Glucocorticoid Antagonist Treatment for Tobacco Use Disorder

NCT ID: NCT03248713

Last Updated: 2019-05-28

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: EARLY_PHASE1
• Total Enrollment: 8 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-11-29
• Study Completion Date: 2019-05-20

Brief Summary

The purpose of this protocol is to examine whether mifepristone, a medication with glucocorticoid receptor antagonist activity, may be a potential treatment for Tobacco Use Disorder (TUD). Mifepristone has already shown promise as a potential treatment for PTSD (1) and alcohol use disorder (AUD) (2), but no previous studies have examined the therapeutic potential of mifepristone for TUD. This will be a double-blind, placebo-controlled study on the effects of a 7-day treatment with 600 mg mifepristone, or placebo, on cognitive function, tobacco withdrawal severity, and smoking behavior.

Detailed Description

This will be a double-blind, placebo-controlled study that tests the effects of a 7-day treatment with 600 mg mifepristone, or placebo, on cognitive function, tobacco withdrawal severity and smoking behavior. Once the intake and physical examination is completed and eligibility is determined, subjects will participate in a baseline session to become familiar with the study procedures and to assess baseline measures of withdrawal, smoking urges, pain sensitivity, and cognitive performance. Subjects will be asked to refrain from consuming alcoholic beverages and drugs during their study participation. This will be verified by urine drug screening and breathalyzer before the session and during outpatient visits. If results indicate non-compliance with these study procedures, subjects will be discharged from the study.

Participants will be assessed for compliance with medication treatment, withdrawal severity, recent smoking behavior, and cognitive function during treatment visits on Days 1 and 4. On Day 7, following overnight abstinence from smoking, participants will attend a test session that models relapse to smoking. During this session, subjects will have the option to smoke, or to delay smoking in exchange for monetary compensation (45). To examine if mifepristone's proposed therapeutic effects last beyond the treatment duration (as observed in previous studies), there will be 1-week and 1-month follow-up assessments on smoking behavior, urges to smoke, endocrine biomarkers, and cognitive function.

Participants in each group will complete the laboratory-based, delayed smoking procedure in a designated, negative pressure room in Bldg. 36 of the West Haven VA just after assessing pain sensitivity with the cPT. This sequence allows the cPT to assess pain sensitivity, a potential biomarker of relapse behavior, and to also be used as a mild stressor prior to participation in the smoking relapse model. Participants will be instructed to abstain from smoking after 10 pm the night before Test Sessions. Abstinence will be confirmed the morning of the session by measuring a breath CO level of < 8 ppm.

Conditions

Nicotine Dependence

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: DOUBLE

Study Groups

Mifepristone

Mifepristone 600 mg/day in 2 tablets

Group Type: ACTIVE_COMPARATOR

Placebo

Intervention Type: DRUG

Placebo sugar 2 tablets will be compared to mifepristone

Placebo

matching placebo in 2 tablets

Group Type: PLACEBO_COMPARATOR

Mifepristone

Intervention Type: DRUG

Mifepristone 600mg 2 tablets will be compared to the placebo

Interventions

Mifepristone

Mifepristone 600mg 2 tablets will be compared to the placebo

Intervention Type: DRUG

Placebo

Placebo sugar 2 tablets will be compared to mifepristone

Intervention Type: DRUG

Other Intervention Names

korlym, mifeprex; sugar pill

Eligibility Criteria

Inclusion Criteria

• Male smokers aged 18 to 55 years;
• History of smoking at least 5 cigarettes daily for the past 12 months;
• In good health as verified by medical history, screening examination, and -screening laboratory tests

Exclusion Criteria

• History of mifepristone allergy;
• Requirement of any form of regular psychotropic medication (antidepressants, antipsychotics, or anxiolytics) and recent psychiatric history (in the past 6 months);
• Medical illnesses including diabetes, cardiovascular, renal, endocrine, or hepatic disorders;
• Prolonged QTc interval >450 msec;
• History of adrenal insufficiency or a morning plasma cortisol level less than 5 mcg/dl at screening;
• Hypokalemia at screening (defined as potassium level < 3.5 mEq/L);
• Current use of clinically significant CYP 3A4 substrates including, simvastatin, lovastatin, cyclosporine, ergotamines, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, triazolam, midazolam.
• use of rifapentin, phenobarbital, phenytoin, carbamazepine, and St. John's Wort.
• Current use of strong 3A4 inhibitors including ketoconazole, itraconazole, nefazodone, ritonavir, nelfinavir, indinavir, atazanavir, amprenavir, fosamprenivir, boceprevir, clarithromycin, conivaptan, lopinavir, mibefradil, posaconazole, saquinavir, telaprevir, telithromycin, voriconazole.
• Treatment with systemic corticosteroids
• Current use of clinically significant CYP 3A inducers (e.g., rifampin, rifabutin);
• Abuse of alcohol or any other illicit or prescription drugs;
• Inability to tolerate cold exposure due to conditions such as peripheral -vascular disease or Raynaud's phenomenon;
• Inability to fulfill all scheduled visits and examination procedures throughout the study period.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

Yale University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Mehmet Sofuoglu, M.D.,Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Yale University

Locations

Veterans Affairs Hospital

West Haven, Connecticut, United States

Countries

United States

Other Identifiers

MS053

Identifier Type: -

Identifier Source: org_study_id