Bone Mass Accrual in Children With Autism Spectrum Disorder

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

49 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-11

Study Completion Date

2016-01-31

Brief Summary

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This is a observational study to investigate the degree to which bone mineral density is impaired in boys with autism compared with typically developing controls.

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Detailed Description

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Studies have shown that bone cortical thickness is decreased in children with autism and other developmental disabilities. However it is not known whether bone mineral density (BMD) of these children is lower; neither is it known whether there is any correlation between BMD and the child's diet. The overall goal of this study is to improve the long term health of children and adolescents with autism spectrum disorder; more specifically the investigators aim to develop a pilot study to investigate the degree to which BMD is impaired in boys with autism and to explore specific additional risk factors. In addition, the aim is to investigate the degree to which BMD is impaired in boys with Autism Spectrum Disorder (ASD) and to explore specific contributing risk factors including nutritional analysis.

Conditions

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Autism Spectrum Disorder Bone Diseases, Developmental

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Typically developing controls

Boys between ages 7 and 14 years old at study onset without medications or diseases impairing bone development

No interventions assigned to this group

Autism spectrum disorder

Boys between ages 7 and 14 years old at study onset without medications or diseases impairing bone development

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Boys 8-17 years chronological age
* BMI between the 3rd and 97th percentiles
* Meets DSM-IV criteria for Autism Spectrum Disorder (ASD group)
* Scores \<15 on the Social Communication Questionnaire (control group)

Exclusion Criteria

* Use of medications directly affecting bone metabolism including estrogen/ progesterone preparations and glucocorticoids except local application of glucocorticoid
* Use of anticonvulsants which affect bone density including diphenylhydantoin, phenobarbital, topiramate carbamazepine and valproic acid and also use of lithium
* Children with diseases known to affect bone mineral density including Crohn's disease, celiac, thyroid and renal
* Children who will not tolerate lying still for 30 seconds

Minimum Eligible Age

8 Years

Maximum Eligible Age

17 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes