Cardiac Function and Metabolism in Young Adults Born Premature (PET-MRI)

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

52 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-09-20

Study Completion Date

2020-02-26

Brief Summary

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The purpose of this research is to determine the effect of premature birth on later heart function and metabolism.

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Detailed Description

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The purpose of this study is to determine the effects of premature birth on cardiac function, cardiac metabolism, and oxidative stress in a cohort of young adults born prematurely using cardiac positron emission tomography/magnetic resonance imaging and mitochondrial respiration studies.

Conditions

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Infant,Premature

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Young adults born premature (some of them are registered on the National Lung Project) and Healthy Controls will undergo pulmonary function testing, cardiac positron emission tomography, and cardiac magnetic resonance imaging.

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Preterm

Participants born premature either registered on the National Lung Project (currently in their late twenties) or not registered on the National Lung Project Cohort (current age ranges 18-35 years).

All the participants in this group will undergo Pulmonary Function Testing, Electrocardiogram, Positron Emission Tomography, and Magnetic Resonance Imaging.

Group Type ACTIVE_COMPARATOR

Pulmonary Function Testing

Intervention Type PROCEDURE

Subjects will undergo Spirometry and Plethysmography

Electrocardiogram

Intervention Type PROCEDURE

Subjects will undergo an electrocardiogram to ensure sinus rhythm

Positron Emission Tomography

Intervention Type PROCEDURE

Subjects will undergo positron emission tomography to detect images of the heart

Magnetic Resonance Imaging

Intervention Type PROCEDURE

Subjects will undergo positron magnetic resonance imaging to detect images of the heart

Term - Healthy Controls

Healthy individuals that were not born premature. Individuals are ages 18-35. Subjects will undergo Pulmonary Function Testing, Electrocardiogram, Positron Emission Tomography, and Magnetic Resonance Imaging.

Group Type PLACEBO_COMPARATOR

Pulmonary Function Testing

Intervention Type PROCEDURE

Subjects will undergo Spirometry and Plethysmography

Electrocardiogram

Intervention Type PROCEDURE

Subjects will undergo an electrocardiogram to ensure sinus rhythm

Positron Emission Tomography

Intervention Type PROCEDURE

Subjects will undergo positron emission tomography to detect images of the heart

Magnetic Resonance Imaging

Intervention Type PROCEDURE

Subjects will undergo positron magnetic resonance imaging to detect images of the heart

Interventions

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Pulmonary Function Testing

Subjects will undergo Spirometry and Plethysmography

Intervention Type PROCEDURE

Electrocardiogram

Subjects will undergo an electrocardiogram to ensure sinus rhythm

Intervention Type PROCEDURE

Positron Emission Tomography

Subjects will undergo positron emission tomography to detect images of the heart

Intervention Type PROCEDURE

Magnetic Resonance Imaging

Subjects will undergo positron magnetic resonance imaging to detect images of the heart

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* National Lung Project Cohort only- birth weight \<1500g and a gestational age \<36 weeks
* Adults born preterm (Non-National Lung Project) only- gestational age ≤32 weeks OR birth weight ≤ 3lbs 5oz
* Healthy Controls only- No personal history of known cardiovascular or pulmonary disease

Exclusion Criteria

* Metabolic Disorders that would affect Fludeoxyglucose uptake
* Contraindications to positron emission tomography and/or magnetic resonance imaging
* Pregnancy, if a female of child-bearing potential
* A personal history of Type I or Type II diabetes

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes