States

Site Status

Asheville Gastroenterology Associates

Asheville, North Carolina, United States

Site Status

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, United States

Site Status

Carolinas Healthcare-Charlotte

Charlotte, North Carolina, United States

Site Status

Carolina Digestive Health Associates

Concord, North Carolina, United States

Site Status

Cumberland Research Associates, LLC

Fayetteville, North Carolina, United States

Site Status

Triad Clinical Trials

Greensboro, North Carolina, United States

Site Status

PMG Research Salisbury

Salisbury, North Carolina, United States

Site Status

The Center for Clinical Research

Winston-Salem, North Carolina, United States

Site Status

Dayton Gastroenterology,Inc.

Beavercreek, Ohio, United States

Site Status

Endocrinology Research Associates, Inc.

Columbus, Ohio, United States

Site Status

Hometown Urgent Care and Research

Columbus, Ohio, United States

Site Status

Premier Clinical Research d.b.a. STAT Research

Franklin, Ohio, United States

Site Status

Family Practice Center of Wadsworth, Inc.

Wadsworth, Ohio, United States

Site Status

Digestive Disease Specialists Inc

Oklahoma City, Oklahoma, United States

Site Status

Memorial Clinical Research

Oklahoma City, Oklahoma, United States

Site Status

Northwest Gastroenterology Clinic, LLC

Portland, Oregon, United States

Site Status

Family Medical Associates, Research Department

Levittown, Pennsylvania, United States

Site Status

Preferred Primary Care Physicians, Inc.

Pittsburgh, Pennsylvania, United States

Site Status

Montgomery Medical, Inc.

Smithfield, Pennsylvania, United States

Site Status

Synexus Clinical Research US, Inc.

Anderson, South Carolina, United States

Site Status

Carolina Medical Research

Clinton, South Carolina, United States

Site Status

Gastroenterology Associates, PA

Greenville, South Carolina, United States

Site Status

Synexus Clinical Research

Greer, South Carolina, United States

Site Status

Quality Medical Research

Nashville, Tennessee, United States

Site Status

Avant Research Associates,LLC

Austin, Texas, United States

Site Status

Synexus Clinical Research US, Inc.

Dallas, Texas, United States

Site Status

Amir Ali Hassan, MD, PA

Houston, Texas, United States

Site Status

Clinical Trials of Texas, Inc.

San Antonio, Texas, United States

Site Status

Sagact Pllc

San Antonio, Texas, United States

Site Status

Synexus Clinical Research US, Inc.

Layton, Utah, United States

Site Status

Synexus Clinical Research US, Inc.

Murray, Utah, United States

Site Status

Advanced Research Institute, Inc.

Ogden, Utah, United States

Site Status

Advanced Clinical Research

West Jordan, Utah, United States

Site Status

Verity Research Inc.

Fairfax, Virginia, United States

Site Status

Cardinal Internal Medicine

Woodbridge, Virginia, United States

Site Status

West Virginia University

Morgantown, West Virginia, United States

Site Status

Nepean Hospital

Kingswood, New South Wales, Australia

Site Status

Royal Adelaide Hospital - Central Adelaide Local Health Network Incorporated

Adelaide, South Australia, Australia

Site Status

The Alfred Hospital

Melbourne, Victoria, Australia

Site Status

Royal Melbourne Hospital

Parkville, Victoria, Australia

Site Status

MHAT Yuliya Vrevska Byala

Byala, Ruse, Bulgaria

Site Status

UMHAT - Kaspela- EOOD

Plovdiv, , Bulgaria

Site Status

Medical Center Asklepion - Humane Medicine Research EOOD

Sofia, , Bulgaria

Site Status

Alexandrovska University Hospital

Sofia, , Bulgaria

Site Status

CHU Nantes

Nantes, , France

Site Status

Hopital Charles Nicolle

Rouen, , France

Site Status

Kumudini Devi Diabetes Research Center; Ramdevrao Hospital

Hyderabad, Andhra Pradesh, India

Site Status

King George Hospital

Visakhapatnam, Andhra Pradesh, India

Site Status

Dr. Jivraj Mehta Smarak Health Foundation Bakeri Medical Research Centre - Gasterentrology

