Effect of Antigens or Therapeutic Agents on in Vitro Human Intestinal Organoids

NCT ID: NCT03256266

Last Updated: 2024-07-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

375 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-04-01

Study Completion Date

2025-07-31

Brief Summary

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The study evaluates the effect of nutrient antigens or therapeutic agents on human small intestinal organoids.

Detailed Description

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Small intestinal biopsies will be taken to establish human intestinal organoids in vitro. The organoids will be propagated and various antigens will be checked for their effects on proliferation, production of inflammatory components or signal cascade.

Conditions

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Intestine Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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healthy controls

healthy controls

No interventions assigned to this group

patients with allergy

patients with Food intolerances or Food allergy

No interventions assigned to this group

gastrointestinal disorders

patients with inflammatory bowel disease, irritable bowel disease, gluten sensitivity, short bowel syndrome

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* patients with gastrointestinal disorders and therapeutical indication of gastroduodenoscopy or coloscopy
* healthy controls for preventive medical check-up

Exclusion Criteria

* pregnant women
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Erlangen-Nürnberg Medical School

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-University Erlangen-Nuremberg

Erlangen, , Germany

Site Status

Countries

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Germany

Other Identifiers

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intestinal organoids

Identifier Type: -

Identifier Source: org_study_id

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