Blood Pressure Lowering Effects of Amosartan Regarding Proviso iN Patients With High Blood Pressure

NCT ID: NCT03255551

Last Updated: 2017-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-01

Study Completion Date

2015-12-31

Brief Summary

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Blood Pressure Lowering Effects of Amosartan Regarding Proviso in Patients with Hypertension

Detailed Description

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After taking Amozatan (AMS, amlodipine / rozanthin combination) in patients with essential hypertension, the percentage of patients who reached the mean systolic target blood pressure was evaluated

Conditions

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Hypertension

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Interventions

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Amosartan

amosartan is a combination of amlodipine, which is a calcium channel blocker (CCB), and rozatan, an angiotensin II receptor antagonist (ARB), and is an antihypertensive agent

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with essential hypertension whose blood pressure is not adequately controlled by amlodipine or rosartan monotherapy
* In patients with stage 2 hypertension (SBP 160-179 mmHg), patients requiring a combination therapy to reach the target blood pressure
* Patients who were changed to amosartan while using other hypertensive agents

Exclusion Criteria

* Patients with hypersensitivity to dihydropyridine derivatives of amosartan
* Women who are pregnant or who may be pregnant and breastfeeding
* Patients with severe hepatic dysfunction
* Patients with severe aortic stenosis
* Patients at risk of shock
* Patients participating in other clinical studies
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Bundang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Dong-Ju Choi

Seoul National University Bundang Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Kim SH, Ryu KH, Lee NH, Kang JH, Kim WS, Park SW, Lee HY, Kim JJ, Ahn YK, Suh SY. Efficacy of fixed-dose amlodipine and losartan combination compared with amlodipine monotherapy in stage 2 hypertension: a randomized, double blind, multicenter study. BMC Res Notes. 2011 Oct 28;4:461. doi: 10.1186/1756-0500-4-461.

Reference Type BACKGROUND
PMID: 22035131 (View on PubMed)

Law MR, Wald NJ, Morris JK, Jordan RE. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials. BMJ. 2003 Jun 28;326(7404):1427. doi: 10.1136/bmj.326.7404.1427.

Reference Type BACKGROUND
PMID: 12829555 (View on PubMed)

Choi SM, Seo MJ, Kang KK, Kim JH, Ahn BO, Yoo M. Beneficial effects of the combination of amlodipine and losartan for lowering blood pressure in spontaneously hypertensive rats. Arch Pharm Res. 2009 Mar;32(3):353-8. doi: 10.1007/s12272-009-1307-x. Epub 2009 Apr 23.

Reference Type BACKGROUND
PMID: 19387578 (View on PubMed)

Other Identifiers

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LEARN BP

Identifier Type: -

Identifier Source: org_study_id

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