B2 Adrenergic Receptor Gene Polymorphism in Bronchial Asthma
NCT ID: NCT03118869
Last Updated: 2017-08-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
75 participants
OBSERVATIONAL
2017-04-01
2017-10-30
Brief Summary
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The b2AR gene is located on chromosome 5q31-q32, a region that is genetically linked to asthma and related phenotypes. There are three best known polymorphisms in the coding region of the b2AR gene that can modulate the function of the receptor.
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Detailed Description
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The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection. The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection, Enhanced mucociliary clearance.
The b2AR gene is located on chromosome 5q31-q32, a region that is genetically linked to asthma and related phenotypes. There are three best known polymorphisms in the coding region of the b2AR gene that can modulate the function of the receptor.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Allergic asthma
Exclusion Criteria
* chronic cardiac, hepatic and renal diseases
* pregnancy and lactation
* malignancy
18 Years
65 Years
ALL
Yes
Sponsors
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Assiut University
OTHER
Responsible Party
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Aliae AR Mohamed Hussein
Prof. Dr. Aliae AR Mohamed-Hussein, Professor of Pulmonology
Principal Investigators
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Aliae Mohamed-Hussein
Role: PRINCIPAL_INVESTIGATOR
Professor of Pulmonology- Faculty of Medicine-Assiut University
Locations
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AssiutU
Asyut, , Egypt
Countries
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References
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Mohamed-Hussein AAR, Sayed SS, Eldien HMS, Assar AM, Yehia FE. Beta 2 Adrenergic Receptor Genetic Polymorphisms in Bronchial Asthma: Relationship to Disease Risk, Severity, and Treatment Response. Lung. 2018 Dec;196(6):673-680. doi: 10.1007/s00408-018-0153-3. Epub 2018 Sep 3.
Other Identifiers
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AssiutU3
Identifier Type: -
Identifier Source: org_study_id
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