Inflammation and Cell Maturation in Preterm Delivery Placentas - in Vitro and in Vivo Effect of Progesterone
NCT ID: NCT03211338
Last Updated: 2022-06-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
115 participants
INTERVENTIONAL
2017-07-15
2022-06-06
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Preterm labor placentas and progesterone
IMC cells taken from preterm labor placentas after delivery will be cultured with progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Culture with progesterone
Progesterone, a steroid hormone will be cultured with placental IMC cells or peripheral blood CD14+ monocyte cells
Term labor placentas and progesterone
IMC cells taken from term labor placentas after delivery will be cultured with progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Culture with progesterone
Progesterone, a steroid hormone will be cultured with placental IMC cells or peripheral blood CD14+ monocyte cells
Preterm labor placentas without progesterone
IMC cells taken from preterm labor placentas after delivery will be cultured without progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Culture without progesterone
Culture of placental IMC cells or peripheral blood CD14+ monocyte cells without progesterone
Term labor placentas without progesterone
IMC cells taken from term labor placentas after delivery will be cultured without progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Culture without progesterone
Culture of placental IMC cells or peripheral blood CD14+ monocyte cells without progesterone
Term placentas from progesterone treated pregnancies
IMC cells taken from term labor placentas from women that were treated with progesterone during pregnancy will be analyzed for inflammation characteristics and maturation into DC cells.
Culture with growth factors
Culture of placental IMC cells with growth hormones only and analysis
Preterm placentas from progesterone treated pregnancies
IMC cells taken from preterm labor placentas from women that were treated with progesterone during pregnancy will be analyzed for inflammation characteristics and maturation into DC cells.
Culture with growth factors
Culture of placental IMC cells with growth hormones only and analysis
Term placentas not treated with progesterone in pregnancy
IMC cells taken from term placentas from women who were not treated with progesterone during pregnancy will be analyzed for inflammation characteristics and maturation into DC cells.
Culture with growth factors
Culture of placental IMC cells with growth hormones only and analysis
Preterm placentas not treated with progesterone in pregnancy
IMC cells taken from preterm placentas from women who were not treated with progesterone during pregnancy will be analyzed for inflammation characteristics and maturation into DC cells.
Culture with growth factors
Culture of placental IMC cells with growth hormones only and analysis
Term postpartum blood samples with progesterone
CD-14+ monocyte cells taken from women delivering at term will be cultured with progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Culture with progesterone
Progesterone, a steroid hormone will be cultured with placental IMC cells or peripheral blood CD14+ monocyte cells
Preterm postpartum blood samples with progesterone
CD-14+ monocyte cells taken from women delivering preterm will be cultured with progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Culture with progesterone
Progesterone, a steroid hormone will be cultured with placental IMC cells or peripheral blood CD14+ monocyte cells
Term postpartum blood samples without progesterone
CD-14+ monocyte cells taken from women delivering at term will be cultured without progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Culture without progesterone
Culture of placental IMC cells or peripheral blood CD14+ monocyte cells without progesterone
Preterm postpartum blood samples without progesterone
CD-14+ monocyte cells taken from women delivering preterm will be cultured without progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Culture without progesterone
Culture of placental IMC cells or peripheral blood CD14+ monocyte cells without progesterone
Interventions
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Culture with progesterone
Progesterone, a steroid hormone will be cultured with placental IMC cells or peripheral blood CD14+ monocyte cells
Culture without progesterone
Culture of placental IMC cells or peripheral blood CD14+ monocyte cells without progesterone
Culture with growth factors
Culture of placental IMC cells with growth hormones only and analysis
Eligibility Criteria
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Inclusion Criteria
* Singleton pregnancy
* Consent to participate
Exclusion Criteria
* Multiple gestation
* Maternal illness or fetal malformation known pre-delivery
18 Years
40 Years
FEMALE
Yes
Sponsors
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Hillel Yaffe Medical Center
OTHER_GOV
Responsible Party
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Principal Investigators
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Rinat Gabbay-Benziv, MD
Role: PRINCIPAL_INVESTIGATOR
Hillel Yaffe Medical Center
Locations
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Hillel Yaffe Medical Center
Hadera, , Israel
Countries
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Other Identifiers
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HYMC-0061-17
Identifier Type: -
Identifier Source: org_study_id
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