Investigating Accelerated Learning in Tinnitus Participants Implanted With Vagus Nerve Stimulation
NCT ID: NCT03143842
Last Updated: 2022-01-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
NA
INTERVENTIONAL
2017-04-27
2022-01-25
Brief Summary
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Detailed Description
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Vagus Nerve Stimulation (VNS) has been delivered to patient populations (e.g. depression, epilepsy, …) for more than 25 years and there has been some indications that this technique has effects on cognition, more specifically memory. Studies have investigated VNS as a way to improve memory performance and it has been shown in some studies to enhance memory in rats and humans. It has also demonstrated to produce changes in the electrophysiological and metabolic profile of forebrain and brainstem structures involved in learning and memory.
To investigate whether VNS can accelerate learning and improve associative memory when learning word pairs, we will investigate the performance of VNS implanted participants on a Verbal Paired-Associate memory task and compare their performance on the words that were learned while paired with VNS in contrast to their performance on the words that were learned while unpaired with VNS and in contrast to their performance on the words that were learned without VNS (i.e. 3 types/groups of words: paired with VNS, unpaired with VNS and without VNS) during the first visit and 1 day,1 week and 1 month after their first visit.
Conditions
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Study Design
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NA
SINGLE_GROUP
To investigate whether VNS can accelerate learning and improve associative memory when learning word pairs, we will investigate the performance of VNS implanted participants on a Verbal Paired-Associate memory task and compare their performance on the words that were learned while paired with VNS in contrast to their performance on the words that were learned while unpaired with VNS and in contrast to their performance on the words that were learned without VNS (i.e. 3 types/groups of words: paired with VNS, unpaired with VNS and without VNS) during the first visit and 1 day,1 week and 1 month after their first visit.
BASIC_SCIENCE
NONE
Study Groups
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Vagus Nerve Stimulation
VNS paired with word pairs, VNS unpaired with word pairs, no VNS
Vagus Nerve Stimulation
Delivering electrical pulses to the Vagus Nerve
Interventions
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Vagus Nerve Stimulation
Delivering electrical pulses to the Vagus Nerve
Eligibility Criteria
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Inclusion Criteria
* Native English speaker
Exclusion Criteria
18 Years
70 Years
ALL
No
Sponsors
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Defense Advanced Research Projects Agency
FED
The University of Texas at Dallas
OTHER
Responsible Party
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Sven Vanneste
Associate professor
Principal Investigators
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Sven Vanneste, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
The University of Texas at Dallas
Locations
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The University of Texas of Dallas
Richardson, Texas, United States
Countries
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Other Identifiers
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17-47
Identifier Type: -
Identifier Source: org_study_id
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