Vitamin A Kinetics and Mathematical Modeling in American Women

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

8 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-03-31

Study Completion Date

2016-10-31

Brief Summary

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Women were given a vitamin A tracer, and blood was sampled to determine individual and group vitamin A kinetics. Data were subsequently modeled using compartmental analysis to determine effects of study length on model outcomes.

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Detailed Description

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This is a longitudinal study in which American women were given an oral, stable isotope tracer of vitamin A, and blood was sampled in a staggered, serial design to determine individual and group vitamin A kinetics. Data were subsequently modeled using compartmental analysis, and study truncation analysis was performed on data to investigate the factor of study duration on resulting vitamin A kinetic models and outputs related to vitamin A metabolism.

Conditions

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Vitamin A Kinetics

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Vitamin A tracer

A stable isotope tracer of vitamin A was given orally.

Group Type EXPERIMENTAL

Vitamin A tracer

Intervention Type OTHER

A stable isotope tracer of vitamin A was given orally.

Interventions

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Vitamin A tracer

A stable isotope tracer of vitamin A was given orally.

Intervention Type OTHER

Other Intervention Names

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13C vitamin A 13C retinyl acetate

Eligibility Criteria

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Inclusion Criteria

* BMI (18.5 - 24.9 kg/m2)

Exclusion Criteria

* Smoker
* Pregnant
* Trying to become pregnant
* Lactating
* Weight loss \> 4.5 kg during the past 3 months.
* Actively trying to lose weight
* Inability to refrain from drinking alcohol when requested
* Amenorrhea
* Acute or chronic illness including hepatitis
* Current or previous history of anorexia or bulimia
* Concurrent participation in other studies
* Family member already enrolled in the study

Minimum Eligible Age

19 Years

Maximum Eligible Age

30 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes