Differential Diagnostics of Etiology of Acute Infections

NCT ID: NCT03161951

Last Updated: 2019-01-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

169 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-03

Study Completion Date

2018-12-29

Brief Summary

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Method for diagnostics of the origin of infections (bacterial vs viral) based on the identification of activation markers of blood neutrophils and monocytes will be developed.

Detailed Description

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During the study, method for diagnostics of the origin of infections (bacterial vs viral) based on the identification of activation markers of blood neutrophils and monocytes will be developed.This method will allow to make a diagnosis within an hour after blood sampling.

The expression of the following markers of activation will be studied using flow cytometry: CD11b, CD11c, CD13, CD16, CD32, CD35, CD38, CD62L, CD64, CD66b, CD88, CD284, HLA-ABC and HLA-DR.

Conditions

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Intestinal Infectious Diseases Neuroinfections

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Neuroinfections

Patients with acute neuroinfections of bacterial and viral ethology.

No interventions assigned to this group

Intestinal Infectious Diseases

Patients with acute intestinal infectious diseases of bacterial and viral ethology.

No interventions assigned to this group

Control group

Control group of healthy persons

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* neuroinfections or acute intestinal infections;
* the possibility of blood sampling within a period of up to 24 hours from the moment of admission to hospital;
* less than 72 hours passed after the onset of the disease and until blood was collected;

Exclusion Criteria

* refuse of patient to participate in the trial;
* more than 24 hours passed after the patient entered the hospital;
* the disease began more than 72 hours ago;
* concomitant severe acute and chronic diseases;
* malignant neoplasms, treatment at a time of less than 1 year, autoimmune diseases in the phase of exacerbation;
* pregnancy/lactation;
* HIV, Hepatites B/C;
* active tuberculosis;
* alcohol use disorder/drug addiction.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Republican Research and Practical Center for Epidemiology and Microbiology

OTHER

Sponsor Role lead

Responsible Party

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Andrei Y. Hancharou

Head of the Laboratory for Immunology and Cellular Biotechnology,

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Andrei Y Hancharou, Dr

Role: STUDY_DIRECTOR

Head of the Laboratory for Immunology and Cellular Biotechnology, The Republican Research and Practical Center for Epidemiology and Microbiology

Other Identifiers

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RRPCEM_NMAT

Identifier Type: -

Identifier Source: org_study_id

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