Safety and Efficacy of Heparin Dosing Score Protocol for Polymyxin-B Hemoperfusion

NCT ID: NCT03177330

Last Updated: 2017-06-06

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-05-15
• Study Completion Date: 2017-07-31

Brief Summary

Polymyxin B hemoperfusion (PMX-HP) is mainly used to remove endotoxins in septic shock patients with intra-abdominal infections. Because of the concerns of postoperative bleeding, physicians may hesitate to use anticoagulation in patients with septic shock within a few hours after an abdominal operation. We developed a heparin dosing score protocol for heparin dosage adjustment. The purpose of the study is to examine the safety and efficacy of the heparin dosing score protocol.

Conditions

Septic Shock; Polymyxin B Hemoperfusion

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: RETROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• intra-abdominal septic shock patients or documented Gram-negative bacterial septic shock patients who received polymyxin-B hemoperfusion in National Taiwan University Hospital during October 2013-December 2016

Exclusion Criteria

• pregnant woman
• patients with do-not-resuscitate declaration
• uncontrolled bleeding within 24hr

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Taiwan University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Department of Anesthesiology, NTUH, Taipei, Taiwan

Taipei, , Taiwan

Site Status: RECRUITING

Countries

Taiwan

Central Contacts

Chen-Tse Lee, MD

Role: CONTACT

lctbrian314@gmail.com

+886972653169

Facility Contacts

Chen-Tse Lee, M.D.

Role: primary

lctbrian314@gmail.com

+886-2-23123456 ext. 62158

Other Identifiers

201704033RIND

Identifier Type: -

Identifier Source: org_study_id