Pancreatic Cancer Models Developed From EUS Guided Biopsy Tissue

NCT ID: NCT03140592

Last Updated: 2021-03-19

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 300 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-01-14
• Study Completion Date: 2023-01-31

Brief Summary

Pancreatic cancer is a very aggressive cancer. Over the past 40 years there has not been much progress made in reducing deaths from this cancer. Recently, new models of pancreatic cancers have been generated from mouse and human tissues. These models have used larger pieces of tissues taken from surgical removal of pancreatic cancers.

The purpose of this study is to determine whether these new pancreatic cancer models can be generated from the small biopsies we take to make the diagnosis of the pancreatic mass.

Detailed Description

The Endoscopic Ultrasound guided pancreatic biopsy tissue collected for only research purposes will be used to generate organoids in a in-vivo and in-vitro setting.

The development of these methods may help scientists identify new treatments for pancreatic cancer and to potentially develop more personalized approaches to treating pancreatic cancer.

Conditions

Pancreatic Cancer; Pancreatic Adenocarcinoma; Pancreatic Cyst

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

Biopsy

Two extra EUS guided pancreatic biopsies collected for only research purposes.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. Patients who are scheduled for an EUS-FNB of pancreatic mass(es) suspicious for pancreatic ductal adenocarcinoma performed by a member of the Stony Brook Interventional Endoscopy Section of the Division of Gastroenterology and Hepatology

1. Age ≥ 18 years

2. Literate and able/willing to provide informed consent for participation in research.

Exclusion Criteria

1. Age < 18 years

2. Not literate or unable/unwilling to provide informed consent for EUS-FNB research biopsies

3. Pregnancy as determined by serum or urine HCG test performed as standard of clinical care for all women of childbearing age and documented on subjects' electronic medical record

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Stony Brook University

OTHER

Sponsor Role: lead

Responsible Party

Jonathan Buscaglia

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jonathan Buscaglia, MD

Role: PRINCIPAL_INVESTIGATOR

Stony Brook University

Locations

Stony Brook University

Stony Brook, New York, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Jonathan Buscaglia, MD

Role: CONTACT

jonathan.buscaglia@stonybrookmedicine.edu

6314447225

Joseph LaComb, BS

Role: CONTACT

joseph.lacomb@stonybrookmedicine.edu

6314449532

Facility Contacts

Jonathan Buscaglia, MD

Role: primary

jonathan.buscaglia@stonybrookmedicine.edu

References

Lacomb JF, Plenker D, Tiriac H, Bucobo JC, D'souza LS, Khokhar AS, Patel H, Channer B, Joseph D, Wu M, Tuveson DA, Li E, Buscaglia JM. Single-Pass vs 2-Pass Endoscopic Ultrasound-Guided Fine-Needle Biopsy Sample Collection for Creation of Pancreatic Adenocarcinoma Organoids. Clin Gastroenterol Hepatol. 2021 Apr;19(4):845-847. doi: 10.1016/j.cgh.2020.02.045. Epub 2020 Feb 29.

Reference Type: DERIVED

PMID: 32119924 (View on PubMed)

Tiriac H, Bucobo JC, Tzimas D, Grewel S, Lacomb JF, Rowehl LM, Nagula S, Wu M, Kim J, Sasson A, Vignesh S, Martello L, Munoz-Sagastibelza M, Somma J, Tuveson DA, Li E, Buscaglia JM. Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment. Gastrointest Endosc. 2018 Jun;87(6):1474-1480. doi: 10.1016/j.gie.2017.12.032. Epub 2018 Jan 9.

Reference Type: DERIVED

PMID: 29325707 (View on PubMed)

Other Identifiers

IRBNet # 618834

Identifier Type: -

Identifier Source: org_study_id