Prognostic Value of P30 After Cardiac Arrest

NCT ID: NCT03175965

Last Updated: 2019-05-14

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 88 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-07-01
• Study Completion Date: 2018-11-30

Brief Summary

This study aims to examine whether P30 wave of somatosensory evoked potentials (SEP) is related with outcome after cardiac arrest. The study design is a prospective, multicenter-observational study. Patients survived after out-of-hospital cardiac arrest undergoing hypothermic-targeted temperature management will participate in the study. Relationship of P30 wave of SEP with the neurologic outcome on hospital discharge will be evaluated.

Detailed Description

The absence of N20 of the somatosensory evoked potentials (SEP) is recommended as a valuable predictor of poor neurologic outcome in post-cardiac arrest patients. However, interpretation of N20 is affected by the background noise levels. Reliable analysis of N20 is limited with high noise levels and artifacts. Moreover, presence of N20 does not guarantee good neurologic outcome. P30 is a positive deflection of N20 occurring on 25-35 msec. According to our pilot study, N20 without following P30 is related with poor outcome, while N20 followed by P30 is highly related with good outcome. P30 is evident even when the N20 is ambiguous in patients with good outcome. We hypothesized that the negative-positive deflection of N20-P30 components is more valuable predictor than the N20 alone. In this observational study, we will identify whether presence of P30 checked on 24 and 72 hours after cardiac arrest predicts neurologic outcome more accurately than the presence of N20 alone.

Conditions

Out-Of-Hospital Cardiac Arrest

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

Somatosensory evoked potential

Somatosensory evoked potential on 24, 72 hours after cardiac arrest.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Comatose survivors after out-of-hospital cardiac arrest

Exclusion Criteria

• Not treated by hypothermic-targeted temperature management

• Minimum Eligible Age: 19 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The Catholic University of Korea

OTHER

Sponsor Role: collaborator

Uijeongbu St. Mary Hospital

OTHER

Sponsor Role: lead

Responsible Party

Joo Suk Oh, MD. PhD.

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Joo Suk Oh, MD

Role: STUDY_CHAIR

Uijeongbu St. Mary's Hospital

Locations

Bucheon St. Mary's Hospital

Bucheon-si, Gyeonggi-do, South Korea

Uijeongbu St. Mary's Hospital

Uijeongbu-si, Gyeonggi-do, South Korea

Seoul St. Mary's Hospital

Seoul, , South Korea

Yeouido St. Mary's Hospital

Seoul, , South Korea

Countries

South Korea

Other Identifiers

XC17OEDI0009

Identifier Type: -

Identifier Source: org_study_id