Management of Obstructive Sleep Apnea (OSA) in Children and Maxillary and Mandibular Development

NCT ID: NCT03267927

Last Updated: 2020-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

4 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-11-05

Study Completion Date

2019-03-25

Brief Summary

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Assessment of the association of maxillary expansion using a rapid palatal expansion, use of a mandibular advancement appliance (MGA™) and of a device allowing sleep in a semi-seated position (Yoobreath™) in patients with Obstructive Sleep Apnea (OAS). MGA™ and YooBreath™ constitute the Yookid system™.

Detailed Description

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Obstructive Sleep Apnea syndrome (OSA) shows a 10% morbidity rate in children with a higher rate between the ages of 3 and 5. Generally speaking, its prevalence is underestimated. Furthermore, detecting OSA remains difficult due to its particular physiopathology. The decrease in nasopharyngeal airway dimensions is the most common etiology. This decrease is related to soft tissues as well as maxillomandibular abnormalities. The aim of the study is to show that reducing sleep apnea in children remains possible when inducing rapid palatal expansion and mandibular advancement using the Yookid™ system. The Yookid™ system associates a mandibular advancement appliance and repositioning of the patient during sleep.

Conditions

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Obstructive Sleep Apnea Syndrome

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Patient with OSA

Group Type EXPERIMENTAL

Rapid palatal expansion

Intervention Type DEVICE

Fixation of rapid palatal expansion from day 0 to day 60

MGA™ system

Intervention Type DEVICE

Use of a mandibular advancement Appliance during the night from day 60 to day 180 (end of treatment from day 120 if Angle Class I is obtained)

Yoobreath™ system

Intervention Type DEVICE

Use of a device allowing sleep in a semi-seated position during the night from day 15 to day 180 (end of treatment from day 120 if Angle Class I is obtained)

Interventions

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Rapid palatal expansion

Fixation of rapid palatal expansion from day 0 to day 60

Intervention Type DEVICE

MGA™ system

Use of a mandibular advancement Appliance during the night from day 60 to day 180 (end of treatment from day 120 if Angle Class I is obtained)

Intervention Type DEVICE

Yoobreath™ system

Use of a device allowing sleep in a semi-seated position during the night from day 15 to day 180 (end of treatment from day 120 if Angle Class I is obtained)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* 5 to 7 year-old children
* Children with American Society of Anesthesiologists score (ASA) of 1 and 2
* Children with signs of OSA during examination and clinical exam
* Children with apnea-hypopnea index (AHI) from 1 to 5 (one to five sleep apnea / hour during PSG)
* Children with a class II division 1 angle malocclusion (at the canines level rotation center) and skeletal class II according to Delaire analysis

Exclusion Criteria

* OSA associated to syndromic disorder and/or syndrome
* Body/Mass Index (BMI) \> 97ème percentile according to development curves (obese children)
* Central sleep apnea
* Respiratory allergy
* Previous ear, nose and throat (ENT) surgery
* Hypertrophic tonsils needing surgery
* Adenoid hypertrophy needing surgery
* Patients with ankyloglossia
Minimum Eligible Age

5 Years

Maximum Eligible Age

7 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rennes University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU de Rennes

Rennes, , France

Site Status

Countries

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France

Other Identifiers

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35RC16_9851_SAOS

Identifier Type: -

Identifier Source: org_study_id

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