Ahmedabad, Gujarat, India

Site Status

Victoria Hospital

Bangalore, Karnataka, India

Site Status

Life Care Hospital & Research Centre

Bangalore, Karnataka, India

Site Status

Diacon Hospital and research Center - Diabetology

Bengaluru, Karnataka, India

Site Status

Rajalakshmi Hospital

Bengaluru, Karnataka, India

Site Status

Vinaya Hospital & Research Centre

Mangalore, Karnataka, India

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Bhatia Hospital

Mumbai, Maharashtra, India

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B. J. Government Medical College and Sassoon General Hospitals

Pune, Maharashtra, India

Site Status

Universal Hospital

Pune, Maharashtra, India

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Noble Hospital Pvt. Ltd

Pune, Maharashtra, India

Site Status

S R Kalla (SRK) Memorial Gastro & General Hospital

Jaipur, Rajasthan, India

Site Status

SMS Hospital

Jaipur, Rajasthan, India

Site Status

Diabetic Thyroid and Endocrine Centre

Jaipur, Rajasthan, India

Site Status

Marudhar Hospital

Jaipur, Rajasthan, India

Site Status

Eternal Hospital - Diabetology

Jaipur, Rajasthan, India

Site Status

M.V. Hospital for Diabetes & Diabetes Research Centre

Chennai, Tamil Nadu, India

Site Status

Kovai Diabetes Speciality Centre

Coimbatore, Tamil Nadu, India

Site Status

M V Hospital & Research Centre

Lucknow, Uttar Pradesh, India

Site Status

Arthur Asirvatham Hospital

Madurai, , India

Site Status

Sir Ganga Ram Hospital

New Delhi, , India

Site Status

Soroka University Medical Center

Beersheba, , Israel

Site Status

Bnai Zion Medical Center

Haifa, , Israel

Site Status

E. Wolfson Medical Center

Holon, , Israel

Site Status

Digestive Diseases Institute

Jerusalem, , Israel

Site Status

Gastroenterology Institute

Petah Tikva, , Israel

Site Status

Endocrinology & Diabetes Center

Safed, , Israel

Site Status

Gastroenterology Institute

Tel Aviv, , Israel

Site Status

Hospital Sultanah Bahiyah

Alor Star, Kedah, Malaysia

Site Status

University Malaya Medical Centre

Kuala Lumpur, , Malaysia

Site Status

Universiti Sains Malaysia

Kubang Kerian, , Malaysia

Site Status

Hospital Taiping

Taiping, , Malaysia

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Manila Doctors Hospital

Ermita, Manila, Philippines

Site Status

San Juan De Dios Educational Foundation, Inc.

Pasay, National Capital Region, Philippines

Site Status

Cardinal Santos Medical Center

San Juan City, National Capital Region, Philippines

Site Status

Ospital ng Makati

Makati City, NCR, Philippines

Site Status

Perpetual Succor Hospital

Cebu City, , Philippines

Site Status

West Visayas State University Medical Center

Iloilo City, , Philippines

Site Status

St. Luke's Medical Center

Quezon City, , Philippines

Site Status

Synexus Polska Sp.z o.o.

Pomorskie, Gdansk, Poland

Site Status

CenterMed Krakow Ltd

Krakow, Malopolska, Poland

Site Status

Centrum Medyczne Pratia S.A. Warsaw, Poland

Warsaw, Mazowian, Poland

Site Status

Endoskopia Sp. Z O.O.

Sopot, Pomeranian Voivodeship, Poland

Site Status

Synexus Polska Sp. z o.o.Oddzial w Poznaniu

Poznan, Poznañ, Poland

Site Status

Wojewodzki Szpital Specjalistyczny w Olsztynie

Olsztyn, Warmian-Masurian Voivodeship, Poland

Site Status

NZOZ Vita Diabetica - Malgorzata Buraczyk

Bialystok, , Poland

Site Status

Centrum Medyczne Lukamed

Chojnice, , Poland

Site Status

Synexus Polska sp.z.o.o oddzial Czestochowa

Częstochowa, , Poland

Site Status

Specjalistyczny Gabinet Neurologiczny Marta Banach

Krakow, , Poland

Site Status

Synexus Polska Sp. z o.o. Oddzial w Lodzi

Lodz, , Poland

Site Status

Sanitas Centrum Medyczne

Lublin, , Poland

Site Status

Synexus Polska Sp. z o.o. Oddzial w Warszawie

Warsaw, , Poland

Site Status

DRS Wroclaw

Wroclaw, , Poland

Site Status

Centrum Badan Klinicznych Piotr Napora Lekarze Spolka Partnerska

Wroclaw, , Poland

Site Status

National University Hospital

Singapore, , Singapore

Site Status

Changi General Hospital

Singapore, , Singapore

Site Status

Singapore General Hospital

Singapore, , Singapore

Site Status

Chonbuk National University Hospital

Jeonju, Jeollabuk-do, South Korea

Site Status

Sanggye Paik Hospital, Inje University College of Medicine

Seoul, Nowon-gu, South Korea

Site Status

Asan Medical Center

Seoul, , South Korea

Site Status

Hospital Universitario Principe de Asturias

Madrid, , Spain

Site Status

Hospital Universitario De Salamanca

Salamanca, , Spain

Site Status

Hospital Universitario Virgen del Rocío

Seville, , Spain

Site Status

Phramongkutklao Hospital

Bangkok, , Thailand

Site Status

Faculty of Medicine, Siriraj Hospital, Mahidol University

Bangkok, , Thailand

Site Status

Maharaj Nakorn Chiang Mai Hospital

Chiang Mai, , Thailand

Site Status

Communal Institution "Odesa Regional Clinical Hospital", Out-patient department

Odesa, Odesa Oblast, Ukraine

Site Status

Limited Liability Company "Medical Center "Salutem"

Vinnitsa, Vinnytsia Oblast, Ukraine

Site Status

Municipal Institution City Hospital No. 7

Zaporizhzhia, Zaporizhzhia Oblast, Ukraine

Site Status

Regional municipal institution "Chernivtsi's regional clinical hospital", gastroenterological department, Higher state educational establishment of Ukraine "Bukovinian state medical university", department of internal medicine and infectious diseases, c.C

Chernivtsi, , Ukraine

Site Status

Regional Public Organization Chernivtsi Regional Endocrinology Center

Chernivtsi, , Ukraine

Site Status

State Institution Ukrainian State Research Institute of Medical and Social Problems of Disability of the Ministry of Health of Ukraine

Dnipro, , Ukraine

Site Status

Ivano-Frankivsk National Medical University

Ivano-Frankivsk, , Ukraine

Site Status

Ivano-Frankivsk Central City Clinical Hospital

Ivano-Frankivsk, , Ukraine

Site Status

Municipal nonprofit entity of Kharkiv municipal council

Kharkiv, , Ukraine

Site Status

L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine

Kharkiv, , Ukraine

Site Status

Clinical Endocrinology of SI "V.Danilevsky Institute for endocrine pathology problems National Academy of Medical sciences of Ukraine"

Kharkiv, , Ukraine

Site Status

Communal Institution Kherson City Clinical Hospital

Kherson, , Ukraine

Site Status

Kyiv municipal clinical endocrinological center

Kyiv, , Ukraine

Site Status

AS Medbud Clinic

Kyiv, , Ukraine

Site Status

AS PVNZ

Kyiv, , Ukraine

Site Status

Limited Liability Company "Medical and Diagnostic Center "ADONIS Plus", outpatient department, c. Kyiv

Kyiv, , Ukraine

Site Status

Kyiv Railway hospital on the railway transport #2 of the branch "health

Kyiv, , Ukraine

Site Status

Medical Center Universal Clinic Oberig

Kyiv, , Ukraine

Site Status

Polyclinic of medical services and rehabilitation department of State Joint-Stock Holding Company Artem, day-patient unit

Kyiv, , Ukraine

Site Status

Odessa Railway Clinical Hospital of Branch of HC JSC Ukrzaliznytsia, Odessa National Medical University

Odesa, , Ukraine

Site Status

Poltava Regional Clinical Hospital

Poltava, , Ukraine

Site Status

Ternopil University Hospital

Ternopil, , Ukraine

Site Status

Private Small-Scale Enterprise Medical Centre Pulse

Vinnytsia, , Ukraine

Site Status

Vinnytsia Regional Clinical highly specialized Endocrinology Centre

Vinnytsia, , Ukraine

Site Status

Municipal nonprofit entity "Vinnytsia's city clinical hospital #1", c. Vinnytsia

Vinnytsia, , Ukraine

Site Status

6th City Clinical Hospital, c. Zaporizhzhia

Zaporizhzhia, , Ukraine

Site Status

Countries

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United States Australia Bulgaria France India Israel Malaysia Philippines Poland Singapore South Korea Spain Thailand Ukraine

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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2017-002136-16

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

RLM-MD-01

Identifier Type: -

Identifier Source: org_study_id

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