A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis Study 04

NCT ID: NCT03383146

Last Updated: 2021-11-23

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

450 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-01

Study Completion Date

2020-11-05

Brief Summary

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A 52-week study to compare the efficacy of relamorelin with that of placebo in participants with diabetic gastroparesis (DG) with respect to the core signs and symptoms of diabetic gastroparesis.

Detailed Description

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Conditions

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Gastroparesis Diabetes Mellitus

Keywords

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diabetic gastroparesis vomiting

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Placebo

Placebo injected subcutaneously twice daily for up to 52 weeks. De novo (New) participants, who did not participate in the previous relamorelin studies, began the study with a 2-week placebo run-in.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo injected subcutaneously twice daily.

Relamorelin 10 μg

Relamorelin 10 micrograms (μg) injected subcutaneously twice daily for up to 52 weeks. De novo (New) participants, who did not participate in the previous relamorelin studies, began the study with a 2-week placebo run-in.

Group Type EXPERIMENTAL

Relamorelin

Intervention Type DRUG

Relamorelin 10 μg injected subcutaneously twice daily.

Interventions

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Placebo

Placebo injected subcutaneously twice daily.

Intervention Type DRUG

Relamorelin

Relamorelin 10 μg injected subcutaneously twice daily.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Two different groups of participants may enter into the study:

1. Rollover Participants

Participants who were not randomization-eligible at the end of the Run-in Period of lead-in studies RLM-MD-01 (NCT03285308) or RLM-MD-02 (NCT03426345) are eligible to be randomized in the study if all of the following criteria apply:

•In the lead-in studies, participants must have met all screening visit and Run-in Period criteria for randomization into the Treatment Period (including compliance with dosing, entry of diary data into the Diabetic Gastroparesis Symptom Severity Diary (DGSSD)) except that:
* They had zero vomiting episodes and an average daily Diabetic Gastroparesis Symptom Severity Score (DGSSS) of ≥12 at the end of the lead-in study Run-in Period, as reported using the electronic hand-held device; OR
* They had vomiting episodes and an average daily DGSSS of ≥12 but \<16 at the end of the lead-in study Run-in Period, as reported using the electronic hand-held device
2. De Novo Participants

* Type 1 Diabetes Mellitus (T1DM) or Type 2 Diabetes Mellitus (T2DM) of at least 5 years' duration, with controlled and stable blood glucose levels and hemoglobin A1c (HBA1c) ≤11%
* DG defined as at least a 3-month history prior to Screening of symptoms (one of which must be nausea) on an ongoing basis that are suggestive of gastroparesis (GP) (e.g., nausea, abdominal pain, postprandial fullness, bloating, vomiting, and early satiety)
* Compliance with the entry of data into the hand-held electronic device during the Run-in Period
* Compliance with administration of subcutaneous (SC) twice daily injections during the Run-in Period
* The average of the daily DGSSS from the 2-week, Run-in Period must be ≥12

3. De Novo Participants

* History of anorexia nervosa, binge-eating, bulimia, or other eating disorder within 5 years of the Screening Visit
* History of intestinal malabsorption or pancreatic exocrine insufficiency
* History of belching disorders, other nausea and vomiting disorders
* Gastric or duodenal ulcer within 3 months of Screening
* History of malignancy in the 3 years prior to Screening, except for adequately treated basal cell or squamous cell skin cancer, or in situ cervical cancer
* Currently receiving parenteral feeding or presence of a nasogastric or other enteral tube for feeding or decompression
* Use of metoclopramide, domperidone, prucalopride, macrolide antibiotics (e.g., erythromycin, clarithromycin, azithromycin), or other drugs considered to be GI promotility agents for at least 10 days prior to the start of the Run-in Period
* Currently taking opiates, or expecting to use opiates during the course of the clinical study
* Treatment with glucagon-like peptide-1 (GLP-1) agonist for at least 6 weeks prior to the start of the Run-in Period
* History of pyloric injection of botulinum toxin within 6 months of screening
* History of gastric surgery such as fundoplication, gastrectomy, gastric pacemaker placement, vagotomy, or bariatric procedure (a history of diagnostic endoscopy is not exclusionary)
* Randomization in any previous study in which relamorelin was a treatment
* Allergic to, or intolerant of egg, wheat, milk, or algae, as these are components of the gastric emptying breath test (GEBT) study meal

Exclusion Criteria

1. Both Rollover and De Novo Participants

•Participants with a known allergy or hypersensitivity to the study treatments and their excipients (i.e., mannitol or phenol)
2. Rollover Participants
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Allergan

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Harvy Schneier

Role: STUDY_DIRECTOR

Allergan

Locations

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Pinnacle Research Group

Anniston, Alabama, United States

Site Status

North Alabama Research Center, LLC

Athens, Alabama, United States

Site Status

Simon Williamson Clinic

Birmingham, Alabama, United States

Site Status

Digestive Health Specialist of the South East

Dothan, Alabama, United States

Site Status

G & L Research, LLC

Foley, Alabama, United States

Site Status

Avant Research Associates

Huntsville, Alabama, United States

Site Status

Alabama Medical Group, PC

Mobile, Alabama, United States

Site Status

Phoenix Clinical LLC.

Phoenix, Arizona, United States

Site Status

Del Sol Research Management, LLC

Tucson, Arizona, United States

Site Status

Del Sol Research Management, LLC

Tucson, Arizona, United States

Site Status

Synexus Clinical Research US, Inc.

Tucson, Arizona, United States

Site Status

Preferred Research Partners, Inc.

Little Rock, Arkansas, United States

Site Status

Applied Research Center of Arkansas

Little Rock, Arkansas, United States

Site Status

Arkansas Gastroenterology

North Little Rock, Arkansas, United States

Site Status

Unity Health - Searcy Medical Center

Searcy, Arkansas, United States

Site Status

Hope Clinical Research

Canoga Park, California, United States

Site Status

GW Research Inc

Chula Vista, California, United States

Site Status

Kindred Medical Institute for Clinical Trials, LLC

Corona, California, United States

Site Status

Aurora Care Clinic, LLC

Costa Mesa, California, United States

Site Status

TriWest Research Associates

El Cajon, California, United States

Site Status

Diagnamics Inc.

Encinitas, California, United States

Site Status

VVCRD Research

Garden Grove, California, United States

Site Status

University of California San Diego

La Jolla, California, United States

Site Status

Om Research LLC

Lancaster, California, United States

Site Status

Torrance Clinical Research Institute, Inc.

Lomita, California, United States

Site Status

Angel City Research Inc.

Los Angeles, California, United States

Site Status

Stanford Hospital

Palo Alto, California, United States

Site Status

Optimal Research California

San Diego, California, United States

Site Status

Medical Associates Research Group, Inc

San Diego, California, United States

Site Status

Syrentis Clinical Research

Santa Ana, California, United States

Site Status

Upland Clinical Research

Upland, California, United States

Site Status

Synexus Clinical Research US, Inc.

Vista, California, United States

Site Status

New Hope Research Development

Whittier, California, United States

Site Status

Peak Gastroenterology Associates

Colorado Springs, Colorado, United States

Site Status

Synexus

Colorado Springs, Colorado, United States

Site Status

Gastroenterology Associates of Fairfield County, P.C.

Bridgeport, Connecticut, United States

Site Status

Medical Research Center of Connecticut, LLC

Hamden, Connecticut, United States

Site Status

Innovative Research of West FL, Inc.

Clearwater, Florida, United States

Site Status

Clinical Research of West Florida

Clearwater, Florida, United States

Site Status

ALL Medical Research, LLC

Cooper City, Florida, United States

Site Status

Top Medical Research

Cutler Bay, Florida, United States

Site Status

Palmetto Research, LLC

Hialeah, Florida, United States

Site Status

Vida Clinical Trials

Homestead, Florida, United States

Site Status

Nature Coast Clinical Research

Inverness, Florida, United States

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APF Research LLC

Miami, Florida, United States

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AMPM Research Clinic

Miami, Florida, United States

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Advanced Medical Research Institute

Miami, Florida, United States

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Florida Research Center, Inc.

Miami, Florida, United States

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American Research Institute, Inc

Miami, Florida, United States

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Savin Medical Group LLC

Miami Lakes, Florida, United States

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Gastroenterology Group of Naples

Naples, Florida, United States

Site Status

Sensible Healthcare

Ocoee, Florida, United States

Site Status

Synexus

Pinellas Park, Florida, United States

Site Status

Atlanta Diabetes Associates

Atlanta, Georgia, United States

Site Status

River Birch Research Alliance, LLC

Blue Ridge, Georgia, United States

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Gwinnett Research Institute, LLC

Buford, Georgia, United States

Site Status

Summit Clinical Research, LLC.

Carnesville, Georgia, United States

Site Status

iResearch Atlanta LLC

Decatur, Georgia, United States

Site Status

Infinite Clinical Trials

Riverdale, Georgia, United States

Site Status

Clinical Research Consultants of Atlanta

Suwanee, Georgia, United States

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Rocky Mountain Diabetes and Osteoporosis Center, PA

Idaho Falls, Idaho, United States

Site Status

North Shore University Health System

Evanston, Illinois, United States

Site Status

Southwest Gastroenterology

Oak Lawn, Illinois, United States

Site Status

MediSphere Medical Research Center, LLC

Evansville, Indiana, United States

Site Status

Synexus Clinical Research US, Inc.

Evansville, Indiana, United States

Site Status

American Research, LLC

Jeffersonville, Indiana, United States

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University of Iowa Hospitals and Clinics

Iowa City, Iowa, United States

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University of Kansas Medical Center

Kansas City, Kansas, United States

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Health Science Research Center

Pratt, Kansas, United States

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WestGlen Gastrointestinal Consultants

Shawnee Mission, Kansas, United States

Site Status

Cotton-O'Neil Clinical Research Center - Digestive Health

Topeka, Kansas, United States

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Kansas Medical Clinic

Topeka, Kansas, United States

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Professional Research Network of Kansas, LLC

Wichita, Kansas, United States

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Via Christi Clinic, PA

Wichita, Kansas, United States

Site Status

St. Elizabeth Healthcare â€" Clinical Research Institute

Erlanger, Kentucky, United States

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University of Louisville

Louisville, Kentucky, United States

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WK Physicians Network

Bossier City, Louisiana, United States

Site Status

Avant Research Associates LLC

Crowley, Louisiana, United States

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Cronola LLC

Houma, Louisiana, United States

Site Status

Clinical Trials of SWLA, LLC

Lake Charles, Louisiana, United States

Site Status

Tandem Clinical Research

Marrero, Louisiana, United States

Site Status

Clinical Trials of America, Inc.

West Monroe, Louisiana, United States

Site Status

Metropolitan Gastroenterology Group PC, Chevy Chase Clinical Research

Chevy Chase, Maryland, United States

Site Status

Gastro Center of Maryland

Columbia, Maryland, United States

Site Status

Frederick Gastroenterology Associates, PA an Elligo Health Research Site

Frederick, Maryland, United States

Site Status

Woodholme Gastroenterology Associates, P.A.

Glen Burnie, Maryland, United States

Site Status

Meritus Center for Clinical Research

Hagerstown, Maryland, United States

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Meridian Clinical Research, LLC

Rockville, Maryland, United States

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Clinical Research Institute of Michigan

Chesterfield, Michigan, United States

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Vida Clinical Studies

Dearborn, Michigan, United States

Site Status

Aa Mrc, Llc

Flint, Michigan, United States

Site Status

National Clinical, LLC

Hamtramck, Michigan, United States

Site Status

Gastroenterology Associates of Western Michigan, West Michigan Clinical Research Center

Wyoming, Michigan, United States

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MNGI Digestive Health

Coon Rapids, Minnesota, United States

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Synexus Clinical Research US, Inc.

Richfield, Minnesota, United States

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Synexus Clinical Research US, Inc

St Louis, Missouri, United States

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Montana Medical Research

Missoula, Montana, United States

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Diabetes and Endocrine Associates, P.C.

Omaha, Nebraska, United States

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Heartland Clinical Research, Inc

Omaha, Nebraska, United States

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Excel Clinical Research

Las Vegas, Nevada, United States

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Clinical Research of South Nevada - CROSN

Las Vegas, Nevada, United States

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Advanced Biomedical Research of America

Las Vegas, Nevada, United States

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Digestive Disease Specialists

Las Vegas, Nevada, United States

Site Status

Palm Research Center

Las Vegas, Nevada, United States

Site Status

Garden State Endocrinology LLC

Brick, New Jersey, United States

Site Status

Synexus Clinical Research US, Inc.

Bridgeton, New Jersey, United States

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AGA Clinical Research Associates, LLC

Egg Harbor, New Jersey, United States

Site Status

Lovelace Scientific Resources, Inc.

Albuquerque, New Mexico, United States

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Long Island Gastrointestinal Research Group LLP

Great Neck, New York, United States

Site Status

United Health Services Hospitals, Inc.

