Lipoprotein and Apolipoproteins With Metabolic Liver Diseases

NCT ID: NCT03220971

Last Updated: 2018-04-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

440 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-09-20

Study Completion Date

2019-10-31

Brief Summary

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Theranostic translation applications against viral, metabolic liver diseases and hepatic oncogenesis: lipoprotein and apolipoproteins at a crossroad

Detailed Description

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An intimate link between microbial infections, metabolic changes and oncogenesis has been drawn attentions increasingly, indicating a crossroad leading to pathogenesis and disease progression. Globally the burden of hepatitis B and C virus infections is 450 and 185 millions, respectively and chronic hepatitis disease causes a high risk of liver cirrhosis, hepatocellular carcinoma and metabolic disorders

Conditions

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Disorders of Lipoprotein Metabolism and Other Lipidaemias

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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proposed cross-section study

1. 100 subjects with NAFLD/NASH and negative anti-HCV Ab
2. 50 subjects with HCC and negative anti-HCV Ab
3. 50 subjects with HCC and positive for genotype-1 HCV
4. 50 controls with all negative for NAFLD/NASH but positive for genotype-1 HCV
5. 50 controls with all negative for NAFL, NASH and HCV

lipoprotein and apolipoproteins

Intervention Type OTHER

To find out the role of lipoprotein and apolipoproteins (apos) in pathogenic hepatic diseases

proposed longitudinal study

1. 50 NAFLD/NASH patients and positive for genotype-1 HCV with SVR
2. 10 NAFLD/NASH patients and positive for genotype-1 HCV without SVR
3. 10 HCC patients and positive for genotype-1 HCV with SVR
4. 10 HCC patients and positive for genotype-1 HCV without SVR
5. 50 chronic hepatitis C but not NAFLD patients with SVR
6. 10 chronic hepatitis C but not NAFLD patients without SVR

lipoprotein and apolipoproteins

Intervention Type OTHER

To find out the role of lipoprotein and apolipoproteins (apos) in pathogenic hepatic diseases

Interventions

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lipoprotein and apolipoproteins

To find out the role of lipoprotein and apolipoproteins (apos) in pathogenic hepatic diseases

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. above 20 years
2. nonalcoholic fatty liver disease
3. Non-Alcoholic Steatohepatitis

Exclusion Criteria

1\. alcohonic hepatitis 2. Autoimmune liver disease 3. HIV postive

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Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chun-Hsiang Wang

OTHER

Sponsor Role lead

Responsible Party

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Chun-Hsiang Wang

Tainan Municipal Hospital

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Chun-Hsiang Wang

Tainan City, , Taiwan

Site Status

Countries

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Taiwan

Other Identifiers

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1060603

Identifier Type: -

Identifier Source: org_study_id

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