Application of Proteome Profiler Antibody Arrays to Find Angiogenetic Predictors in Glioma Paitents.

NCT ID: NCT03225963

Last Updated: 2017-07-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-08-01

Study Completion Date

2018-07-31

Brief Summary

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Bevacizumab has become the standard of care of recurrent glioblastoma based on promising clinical trial results with with response rates up to 50% and progression-free survival up to 9 months. In our study, we set to find the serum angiogenesis biomarkers of bevacizumab response.

Detailed Description

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Pre-chemoradiation and post-chemoradiation peripheral blood will be obtained to see if there are some angiogenesis biomarker available for prediction of bevacizumab response later.

Conditions

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Glioblastoma Multiforme Angiogenesis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Chemoradiation with temozolomide

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Age older than 20 year old.
* Glioblastoma patients who will receive chemoradiation treatment.

Exclusion Criteria

* None
Minimum Eligible Age

20 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Taichung Veterans General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Weir Chiang You, M.D. Ph.D.

Role: STUDY_CHAIR

The Institutional Review Board of Taichung Veterans General Hospital

Locations

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Taichung Veterans General Hospital

Taichung, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Weir Chiang You, M.D. Ph.D.

Role: CONTACT

886-4-23592525 ext. 5602

Hui Lin Yeh, M.D.

Role: CONTACT

886-4-23592525 ext. 5621

Facility Contacts

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Weir Chiang You, M.D. PhD

Role: primary

886-4-23592525 ext. 5602

References

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Lamszus K, Ulbricht U, Matschke J, Brockmann MA, Fillbrandt R, Westphal M. Levels of soluble vascular endothelial growth factor (VEGF) receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A. Clin Cancer Res. 2003 Apr;9(4):1399-405.

Reference Type BACKGROUND
PMID: 12684411 (View on PubMed)

Reynes G, Vila V, Martin M, Parada A, Fleitas T, Reganon E, Martinez-Sales V. Circulating markers of angiogenesis, inflammation, and coagulation in patients with glioblastoma. J Neurooncol. 2011 Mar;102(1):35-41. doi: 10.1007/s11060-010-0290-x. Epub 2010 Jul 6.

Reference Type BACKGROUND
PMID: 20607353 (View on PubMed)

Other Identifiers

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CE15180B

Identifier Type: -

Identifier Source: org_study_id

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