Johnson City, New York, United States

Site Status

CHEAR Center LLC

The Bronx, New York, United States

Site Status

Asheville Gastroenterology Associates

Asheville, North Carolina, United States

Site Status

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, United States

Site Status

Carolinas Healthcare-Charlotte

Charlotte, North Carolina, United States

Site Status

Carolina Digestive Health Associates, PA

Concord, North Carolina, United States

Site Status

Cumberland Research Associates, LLC

Fayetteville, North Carolina, United States

Site Status

Triad Clinical Trials

Greensboro, North Carolina, United States

Site Status

Vidant Multispeciality Clinic - Kinston

Kinston, North Carolina, United States

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Diabetes and Endocrinology Consultants, PC

Morehead City, North Carolina, United States

Site Status

PMG Research Salisbury

Salisbury, North Carolina, United States

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PMG Research of Wilmington, LLC

Wilmington, North Carolina, United States

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Trial Management Associates, LLC

Wilmington, North Carolina, United States

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PMG Research of Winston-Salem, LLC

Winston-Salem, North Carolina, United States

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The Center for Clinical Research

Winston-Salem, North Carolina, United States

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Synexus Clinical Research US, Inc.

Akron, Ohio, United States

Site Status

Dayton Gastroenterology,Inc.

Beavercreek, Ohio, United States

Site Status

Diabetes & Endocrinology Associates of Stark County, Inc.

Canton, Ohio, United States

Site Status

Synexus Clinical Research US - Cincinnati

Cincinnati, Ohio, United States

Site Status

Synexus Clinical Research US, Inc

Cincinnati, Ohio, United States

Site Status

Endocrinology Research Associates, Inc.

Columbus, Ohio, United States

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The Ohio State University, Wexner Medical Center

Columbus, Ohio, United States

Site Status

Aventiv Research, Inc.

Columbus, Ohio, United States

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Hometown Urgent Care and Research

Columbus, Ohio, United States

Site Status

CIC America Clinical Inquest Center Ltd.

Dayton, Ohio, United States

Site Status

Hometown Urgent Care and Research

Dayton, Ohio, United States

Site Status

Premier Clinical Research d.b.a. STAT Research

Franklin, Ohio, United States

Site Status

Family Practice Center of Wadsworth, Inc.

Wadsworth, Ohio, United States

Site Status

Centennial Health-Synexus

Oklahoma City, Oklahoma, United States

Site Status

Digestive Disease Specialists Inc

Oklahoma City, Oklahoma, United States

Site Status

Memorial Clinical Research

Oklahoma City, Oklahoma, United States

Site Status

Options Health Research, LLC

Tulsa, Oklahoma, United States

Site Status

Northwest Gastroenterology Clinic, LLC

Portland, Oregon, United States

Site Status

Family Medical Associates, Research Department

Levittown, Pennsylvania, United States

Site Status

Allegheny Endocrinology Associates

Pittsburgh, Pennsylvania, United States

Site Status

Preferred Primary Care Physicians, Inc.

Pittsburgh, Pennsylvania, United States

Site Status

Guthrie Clinical Research

Sayre, Pennsylvania, United States

Site Status

Frontier Clinical Research, LLC

Scottdale, Pennsylvania, United States

Site Status

Frontier Clinical Research, LLC

Smithfield, Pennsylvania, United States

Site Status

Preferred Primary Care Physicians

Uniontown, Pennsylvania, United States

Site Status

Synexus Clinical Research US, Inc.

Anderson, South Carolina, United States

Site Status

Synexus Clinical Research US, Inc

Anderson, South Carolina, United States

Site Status

Clinical Trials of South Carolina

Charleston, South Carolina, United States

Site Status

Carolina Medical Research

Clinton, South Carolina, United States

Site Status

Gastroenterology Associates, PA

Greenville, South Carolina, United States

Site Status

Synexus Clinical Research

Greer, South Carolina, United States

Site Status

Health Concepts

Rapid City, South Dakota, United States

Site Status

Clinsearch

Chattanooga, Tennessee, United States

Site Status

Gastroenterology Centers of the Midsouth

Germantown, Tennessee, United States

Site Status

East Tennessee Research Institute

Johnson City, Tennessee, United States

Site Status

Quality Medical Research

Nashville, Tennessee, United States

Site Status

Texas Clinical Research Institute, LLC

Arlington, Texas, United States

Site Status

DiscoveResearch, Inc.

Beaumont, Texas, United States

Site Status

ClinRx Research, LLC

Carrollton, Texas, United States

Site Status

Baylor College of Medicine Medical Center

Houston, Texas, United States

Site Status

Biopharma Informatic Inc., Research Center

Houston, Texas, United States

Site Status

Houston Endoscopy and Research Center, Inc.

Houston, Texas, United States

Site Status

Rodriguez Clinical Trials

Houston, Texas, United States

Site Status

Amir Hassan, MD, PA

Houston, Texas, United States

Site Status

Sante Clinical Research

Kerrville, Texas, United States

Site Status

Pinnacle Clinical Research

San Antonio, Texas, United States

Site Status

Clinical Trials of Texas, Inc.

San Antonio, Texas, United States

Site Status

Sagact Pllc.

San Antonio, Texas, United States

Site Status

Synexus Clinical Research US, Inc.

San Antonio, Texas, United States

Site Status

Synexus Clinical Research US, Inc.

Layton, Utah, United States

Site Status

Synexus Clinical Research US, Inc.

Murray, Utah, United States

Site Status

Advanced Research Institute, Inc.

Ogden, Utah, United States

Site Status

Advanced Clinical Research

West Jordan, Utah, United States

Site Status

Verity Research Inc.

Fairfax, Virginia, United States

Site Status

Blue Ridge Medical Research

Lynchburg, Virginia, United States

Site Status

Manassas Clinical Research Centre

Manassas, Virginia, United States

Site Status

VA Medical Center McGuire VAMC

Richmond, Virginia, United States

Site Status

Washington Gastroenterology PLLC

Tacoma, Washington, United States

Site Status

West Virginia University

Morgantown, West Virginia, United States

Site Status

Consultorios Asociados de Endocrinologia e Investigación Cl

Buenos Aires, Buenos Aires, Argentina

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Hospital Sirio Libanes

CABA, Buenos Aires, Argentina

Site Status

Centro de Investigaciones Medicas Mar del Plata SRL

Mar del Plata, Buenos Aires, Argentina

Site Status

CIPREC

Buenos Aires, Ciudad Autonoma deBuenos Aires, Argentina

Site Status

Instituto de Investigaciones Clinicas de Rosario

Rosario, Santa Fe Province, Argentina

Site Status

Instituto Medico Catamarca-I.ME.C

Rosario, Santa Fe Province, Argentina

Site Status

Clinica Mayo de Urgencias Medicas Cruz Blanca SRL

San Miguel de Tucumán, Tucumán Province, Argentina

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Centro Universitario de Investigacion en Farmacologia Clinic

Corrientes, , Argentina

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Instituto Privado de Investigaciones Clinicas de Cordoba

Córdoba, , Argentina

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CIDIM - Centro Integral de Diagnóstico por Imágenes Marchegian

Córdoba, , Argentina

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Nepean Hospital

Kingswood, New South Wales, Australia

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Royal Adelaide Hospital - Central Adelaide Local Health Network Incorporated

Adelaide, South Australia, Australia

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Royal Melbourne Hospital

Parkville, Victoria, Australia

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Ordination

Osterreicher, Styria, Austria

Site Status

VIVIT Institute, am LKH Feldkirch

Feldkirch, Vorarlberg, Austria

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Privatklinik wehlre-Diakonissen

Salzburg, , Austria

Site Status

Oö. Gesundheits- und Spitals-AG/LKH Steyr

Steyr, , Austria

Site Status

Universitair Ziekenhuis Antwerpen, Gastro-Enterologie,

Edegem, Antwerp, Belgium

Site Status

UZ Brussel

Jette, Brussels Capital, Belgium

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AZ Sint Lucas Brugge

Bruges, West-Vlaanderen, Belgium

Site Status

Hospital Universitário Walter Cantídio

Fortaleza, Ceará, Brazil

Site Status

Centro de Pesquisa Clinica do Brasil

Brasília, Federal District, Brazil

Site Status

Hospital Universitário João de Barros Barreto - UFPA

Belém, Pará, Brazil

Site Status

Núcleo de Pesquisa Clínica do Rio Grande do Sul

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Instituto Catarinense de Endocrinologia e Diabetes (ICED)

Joinville, Santa Catarina, Brazil

Site Status

Scentryphar Pesquisa Clínica Ltda

Campinas, São Paulo, Brazil

Site Status

Instituto de Pesquisa Clinica em Campinas

Campinas, São Paulo, Brazil

Site Status

Instituto de Estudos e Pesquisas Clinicas do Ceara IEP/CE - Oncology

Fortaleza, , Brazil

Site Status

IPEC-Instituto de Pesquisa Clinica

São Paulo, , Brazil

Site Status

CPQuali Pesquisa Clinica Ltda

São Paulo, , Brazil

Site Status

MHAT Yuliya Vrevska Byala

Byala, Ruse, Bulgaria

Site Status

UMHAT - Kaspela- EOOD

Plovdiv, , Bulgaria

Site Status

Medical Center Asklepion - Humane Medicine Research EOOD

Sofia, , Bulgaria

Site Status

Alexandrovska University Hospital

Sofia, , Bulgaria

Site Status

University of Calgary

Calgary, Alberta, Canada

Site Status

Central Alberta Research Centre

Red Deer, Alberta, Canada

Site Status

Vancouver General Hospital

Vancouver, British Columbia, Canada

Site Status

Patient research centre

St. John's, Newfoundland and Labrador, Canada

Site Status

South Shore Medical Arts

Bridgewater, Nova Scotia, Canada

Site Status

The Ottawa Hospital

Ottawa, Ontario, Canada

Site Status

Toronto Digestive Disease Associates, Inc.

Vaughan, Ontario, Canada

Site Status

Recherche GCP Research

Montreal, Quebec, Canada

Site Status

Rodrigo Botero S.A.S.

Medellín, Antioquia, Colombia

Site Status

Centro Cardiovascular Colombiano Clínica Santa María

Medellín, Antioquia, Colombia

Site Status

Centro Cardiovascular y de Diabetes

Barranquilla, Atlántico, Colombia

Site Status

Fundación del Caribe para la InvestigacionBiomédica-Fundación BIOS

Barranquilla, Atlántico, Colombia

Site Status

Medplus Centro de Recuperacion Integral S.A.S.

Bogotá, Bogota D.C., Colombia

Site Status

Endocare Ltda.

Bogotá, Bogota D.C., Colombia

Site Status

Asociación Colombiana de Diabetes

Bogotá, Cundinamarca, Colombia

Site Status

Healthy Medical Center

Zipaquirá, Cundinamarca, Colombia

Site Status

Centro de Investigaciones Clínicas IPS CARDIOMET Pereira

Pereira, Risaralda Department, Colombia

Site Status

IPS Centro Medico Julian Coronel S.A

Cali, Valle del Cauca Department, Colombia

Site Status

Centro Medico Imbanaco de Cali S.A.

Cali, Valle del Cauca Department, Colombia

Site Status

Steno Diabetes Center Copenhagen

Hellerup, Copenhagen, Denmark

Site Status

Gastroenheden, Hvidovre hospital

Hvidovre, København, Denmark

Site Status

Klinische Forschung Karlsruhe GmbH

Karlsruhe, Baden-Wurttemberg, Germany

Site Status

Studienzentrum Schwittay

Böhlen, Saxony, Germany

Site Status

Klinische Forschung Dresden GmbH

Dresden, Saxony, Germany

Site Status

Clinical Research Hamburg

Hamburg, , Germany

Site Status

Israelitisches Krankenhaus

Hamburg, , Germany

Site Status

KRH Klinikum Siloah

Hanover, , Germany

Site Status

Markhot Ferenc Oktatokorhaz es Rendelointezet

Eger, Heves County, Hungary

Site Status

Hetenyi Geza Hospital

Szolnok, Jász-Nagykun-Szolnok, Hungary

Site Status

Zala Megyei Szent Rafael Korhaz

Zalaegerszeg, Zala County, Hungary

Site Status

Strázsahegy Gyógyszertár Medicina

Budapest, , Hungary

Site Status

Szegedi TudomanyegyetemSzent-Gyorgyi Albert Klinikai Kozpont és Altalanos Orvostudomanyi Kar Belgyogyaszati Klinika

Szeged, , Hungary

Site Status

Kumudini Devi Diabetes Research Center; Ramdevrao Hospital

Hyderabad, Andhra Pradesh, India

Site Status

King George Hospital

Visakhapatnam, Andhra Pradesh, India

Site Status

Dr. Jivraj Mehta Smarak Health Foundation Bakeri Medical Research Centre - Gasterentrology

Ahmedabad, Gujarat, India

Site Status

Zydus Hospital

Ahmedabad, Gujarat, India

Site Status

Lifecare Clinic and Research Centre - Internal Med/Diabetology

Bangalore, Karnataka, India

Site Status

Diacon Hospital and research Center - Diabetology

Bengaluru, Karnataka, India

Site Status

Victoria Hospital Bangalore Medical College and Research Institute

Bengaluru, Karnataka, India

Site Status

Rajalakshmi Hospital

Bengaluru, Karnataka, India

Site Status

Bhatia Hospital

Mumbai, Maharashtra, India

Site Status

B. J. Government Medical College and Sassoon General Hospitals

Pune, Maharashtra, India

Site Status

Universal Hospital

Pune, Maharashtra, India

Site Status

Noble Hospital

Pune, Maharashtra, India

Site Status

S R Kalla (SRK) Memorial Gastro & General Hospital

Jaipur, Rajasthan, India

Site Status

Marudhar Hospital

Jaipur, Rajasthan, India

Site Status

Eternal Hospital - Diabetology

Jaipur, Rajasthan, India

Site Status

SMS Hospital

Jaipur, Rajasthan, India

Site Status

M.V. Hospital for Diabetes & Diabetes Research Centre

Chennai, Tamil Nadu, India

Site Status

Kovai Diabetes Speciality Centre

Coimbatore, Tamil Nadu, India

Site Status

Arthur Asirvatham Hospital

Madurai, Tamil Nadu, India

Site Status

M V Hospital & Research Centre

Lucknow, Uttar Pradesh, India

Site Status

Sir Ganga Ram Hospital (SGRH)

