Border Zone Stereotactic Radiosurgery With Bevacizumab in Patients With Glioblastoma Multiforme

NCT ID: NCT02120287

Last Updated: 2019-05-07

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 16 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-05-31
• Study Completion Date: 2018-03-31

Brief Summary

This is a phase II study on the usage of stereotactic Gamma Knife radiosurgery as a boost to the tumor bed border zone in conjunction with the usage of bevacizumab.

Detailed Description

Glioblastoma Multiforme (GBM) is the most common primary brain tumor in adults. Unfortunately, despite aggressive surgery, radiation therapy (RT) and chemotherapy, the prognosis for this disease is poor. It is our hypothesis that GBM is a "local" disease wherein treatment failure is due to failure to eradicate tumor cells in the pathways along which the tumor eventually spreads (the "border zone").

The investigators hypothesize that treatment volume escalation will be successful at improving overall survival in patients with GBM when appropriate targeting and precision dose delivery is performed in a single treatment session. The 'border zone' of the tumor will be targeted for SRS (defined as a combination of the MRI volume of gadolinium enhancement plus up to 2 cm of the surrounding T2 volume). This represents the volume of tumor infiltrated white matter and is the route of GBM spread. Bevacizumab, a monoclonal antibody to vascular endothelial growth factor (VEGF), has been used with safety and clinical success with concomitant chemotherapy in solid tumors, including GBM.

The investigators further hypothesize that a combined approach of SRS with this VEGF inhibitor will be an effective strategy for GBM because bevacizumab will maximize the effects of radiation in the treated volume and potentially reduce radiation toxicity in the adjacent brain.

Conditions

Glioblastoma Multiforme; Glioblastoma - Category

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

BZ-SRS with Bevacizumab

All patients will receive Border Zone Stereotactic Radiosurgery (BZ-SRS) and additionally receive bevacizumab (10 mg/kg) one day before and then at day 14 followed by 10 mg/kg/day every 14 days until progression.

One to 14 days before BZ- SRS procedure, patients at centers with MRS experience will undergo standard brain MRI /MRS

Group Type: EXPERIMENTAL

Bevacizumab

Intervention Type: DRUG

Patients will receive bevacizumab (10 mg/kg) one day before and then at day 14 followed by10 mg/kg/day every 14 days until progression.

Magnetic Resonance Spectroscopy (MRS)

Intervention Type: PROCEDURE

Subjects will have MRS prior to BZ-SRS.

Border Zone Stereotactic Radiosurgery (BZ-SRS)

Intervention Type: PROCEDURE

The 'border zone' of the tumor will be targeted by SRS in a single session.

Interventions

Bevacizumab

Patients will receive bevacizumab (10 mg/kg) one day before and then at day 14 followed by10 mg/kg/day every 14 days until progression.

Intervention Type: DRUG

Magnetic Resonance Spectroscopy (MRS)

Subjects will have MRS prior to BZ-SRS.

Intervention Type: PROCEDURE

Border Zone Stereotactic Radiosurgery (BZ-SRS)

The 'border zone' of the tumor will be targeted by SRS in a single session.

Intervention Type: PROCEDURE

Other Intervention Names

Avastin; GammaKnife

Eligibility Criteria

Inclusion Criteria

1. Histologically confirmed glioblastoma multiforme, WHO grade IV astrocytoma.

2. Prior first-line treatment with surgery or biopsy followed by fractionated radiotherapy with concurrent temozolomide-containing chemotherapy is required for glioblastoma patients. Additional prior chemotherapy is allowed, without limitation on number of recurrences.

3. An interval of at least 2 months since completion of fractionated radiotherapy.

4. Age > 18 years

5. Life expectancy of at least 12 weeks.

6. Karnofsky Performance Status score (KPS) of ≥ 60

7. Documented recurrent disease; Disease must be evaluable, but does not need to be measurable; the target site for SRS does not need to be located in a previously-irradiated area.

8. All patients must have no restrictions to obtaining MRI with and without gadolinium contrast.

9. Adequate bone marrow, hepatic and renal function ; BUN < 25 and Cr < 1.7

10. Negative pregnancy test at the time of SRS in any patient who could be pregnant.

11. Willingness to forego additional therapy until evidence of disease progression

Exclusion Criteria

1. General Medical Exclusions:

1. Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study.

2. Active malignancy, other than superficial basal cell and superficial squamous (skin) cell, or carcinoma in situ of the cervix within last 3 years.

3. Prior radiosurgery

4. Prior intracavitary irradiation or Gliadel wafers.

2. Disease-Specific Exclusions:

1. Inability to comply with protocol or study procedures

2. Prior treatment with bevacizumab.

3. Inability to undergo MRI with and without contrast administration.

3. Bevacizumab-Specific Exclusions:

1. Inadequately controlled hypertension.

2. Prior history of hypertensive crisis or hypertensive encephalopathy.

3. New York Heart Association (NYHA) Grade II or greater congestive heart failure.

4. History of myocardial infarction or unstable angina within 6 months prior to Day 1.

5. History of stroke or transient ischemic attack within 6 months prior to Day 1.

6. Significant vascular disease within 6 months prior to Day 1.

7. History of hemoptysis within 1 month prior to Day 1.

8. Evidence of bleeding diathesis or significant coagulopathy

9. Major surgical procedure, open biopsy, or significant traumatic injury within 14 days prior to Day 1 or anticipation of need for major non -cranial surgical procedure during the course of the study.

10. Core biopsy or other minor surgical procedure, excluding placement of a vascular access device, within 7 days prior to Day 1.

11. History of abdominal fistula or gastrointestinal perforation within 6 months prior to Day 1.

12. Serious, non-healing wound, active ulcer, or untreated bone fracture.

13. Proteinuria

14. Known hypersensitivity to any component of bevacizumab

15. Pregnancy (positive pregnancy test) or lactation. Use of effective means of contraception (men and women) in subjects of child-bearing potential.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Genentech, Inc.

INDUSTRY

Sponsor Role: collaborator

Ajay Niranjan

OTHER

Sponsor Role: lead

Responsible Party

Ajay Niranjan

Professor

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Ajay Niranjan, MD

Role: PRINCIPAL_INVESTIGATOR

University of Pittsburgh Medical Center

Locations

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

Countries

United States

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

13-063

Identifier Type: -

Identifier Source: org_study_id