Electrical Stimulation Combined With Motor Training on EEG-EMG Coherence and Motor Function in Individuals With Stroke

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-08-28

Study Completion Date

2017-01-04

Brief Summary

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This study investigated whether electrical stimulation (ES) prior to a hand function training session for a total of eight weeks can better improve neuromuscular control and hand function in subacute stroke individuals and change electroencephalography-electromyography (EEG-EMG) coherence, as compared to the control (sham ES).

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Detailed Description

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Subjects were randomly assigned into ES and control groups. Both groups received 20-minute hand function training twice a week, and the ES group received 40-minute ES on the median nerve of the affected side before each training session. The control group received sham ES - electrodes were placed on the same location but no electric current was applied. EEG, EMG and Fugl-Meyer Assessment (FMA) were collected before, at the 4th week, at the end of 8th week, and 4 weeks after the end of intervention.

Conditions

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Stroke

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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Electrical stimulation

Group Type EXPERIMENTAL

Electrical stimulation

Intervention Type OTHER

sensory electrical stimulation was applied prior to upper limb functional training

Control

Group Type SHAM_COMPARATOR

Sham electrical stimulation

Intervention Type OTHER

electrodes were placed on the same location as the Electrical stimulation condition, but no electric current was applied

Interventions

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Electrical stimulation

sensory electrical stimulation was applied prior to upper limb functional training

Intervention Type OTHER

Sham electrical stimulation

electrodes were placed on the same location as the Electrical stimulation condition, but no electric current was applied

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. first-ever cerebral cortical region involved chronic stroke, onset over a month,
2. able to perform active thumb flexion on the affected side with the scores of manual muscle test at least two points, and
3. at stable medical condition for intervention

Exclusion Criteria

1. history of other neurological disorders,
2. cognitive impairment (Mini-Mental State Examination score \<24, MMSE),26
3. unable to follow orders,
4. contraindications of ES, and
5. under 20 years old

Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No