Delhi, , India

Site Status

Vinaya Hospital & Research Centre

Mangalore, , India

Site Status

Bnei-Zion MC

Haifa, , Israel

Site Status

Kraslava Hospital

Krāslava, Kraslavas Nov., Latvia

Site Status

Polana-D

Daugavpils, , Latvia

Site Status

Pauls Stradins Clinical University Hospital, Endokrinologijas nodala

Riga, , Latvia

Site Status

Digestive Diseases Centre GASTRO

Riga, , Latvia

Site Status

Hospital Sultanah Bahiyah

Alor Star, Kedah, Malaysia

Site Status

Clinical Investigation Centre

Kuala Lumpur, , Malaysia

Site Status

Clinical Trial Unit, School of Medical Sciences, Health Campus, Hospital Universiti Sains Malaysia

Kubang Kerian, , Malaysia

Site Status

Hospital Taiping

Taiping, , Malaysia

Site Status

Unidad de Investigacion Clinica Cardiometabolica de Occidente

Guadalajara, Jalisco, Mexico

Site Status

Consultorio particular

Guadalajara, Jalisco, Mexico

Site Status

Unidad de Investigación Clínica en Medicina S.C/

Guadalajara, Jalisco, Mexico

Site Status

Clinicos Asociados BOCM SC

Mexico City, Mexico City, Mexico

Site Status

Mentrials Sa de Cv

Mexico City, Mexico City, Mexico

Site Status

Centro Especializado en Diabetes, Obesidad y Prevencion de E - Endocrinology

Mexico City, Mexico City, Mexico

Site Status

Centro de Atención e Investigación en Factores de Riesgo Car

Mexico City, Mexico City, Mexico

Site Status

Centro de Desarrollo Biomédico S.C.P

Mérida, Yucatán, Mexico

Site Status

Centro de Investigacion Cardiometabolica de Aguascalientes SA de CV

Aguascalientes, , Mexico

Site Status

Hospital Cardiologica Aguascalientes

Aguascalientes, , Mexico

Site Status

Dioderm Instituto de Investigacion

Durango, , Mexico

Site Status

CIADEN (Centro de Investigación y Atención de Diabetes, Endocrinología y Nutrición)

Durango, , Mexico

Site Status

Sociedad de Metabolismo y Corazon S.C.

Veracruz, , Mexico

Site Status

West Visayas State University Medical Center

Iloilo City, IloIlo, Philippines

Site Status

Manila Doctors Hospital, Ermita

Manila, Metropolitan Manila, Philippines

Site Status

San Juan De Dios Educational Foundation, Inc.

Pasay, Metropolitan Manila, Philippines

Site Status

Cardinal Santos Medical Center

San Juan City, National Capital Region, Philippines

Site Status

Ospital ng Makati

Makati City, NCR, Philippines

Site Status

Perpetual Succor Hospital

Cebu City, , Philippines

Site Status

St. Luke's Medical Center

Quezon City, , Philippines

Site Status

Specjalistyczny Gabinet Neurologiczny Marta Banach

Krakow, Lesser Poland Voivodeship, Poland

Site Status

CenterMed Krakow Ltd

Krakow, Malopolska, Poland

Site Status

Centrum Medyczne Lukamed

Chojnice, , Poland

Site Status

Saint-Petersburg City Pokrovskaya Hospital

St-Petersburg, Leningradskaya Oblast', Russia

Site Status

GUZ Saratov City Clinical Hospital 9

Saratov, Saratov Oblast, Russia

Site Status

Scientific Institute of Clinical and Experimental Lymphology

Novosibirsk, , Russia

Site Status

Rostov on Don

Rostov-on-Don, , Russia

Site Status

National University Hospital

Singapore, , Singapore

Site Status

Changi General Hospital

Singapore, , Singapore

Site Status

Singapore General Hospital

Singapore, , Singapore

Site Status

FARMOVS

Bloemfontein, Free State, South Africa

Site Status

Wits Clinical Research

Johannesburg, Gauteng, South Africa

Site Status

Synexus Stanza Clinical Research Centre

Pretoria, Gauteng, South Africa

Site Status

Watermeyer Clinical Research Site

Pretoria, Val de Grace, South Africa

Site Status

Synexus Helderberg Clinical Research Centre

Somerset West, , South Africa

Site Status

Chonbuk National University Hospital

Jeonju, Jeollabuk-do, South Korea

Site Status

Sanggye Paik Hospital, Inje University College of Medicine

Seoul, Nowon-gu, South Korea

Site Status

Asan Medical Center

Seoul, , South Korea

Site Status

Hospital Universitario Principe de Asturias

Madrid, , Spain

Site Status

Phramongkutklao Hospital

Bangkok, , Thailand

Site Status

Faculty of Medicine, Siriraj Hospital, Mahidol University

Bangkok, , Thailand

Site Status

Maharaj Nakorn Chiang Mai Hospital

Chiang Mai, , Thailand

Site Status

State Institution Ukrainian State Research Institute of Medical and Social Problems of Disability of the Ministry of Health of Ukraine

Dnipro, Dnipropetrovsk Oblast, Ukraine

Site Status

Municipal Institution, City Hospital #7, polyclinic department, c. Zaporizhzhia

Zaporizhzhia, Zaporizhzhia Oblast, Ukraine

Site Status

Chernivtsi Regional Clinical Hospital

Chernivtsi, , Ukraine

Site Status

Regional Municipal noncommercial Enterprise "Chernivtsi Regional Endocrinology Center", Polyclinic department, Higher State Educational Establishment of Ukraine "Bukovinian State Medical University", Department of Clinical Immunology, Allergology and Endo

Chernivtsi, , Ukraine

Site Status

Ivano-Frankivsk National Medical University

Ivano-Frankivsk, , Ukraine

Site Status

Ivano-Frankivsk Central City Clinical Hospital

Ivano-Frankivsk, , Ukraine

Site Status

Municipal nonprofit entity of Kharkiv municipal council

Kharkiv, , Ukraine

Site Status

Clinical Endocrinology of SI "V.Danilevsky Institute for endocrine pathology problems National Academy of Medical sciences of Ukraine"

Kharkiv, , Ukraine

Site Status

Communal Institution Kherson City Clinical Hospital

Kherson, , Ukraine

Site Status

Kyiv Railway Clinical Hospital No-2 of Branch of Healthcare Center of the PJSC Ukrainian Railway , Endocrynology Department

Kyiv, , Ukraine

Site Status

Polyclinic of medical services and rehabilitation department of State Joint-Stock Holding Company Artem, day-patient unit

Kyiv, , Ukraine

Site Status

Odessa Railway Clinical Hospital of Branch of HC JSC Ukrzaliznytsia, Odessa National Medical University

Odesa, , Ukraine

Site Status

Poltava Regional Clinical Hospital

Poltava, , Ukraine

Site Status

Private Small-Scale Enterprise Medical Centre Pulse

Vinnytsia, , Ukraine

Site Status

Vinnytsia Regional Clinical highly specialized Endocrinology Centre

Vinnytsia, , Ukraine

Site Status

Municipal Institution 6th City Clinical Hospital, Dept of Gastroenterology

Zaporizhzhia, , Ukraine

Site Status

Biomedical Research Centre

Nottingham, East Midland, United Kingdom

Site Status

MAC Clinical Research Manchester

Manchester, Greater Manchester, United Kingdom

Site Status

Royal Oldham Hospital

Oldham, Lancashire, United Kingdom

Site Status

MAC Clinical Research

Liverpool, Merseyside, United Kingdom

Site Status

MAC Research, Exchange House

Cannock, Staffordshire, United Kingdom

Site Status

University Hospitals of North Midlands

Stoke-on-Trent, Staffordshire, United Kingdom

Site Status

MAC Clinical Research, Monarch House

Leeds, West Yorkshire, United Kingdom

Site Status

MAC Research

Barnsley, , United Kingdom

Site Status

MAC Clinical Research, Kaman Court

Blackpool, , United Kingdom

Site Status

Mid Essex Hospital Services NHS Trust Broomfield Hospital

Chelmsford, , United Kingdom

Site Status

MAC Clinical Research, GAC House

Manchester, , United Kingdom

Site Status

Countries

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France Italy Romania Saudi Arabia United States Argentina Australia Austria Belgium Brazil Bulgaria Canada Colombia Denmark Germany Hungary India Israel Latvia Malaysia Mexico Philippines Poland Russia Singapore South Africa South Korea Spain Thailand Ukraine United Kingdom

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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2017-002144-33

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

RLM-MD-04

Identifier Type: -

Identifier Source: org_study_id