Study Results
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Basic Information
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COMPLETED
NA
110 participants
INTERVENTIONAL
2016-09-30
2023-12-27
Brief Summary
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Detailed Description
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This model is of interest to study early pathophysiological events occurring within intestinal epithelium, in the context of FAP and inflammatory bowel diseases (IBD). An excessive proliferation or an abnormal healing is found in FAP and IBD respectively. Investigators hypothesized that it could specifically involved one of the 2 ISCs. Columnar basal cells (CBC) and ISC located at the +4 position from the bottom of the crypt (ISC+4) can both differentiate into absorptive or secretory intestinal epithelial cells. However, CBC and ISC+4 could have different metabolic, migratory functions, or stress survival.
Investigators designed a monocentric pilot study to develop intestinal organoids from endoscopic biopsies of IBD (Crohn and ulcerative colitis), FAP patients and healthy controls. Investigators plan to investigate the morphological characteristics of organoids, the expression of genes and proteins of the Wnt/APC/beta-catenin pathway within both ISC. Will also be studied the expression of key genes of tumor initiation (PTEN, BMPR1A, p53 and KRAS) and inflammatory parameters (cytokines and lipid mediators).
The results of this study could improve the understanding of intestine renewal. Later on, the development of new drugs could beneficiate to IBD and FAP patients.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Crohn disorder
arm composed by 30 patients with Crohn disorder
Endoscopic biopsies
intestinal biopsies
FAP (familial adenomatous polyposis )
arm composed by 30 patients with FAP disorder
Endoscopic biopsies
intestinal biopsies
ulcerative colitis
arm composed by 30 patients with ulcerative colitis
Endoscopic biopsies
intestinal biopsies
witness
arm composed by 30 patients with no intestinal disorders
Endoscopic biopsies
intestinal biopsies
Interventions
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Endoscopic biopsies
intestinal biopsies
Eligibility Criteria
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Exclusion Criteria
3 Years
ALL
Yes
Sponsors
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University Hospital, Toulouse
OTHER
Responsible Party
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Principal Investigators
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Emmanuel MAS, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Toulouse
Locations
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Hopital des Enfants
Toulouse, , France
Countries
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References
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Laborde N, Barusseaud A, Quaranta M, Rolland C, Arrouy A, Bonnet D, Kirzin S, Sola-Tapias N, Hamel D, Barange K, Duffas JP, Gratacap MP, Guillermet-Guibert J, Breton A, Vergnolle N, Alric L, Ferrand A, Barreau F, Racaud-Sultan C, Mas E. Human colonic organoids for understanding early events of familial adenomatous polyposis pathogenesis. J Pathol. 2025 Jan;265(1):26-40. doi: 10.1002/path.6366. Epub 2024 Dec 6.
Moreau J, Mas E. Drug resistance in inflammatory bowel diseases. Curr Opin Pharmacol. 2015 Dec;25:56-61. doi: 10.1016/j.coph.2015.11.003. Epub 2015 Nov 29.
Other Identifiers
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RC31/15/7816
Identifier Type: -
Identifier Source: org_study_id
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