Effect of Bacterial Translocation on Haemodynamic and Coagulation Parameters During Liver Transplantation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-08-03

Study Completion Date

2017-11-14

Brief Summary

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The present study is to demonstrate the effect of the presence of bacterial translocation detected by bacterial deoxyribonucleic acid (bactDNA) in blood and ascites using the polymerase chain reaction (PCR) on some haemodynamic and coagulation parameters during a liver transplant procedure.

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Detailed Description

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Conditions

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Effect of Bacterial Translocation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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DNA positive patients

patients who have bacterial DNA in their samples

PCR for bacterial translocation

Intervention Type DIAGNOSTIC_TEST

samples taken from the blood and ascites of patients to search for bacterial DNA

DNA negative patients

patients who do not have bacterial DNA in their samples

PCR for bacterial translocation

Intervention Type DIAGNOSTIC_TEST

samples taken from the blood and ascites of patients to search for bacterial DNA

Interventions

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PCR for bacterial translocation

samples taken from the blood and ascites of patients to search for bacterial DNA

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

• patients with liver failure undergoing liver transplantation

Exclusion Criteria

* Age less than 18 years;
* Active overt infection;
* Patients on oral or systemic anticoagulation or with known coagulopathic disorders apart from those caused by liver failure (eg.: Protein C or S deficiency, congenital platelet disorders and congenital coagulation disorders…etc);
* Patients undergoing re-transplantation.

Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No